Expression of macrophage (Mφ) scavenger receptor, CD36, in cultured human aortic smooth muscle cells in association with expression of peroxisome proliferator activated receptor-γ, which regulates gain of Mφ-like phenotype in vitro, and its implication in atherogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 4, 2000, Pages 1027-1032

  Matsumoto, Kengo ^a   Hirano, Ken Ichi ^a   Nozaki, Shuichi ^a   Takamoto, Akiko ^a   Nishida, Makoto ^a   Nakagawa Toyama, Yumiko ^a   Janabi, Mohamed Yakub ^a   Ohya, Takeshi ^a   Yamashita, Shizuya ^a   Matsuzawa, Yuji ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

CD36; Foam cells; Oxidized LDL; Peroxisome proliferator activated receptor ; Scavenger receptors

Indexed keywords

CD36 ANTIGEN; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; SCAVENGER RECEPTOR; CELL RECEPTOR; MESSENGER RNA; TRANSCRIPTION FACTOR;

ARTICLE; ATHEROGENESIS; CELL TRANSFORMATION; CONTROLLED STUDY; FEMALE; FOAM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SMOOTH MUSCLE FIBER; ADULT; AORTA; ARTERIOSCLEROSIS; CELL CULTURE; CHEMISTRY; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; GENE EXPRESSION; GENETICS; INFANT; MACROPHAGE; METABOLISM; PATHOLOGY; PRESCHOOL CHILD; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR SMOOTH MUSCLE;

ADULT; ANTIGENS, CD36; AORTA; ARTERIOSCLEROSIS; CELLS, CULTURED; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; INFANT; MACROPHAGES; MALE; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH, VASCULAR; PHENOTYPE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0033625139     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.4.1027     Document Type: Article

References (26)

1. Greenwalt DE, Lipsky RH, Ockenhouse CF, Ikeda H, Tandon NN, Jamieson GA. Membrane glycoprotein CD36: a review of its role in adherence, signal transaction, and transfusion medicine. Blood. 1992; 80:1105-1115.
2. Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA. CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem. 1993;268:11811-11816.
3. Tomiyama Y, Take H, Ikeda H, Mitani T, Furubayashi T, Mizutani H, Yamamoto N, Tandon NN, Sekiguchi S, Jamieson GA, Kurata Y, Yonezawa T, Tarui S. Identification of the platelet-specific alloantigen, Naka, on platelet membrane glycoprotein IV. Blood. 1990;75:684-687.
4. Kashiwagi H, Honda S, Tomiyama Y, Mizutani H, Take H, Honda Y, Kosugi S, Kanayama Y, Kurata Y, Matsuzawa Y. A novel polymorphism in glycoprotein IV (replacement of proline-90 by serine) predominates in subjects with platelet GPIV deficiency. Thromb Haemost. 1993;69: 481-484.
5. Kashiwagi H, Tomiyama Y, Honda S, Kosugi S, Shiraga M, Nagao N, Sekiguchi S, Kanayama Y, Kurata Y, Matsuzawa Y. Molecular basis of CD36 deficiency: evidence that a 478C→T substitution (proline90→serine) in CD36 cDNA accounts for CD36 deficiency. J Clin Invest. 1995;95:1040-1046.
6. Kashiwagi H, Tomiyama Y, Nozaki S, Honda S, Kosugi S, Shiraga M, Nakagawa T, Nagao N, Kanakura Y, Kurata Y, Matsuzawa Y. A single nucleotide insertion in codon 317 of the CD36 gene leads to CD36 deficiency. Arterioscler Thromb Vasc Biol. 1996;16:1026-1032.
7. Nozaki S, Kashiwagi H, Yamashita S, Nakagawa T, Kostner B, Tomiyama Y, Ishigami M, Nakata A, Miyagawa J, Kameda-Takemura K, Kurata Y, Matsuzawa Y. Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects. J Clin Invest. 1995;96:1859-1865.
8. Nakagawa T, Nozaki S, Nishida M, Janabi MY, Tomiyama Y, Nakata A, Matsumoto K, Funahashi T, Kameda-Takemura K, Kurata Y, Yamashita S, Matsuzawa Y. Oxidized LDL increases and interferon-γ decreases expression of CD36 in human monocyte-derived macrophage. Arterioscler Thromb Vasc Biol. 1998;18:1350-1357.
9. Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR gamma. Cell. 1998;93:229-240.
10. Tontonoz P, Nagy L, Alvarez JG, Thomazy, VA, Evans RM. PPAR gamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998;93:241-252.
11. Bochaton-Piallat ML, Ropraz P, Gabbiani F, Gabbiani G. Phenotypic heterogeneity of rat arterial smooth muscle cell clones: implications for the development of experimental intimal thickening. Arterioscler Thromb Vasc Biol. 1996;16:815-820.
12. Chamley-Campbell J, Campbell GR, Ross R. The smooth muscle cell in culture. Physiol Rev. 1979;59:1-61.
13. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
14. Gong Q, Pitas RE. Synergistic effects of growth factors on the regulation of smooth muscle cell scavenger receptor activity. J Biol Chem. 1995; 270:21672-21678.
15. Hirano K, Yamashita S, Nakagawa Y, Ohya T, Matsuura F, Tsukamoto K, Okamoto Y, Matsuyama A, Matsumoto K, Miyagawa J, Matsuzawa Y. Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions. Circ Res. 1999;85:108-116.
16. Hirano K, Min J, Funahashi T, Baunoch DA, Davidson NO. Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide. J Lipid Res. 1997;38:847-846.
17. Miyazaki A, Rahim AT, Ohta T, Morino Y, Horiuchi S. High density lipoprotein mediates selective reduction in cholesteryl esters from macrophage foam cells. Biochim Biophys Acta. 1992;1126:73-80.
18. Hirsch D, Stahl A, Lodish HF. A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A. 1998;95: 8625-8629.
19. Pearson A, Lux A, Krieger M. Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster. Proc Nad Acad Sci U S A.. 1995;92:4056-4060.
20. Ramprasad MP, Fischer W, Witztum JL, Sambrano GR, Quehenberger O, Steinberg D. The 94-to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68. Proc Natl Acad Sci U S A. 1995;92:9580-9584.
21. Nakata A, Nakagawa Y, Nishida M, Nozaki S, Miyagawa J, Nakagawa T, Tamura R, Matsumoto K, Kameda-Takemura K, Yamashita S, Matsuzawa Y. CD36, a novel receptor for oxidized low-density lipoproteins, is highly expressed on lipid-laden macrophages in human atherosclerotic aorta. Arterioscler Thromb Vasc Biol. 1999;19: 1333-1339.
22. Nishimura N, Harada-Shiba M, Tajima S, Sugano R, Yamamura T, Qiang QZ, Yamamoto A. Acquisition of secretion of transforming growth factor-beta 1 leads to autonomous suppression of scavenger receptor activity in a monocyte-macrophage cell line, THP-1. J Biol Chem. 1998; 273:1562-1567.
23. Inaba T, Gotoda T, Harada K, Shimada M, Ohsuga J, Ishibashi S, Yazaki Y, Yamada N. Induction of sustained expression of proto-oncogene c-fms by platelet-derived growth factor, epidermal growth factor, and basic fibroblast growth factor, and its suppression by interferon-γ and macrophage colony-stimulating factor in human aortic medial smooth muscle cells. J Clin Invest. 1995;95:1133-1139.
24. Gittenberger-de Groot AC, DeRuiter MC, Bergwerff M, Poelmann RE. Smooth muscle cell origin and its relation to heterogeneity in development and disease. Arterioscler Thromb Vasc Biol. 1999;19:1589-1594.
25. Kirby ML, Waldo KL. Neural crest and cardiovascular patterning. Circ Res. 1995;77:211-215.
26. Ricote M, Huang J, Fajas L, Li A, Welch J, Najib J, Witztum JL, Auwerx J, Palinski W, Glass CK. Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc Natl Acad Sci U S A. 1998;95:7614-7619.