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Volumn 52, Issue 3, 2000, Pages 223-228

Brain interleukin-1β and tumor necrosis factor-α are involved in lipopolysaccharide-induced delayed rectal allodynia in awake rats

Author keywords

Allodynia; Central nervous system; Interleukin 1 ; Lipopolysaccharide; Rats; Rectal distension; Tumor necrosis factor

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; LIPOPOLYSACCHARIDE; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; CYSTEINE PROTEINASE INHIBITOR; INTERLEUKIN 1; INTERLEUKIN-1BETA-CONVERTING ENZYME INHIBITOR; RECOMBINANT PROTEIN; SERINE PROTEINASE INHIBITOR; VIRUS PROTEIN;

EID: 0033625450     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(00)00269-0     Document Type: Article
Times cited : (28)

References (46)
  • 1
    • 0026760984 scopus 로고
    • Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor alpha
    • Aloisi F., Care A., Borsellino G., Gallo P., Rosa S., Bassani A., Cabibbo A., Testa U., Levi G., Peschle C. Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor alpha. J. Immunol. 149:1992;2358-2366.
    • (1992) J. Immunol. , vol.149 , pp. 2358-2366
    • Aloisi, F.1    Care, A.2    Borsellino, G.3    Gallo, P.4    Rosa, S.5    Bassani, A.6    Cabibbo, A.7    Testa, U.8    Levi, G.9    Peschle, C.10
  • 2
    • 0022494761 scopus 로고
    • Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages
    • Bachwich P.R., Chensue S.W., Larrick J.W., Kunkel S.L. Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages. Biochem. Biophys. Res. Commun. 136:1986;94-101.
    • (1986) Biochem. Biophys. Res. Commun. , vol.136 , pp. 94-101
    • Bachwich, P.R.1    Chensue, S.W.2    Larrick, J.W.3    Kunkel, S.L.4
  • 3
    • 85025404652 scopus 로고
    • Tolerance to bacterial pyrogens. Factors influencing its development
    • Beeson P.B. Tolerance to bacterial pyrogens. Factors influencing its development. J. Exp. Med. 86:1947;29-38.
    • (1947) J. Exp. Med. , vol.86 , pp. 29-38
    • Beeson, P.B.1
  • 4
    • 0026733961 scopus 로고
    • Central effects of tumor necrosis factor alpha and interleukin-1 alpha on nociceptive thresholds and spontaneous locomotor activity
    • Bianchi M., Sacerdote P., Ricciardi-Castagnoli P., Mantegazza P., Panerai A.E. Central effects of tumor necrosis factor alpha and interleukin-1 alpha on nociceptive thresholds and spontaneous locomotor activity. Neurosci. Lett. 148:1992;76-80.
    • (1992) Neurosci. Lett. , vol.148 , pp. 76-80
    • Bianchi, M.1    Sacerdote, P.2    Ricciardi-Castagnoli, P.3    Mantegazza, P.4    Panerai, A.E.5
  • 5
    • 0027945999 scopus 로고
    • Regional induction of tumor necrosis factor α expression in the mouse brain after systemic lipopolysaccharide administration
    • Breder C.D., Hazuka C., Ghayur T., Klug C., Huginin M., Yasuda K., Teng M., Saper C.B. Regional induction of tumor necrosis factor α expression in the mouse brain after systemic lipopolysaccharide administration. Proc. Natl. Acad. Sci. USA. 91:1994;11393-11397.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11393-11397
    • Breder, C.D.1    Hazuka, C.2    Ghayur, T.3    Klug, C.4    Huginin, M.5    Yasuda, K.6    Teng, M.7    Saper, C.B.8
  • 6
    • 0028821428 scopus 로고
    • Peripheral lipopolysaccharide stimulation induces interleukin-1β messenger RNA in rat brain microglial cells
    • Buttini M., Boddeke H.W.G.M. Peripheral lipopolysaccharide stimulation induces interleukin-1β messenger RNA in rat brain microglial cells. Neuroscience. 65:1995;523-530.
    • (1995) Neuroscience , vol.65 , pp. 523-530
    • Buttini, M.1    Boddeke, H.W.G.M.2
  • 7
    • 0030780744 scopus 로고    scopus 로고
    • Lipopolysaccharide induces expression of tumor necrosis factor alpha in rat brain: Inhibition by methylprednisolone and by rolipram
    • Buttini M., Mir A., Appel K., Wiederhold K.H., Limonta S., Gebicke-Haerter P.J., Boddeke H.W.G.M. Lipopolysaccharide induces expression of tumor necrosis factor alpha in rat brain Inhibition by methylprednisolone and by rolipram . Br. J. Pharmacol. 122:1997;1483-1489.
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 1483-1489
    • Buttini, M.1    Mir, A.2    Appel, K.3    Wiederhold, K.H.4    Limonta, S.5    Gebicke-Haerter, P.J.6    Boddeke, H.W.G.M.7
  • 8
    • 0019944834 scopus 로고
    • Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by medial preoptic and septal stimulation in the cat
    • Carstens E., MacKinnon J.D., Guinan M.J. Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by medial preoptic and septal stimulation in the cat. J. Neurophysiol. 48:1982;981-989.
    • (1982) J. Neurophysiol. , vol.48 , pp. 981-989
    • Carstens, E.1    MacKinnon, J.D.2    Guinan, M.J.3
  • 9
    • 0023942592 scopus 로고
    • Occurence of interleukin-1 in cerebrospinal fluid of the conscious cat
    • Coceani F., Lees J., Dinarello C.A. Occurence of interleukin-1 in cerebrospinal fluid of the conscious cat. Brain Res. 446:1988;245-250.
    • (1988) Brain Res. , vol.446 , pp. 245-250
    • Coceani, F.1    Lees, J.2    Dinarello, C.A.3
  • 10
    • 0001981919 scopus 로고    scopus 로고
    • Lipopolysaccharide induces a delayed rectal allodynia via mast cell degranulation in rats
    • Coelho A.M., Fioramonti J., Buéno L. Lipopolysaccharide induces a delayed rectal allodynia via mast cell degranulation in rats. Neurogastroenterol. Mot. 10:1998;65.
    • (1998) Neurogastroenterol. Mot. , vol.10 , pp. 65
    • Coelho, A.M.1    Fioramonti, J.2    Buéno, L.3
  • 11
    • 0026787367 scopus 로고
    • The pivotal role of tumor necrosis factor α in the development of inflammatory hyperalgesia
    • Cunha F.Q., Poole S., Lorenzetti B.B., Ferreira S.H. The pivotal role of tumor necrosis factor α in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 107:1992;660-664.
    • (1992) Br. J. Pharmacol. , vol.107 , pp. 660-664
    • Cunha, F.Q.1    Poole, S.2    Lorenzetti, B.B.3    Ferreira, S.H.4
  • 12
    • 0025362271 scopus 로고
    • Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6
    • De Simoni M.G., Sironi M., De Luigi A., Manfridi A., Mantovani A., Ghezzi P. Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6. J. Exp. Med. 171:1990;1773-1778.
    • (1990) J. Exp. Med. , vol.171 , pp. 1773-1778
    • De Simoni, M.G.1    Sironi, M.2    De Luigi, A.3    Manfridi, A.4    Mantovani, A.5    Ghezzi, P.6
  • 14
    • 0030834382 scopus 로고    scopus 로고
    • Central lipopolysaccharide elevates plasma IL-6 concentration by an adrenoreceptor-mediated mechanism
    • Finck B.N., Dantzer R., Kelley K.W., Woods J.A., Johnson R.W. Central lipopolysaccharide elevates plasma IL-6 concentration by an adrenoreceptor-mediated mechanism. Am. J. Physiol. 272:1997;R1880-R1887.
    • (1997) Am. J. Physiol. , vol.272 , pp. 1880-R1887
    • Finck, B.N.1    Dantzer, R.2    Kelley, K.W.3    Woods, J.A.4    Johnson, R.W.5
  • 15
    • 0027214546 scopus 로고
    • Induction of tumor necrosis factor α mRNA in the brain after peripheral endotoxin treatment: Comparison with interleukin-1 family and interleukin-6
    • Gatti S., Bartfai T. Induction of tumor necrosis factor α mRNA in the brain after peripheral endotoxin treatment Comparison with interleukin-1 family and interleukin-6 . Brain Res. 624:1993;291-294.
    • (1993) Brain Res. , vol.624 , pp. 291-294
    • Gatti, S.1    Bartfai, T.2
  • 16
    • 0028359385 scopus 로고
    • Direct spinal pathways to the limbic system for nociceptive information
    • Giesler C.J., Katter J., Dado R. Direct spinal pathways to the limbic system for nociceptive information. Trends Neurosci. 17:1994;244-250.
    • (1994) Trends Neurosci. , vol.17 , pp. 244-250
    • Giesler, C.J.1    Katter, J.2    Dado, R.3
  • 17
    • 0027058881 scopus 로고
    • Increased circulating interleukin-1 and interleukin-6 after intracerebroventricular injection of lipopolysaccharide
    • Gottschall P.E., Komaki G., Arimura A. Increased circulating interleukin-1 and interleukin-6 after intracerebroventricular injection of lipopolysaccharide. Neuroendocrinology. 56:1992;935-938.
    • (1992) Neuroendocrinology , vol.56 , pp. 935-938
    • Gottschall, P.E.1    Komaki, G.2    Arimura, A.3
  • 18
    • 0026530042 scopus 로고
    • Tolerance to endotoxin prevents mortality in infected thermal injury: Association with attenuated cytokine response
    • He W., Fong Y., Marano M.A., Gershenwald J.E., Yurt R.W., Moldawer L.L., Lowry S.F. Tolerance to endotoxin prevents mortality in infected thermal injury association with attenuated cytokine response . J. Infect. Dis. 165:1992;859-864.
    • (1992) J. Infect. Dis. , vol.165 , pp. 859-864
    • He, W.1    Fong, Y.2    Marano, M.A.3    Gershenwald, J.E.4    Yurt, R.W.5    Moldawer, L.L.6    Lowry, S.F.7
  • 19
    • 0030743541 scopus 로고    scopus 로고
    • Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats
    • Hosoi M., Oka T., Hori T. Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats. Pain. 71:1997;303-311.
    • (1997) Pain , vol.71 , pp. 303-311
    • Hosoi, M.1    Oka, T.2    Hori, T.3
  • 20
    • 0027169378 scopus 로고
    • Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1
    • Kakucska I., Qi Y., Clark B.D., Lechan R.M. Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1. Endocrinology. 133:1993;815-821.
    • (1993) Endocrinology , vol.133 , pp. 815-821
    • Kakucska, I.1    Qi, Y.2    Clark, B.D.3    Lechan, R.M.4
  • 23
    • 0027515268 scopus 로고
    • Role of hypothalamic interleukin-6 and tumor necrosis factor-α In LPS fever in rat
    • Klir J.J., Roth J., Szelényi Z., McClellan J.L., Kluger M.J. Role of hypothalamic interleukin-6 and tumor necrosis factor-α in LPS fever in rat. Am. J. Physiol. 265:1993;R512-R517.
    • (1993) Am. J. Physiol. , vol.265 , pp. 512-R517
    • Klir, J.J.1    Roth, J.2    Szelényi, Z.3    McClellan, J.L.4    Kluger, M.J.5
  • 24
    • 0028073528 scopus 로고
    • Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and in the pituitary of mice
    • Layé S., Parnet P., Goujon E., Dantzer R. Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and in the pituitary of mice. Mol. Brain Res. 27:1994;157-162.
    • (1994) Mol. Brain Res. , vol.27 , pp. 157-162
    • Layé, S.1    Parnet, P.2    Goujon, E.3    Dantzer, R.4
  • 25
    • 0001139213 scopus 로고
    • Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus
    • Lieberman A.P., Pitha P.M., Shin H.S., Shin M.L. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc. Natl. Acad. Sci. USA. 86:1989;6348-6352.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 6348-6352
    • Lieberman, A.P.1    Pitha, P.M.2    Shin, H.S.3    Shin, M.L.4
  • 26
    • 0028968980 scopus 로고
    • Effect of bacterial endotoxin and interleukin-1β on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: An in vivo microdialysis study
    • Linthorst A.C., Flachskamm C., Muller-Preuss P., Holsboer F., Reul J.M. Effect of bacterial endotoxin and interleukin-1β on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels An in vivo microdialysis study . J. Neurosci. 15:1995;2920-2934.
    • (1995) J. Neurosci. , vol.15 , pp. 2920-2934
    • Linthorst, A.C.1    Flachskamm, C.2    Muller-Preuss, P.3    Holsboer, F.4    Reul, J.M.5
  • 27
    • 0030064395 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat
    • Luheshi G., Miller A.J., Brouwer S., Dascombe M.J., Rothwell N.J., Hopkins S.J. Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat. Am. J. Physiol. 270:1996;E91-E95.
    • (1996) Am. J. Physiol. , vol.270 , pp. 91-E95
    • Luheshi, G.1    Miller, A.J.2    Brouwer, S.3    Dascombe, M.J.4    Rothwell, N.J.5    Hopkins, S.J.6
  • 28
    • 0023270784 scopus 로고
    • Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- And A-delta mechanonociceptors in the hairy skin of rat hindlimbs
    • Martin H.A., Basbaum A.I., Kwiat G.C., Goetzl E.J., Levine J.D. Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbs. Neuroscience. 22:1987;651-659.
    • (1987) Neuroscience , vol.22 , pp. 651-659
    • Martin, H.A.1    Basbaum, A.I.2    Kwiat, G.C.3    Goetzl, E.J.4    Levine, J.D.5
  • 29
    • 0023138620 scopus 로고
    • Hypothalamic control of nocireceptive and other neurons in the marginal mayer of the dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat
    • Mokha S.S., Goldsmith G.E., Hellon R.F., Puri R. Hypothalamic control of nocireceptive and other neurons in the marginal mayer of the dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat. Exp. Brain Res. 65:1987;427-736.
    • (1987) Exp. Brain Res. , vol.65 , pp. 427-736
    • Mokha, S.S.1    Goldsmith, G.E.2    Hellon, R.F.3    Puri, R.4
  • 30
    • 0028339447 scopus 로고
    • Experimental colitis alters visceromotor response to colorectal distension in awake rats
    • Morteau O., Hachet T., Caussette M., Buéno L. Experimental colitis alters visceromotor response to colorectal distension in awake rats. Dig. Dis. Sci. 39:1994;1239-1248.
    • (1994) Dig. Dis. Sci. , vol.39 , pp. 1239-1248
    • Morteau, O.1    Hachet, T.2    Caussette, M.3    Buéno, L.4
  • 31
    • 0026755375 scopus 로고
    • Interleukin-1 beta and interleukin-6 specifically increase the release of prostaglandin E2 from rat hypothalamic explants in vitro
    • Navarra P., Pozzoli G., Brunetti L., Ragazzoni E., Besser M., Grossman A. Interleukin-1 beta and interleukin-6 specifically increase the release of prostaglandin E2 from rat hypothalamic explants in vitro. Neuroendocrinology. 56:1992;61-68.
    • (1992) Neuroendocrinology , vol.56 , pp. 61-68
    • Navarra, P.1    Pozzoli, G.2    Brunetti, L.3    Ragazzoni, E.4    Besser, M.5    Grossman, A.6
  • 32
    • 0028169560 scopus 로고
    • Intracerebroventricular injection of interleukin-1β enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats
    • Oka T., Aou S., Hori T. Intracerebroventricular injection of interleukin-1β enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats. Brain Res. 656:1994;236-244.
    • (1994) Brain Res. , vol.656 , pp. 236-244
    • Oka, T.1    Aou, S.2    Hori, T.3
  • 33
    • 0027304730 scopus 로고
    • Intracerebroventricular injection of interleukin-1β induces hyperalgesia in rats
    • Oka T., Aou S., Hori T. Intracerebroventricular injection of interleukin-1β induces hyperalgesia in rats. Brain Res. 624:1993;61-68.
    • (1993) Brain Res. , vol.624 , pp. 61-68
    • Oka, T.1    Aou, S.2    Hori, T.3
  • 34
    • 0028143593 scopus 로고
    • Intracerebroventricular injection of prostaglandin E2 induces thermal hyperalgesia in rats: The possible involvement of EP3 receptors
    • Oka T., Aou S., Hori T. Intracerebroventricular injection of prostaglandin E2 induces thermal hyperalgesia in rats The possible involvement of EP3 receptors . Brain Res. 663:1994;287-292.
    • (1994) Brain Res. , vol.663 , pp. 287-292
    • Oka, T.1    Aou, S.2    Hori, T.3
  • 35
    • 0028973577 scopus 로고
    • The opposing effects of interleukin-1β microinjected into the preoptic hypothalamus and the ventromedial hypothalamus on nociceptive behavior in rats
    • Oka T., Oka K., Hosoi M., Aou S., Hori T. The opposing effects of interleukin-1β microinjected into the preoptic hypothalamus and the ventromedial hypothalamus on nociceptive behavior in rats. Brain Res. 700:1995;271-278.
    • (1995) Brain Res. , vol.700 , pp. 271-278
    • Oka, T.1    Oka, K.2    Hosoi, M.3    Aou, S.4    Hori, T.5
  • 36
    • 0029845521 scopus 로고    scopus 로고
    • Intracerebroventricular injection of tumor necrosis factor-alpha induces thermal hyperalgesia in rats
    • Oka T., Wakugawa Y., Hosoi M., Oka K., Hori T. Intracerebroventricular injection of tumor necrosis factor-alpha induces thermal hyperalgesia in rats. Neuroimmunomodulation. 3:1996;135-140.
    • (1996) Neuroimmunomodulation , vol.3 , pp. 135-140
    • Oka, T.1    Wakugawa, Y.2    Hosoi, M.3    Oka, K.4    Hori, T.5
  • 37
    • 0028314343 scopus 로고
    • Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide
    • Quan N., Sundar S.K., Weiss J.M. Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide. J. Neuroimmunol. 49:1994;125-134.
    • (1994) J. Neuroimmunol. , vol.49 , pp. 125-134
    • Quan, N.1    Sundar, S.K.2    Weiss, J.M.3
  • 38
    • 0028317949 scopus 로고
    • Pharmacology of interleukin-1 actions in the brain
    • J.T. August, N.W. Anders, & F. Murad. New York: Academic Press
    • Rothwell N.J., Luheshi G. Pharmacology of interleukin-1 actions in the brain. August J.T., Anders N.W., Murad F. Advances in pharmacology. 1994;1-20 Academic Press, New York.
    • (1994) Advances in Pharmacology , pp. 1-20
    • Rothwell, N.J.1    Luheshi, G.2
  • 39
    • 0016737740 scopus 로고
    • Electrical spiking activity and propulsion in small intestine in fed and fasted rats
    • Ruckebusch Y., Fioramonti J. Electrical spiking activity and propulsion in small intestine in fed and fasted rats. Gastroenterology. 68:1975;1500-1508.
    • (1975) Gastroenterology , vol.68 , pp. 1500-1508
    • Ruckebusch, Y.1    Fioramonti, J.2
  • 40
    • 0027970546 scopus 로고
    • Gene expression and function of interleukin-1, interleukin-6 and tumor necrosis factor in the brain
    • Schöbitz B., De Kloet R., Holsboer F. Gene expression and function of interleukin-1, interleukin-6 and tumor necrosis factor in the brain. Prog. Neurobiol. 44:1994;397-432.
    • (1994) Prog. Neurobiol. , vol.44 , pp. 397-432
    • Schöbitz, B.1    De Kloet, R.2    Holsboer, F.3
  • 41
    • 0026726031 scopus 로고
    • Appearance of interleukin-1 in macrophage and in ramified microglia in the brain of endotoxin-treated rats: A pathway for the induction of non-specific symptoms of sickness?
    • van Dam A.M., Brouns M., Louisse S., Berkenbosch F. Appearance of interleukin-1 in macrophage and in ramified microglia in the brain of endotoxin-treated rats A pathway for the induction of non-specific symptoms of sickness? Brain Res. 588:1992;291-296.
    • (1992) Brain Res. , vol.588 , pp. 291-296
    • Van Dam, A.M.1    Brouns, M.2    Louisse, S.3    Berkenbosch, F.4
  • 42
    • 0029162558 scopus 로고
    • Cytokine-to-brain communication: A review and analysis of alternative mechanisms
    • Watkins L.R., Maier S.F., Goehler L.E. Cytokine-to-brain communication A review and analysis of alternative mechanisms . Life Sci. 57:1995;1011-1026.
    • (1995) Life Sci. , vol.57 , pp. 1011-1026
    • Watkins, L.R.1    Maier, S.F.2    Goehler, L.E.3
  • 45
    • 0029917664 scopus 로고    scopus 로고
    • Induction of interleukin-1β mRNA in the hypothalamus following subcutaneous injections of formalin into the rat hind paw
    • Yabuuchi K., Maruta E., Minami M., Satoh M. Induction of interleukin-1β mRNA in the hypothalamus following subcutaneous injections of formalin into the rat hind paw. Neurosci. Lett. 207:1996;109-112.
    • (1996) Neurosci. Lett. , vol.207 , pp. 109-112
    • Yabuuchi, K.1    Maruta, E.2    Minami, M.3    Satoh, M.4
  • 46
    • 0029874726 scopus 로고    scopus 로고
    • Biphasic effects of intracerebroventricular interleukin-1β on mechanical nociception in the rat
    • Yabuuchi K., Nishiyori A., Minami M., Satoh M. Biphasic effects of intracerebroventricular interleukin-1β on mechanical nociception in the rat. Eur. J. Pharmacol. 300:1996;59-65.
    • (1996) Eur. J. Pharmacol. , vol.300 , pp. 59-65
    • Yabuuchi, K.1    Nishiyori, A.2    Minami, M.3    Satoh, M.4


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