Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 2037-2038

  Mitsuya, Morihiro ^a   Kawakami, Kumiko ^a   Ogino, Yoshio ^a   Miura, Keiko ^a   Mase, Toshiaki ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; CARBOXYLIC ACID; CYCLOPENTENONE; CYCLOPENTYLDIOXOLANE; J 104129; MUSCARINIC M3 RECEPTOR ANTAGONIST; SODIUM HYDROXIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG HYDROLYSIS; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

ALKENES; CRYSTALLOGRAPHY, X-RAY; MOLECULAR STRUCTURE; MUSCARINIC ANTAGONISTS; PIPERIDINES; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC;

EID: 0033584151     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00327-3     Document Type: Article

References (8)

1. Doods, H. N. Drug News Perspect. 1992 July 345-352.
2. Alabaster, V. A. Life Sci. 1997, 61, 1053-1060.
3. Banyu Pharmaceutical Co., Ltd.; WO 9633973, 1996; Chem. Abstr. 1996, 126, 74747.
4. Mitsuya, M.; Tsuchiya, Y.; Kawakami, K.; Ohsawa, H.; Hattori, H.; Mase, T.; Satoh, A.; Funabashi, H.; Ohwaki, K.; Noguchi, K.; Tomimoto, K. Abstract of the 6th Annual Meeting of Division of Medicinal Chemistry, The Phamaceutical Society of Japan 1997 194-195.
5. Atkinson, E. R.; McRitchie, D. D.; Shoer, L. F.; Harris, L. S.; Archer, S.; Aceto, M. D.; Pearl, J.; Luduena, F. P. J. Med. Chem. 1977, 20, 1612-1623.
6. Seebach, D.; Naef, R.; Calderari, G. Tetrahedron 1984, 40, 1313-1324.
7. Similar observation has been reported. Ogawa, T.; Niwa, H.; Yamada, K. Tetrahedron 1993, 49, 1571-1578.
8. Detailed X-ray data will be deposited with the Cambridge Crystallographic Data Centre.