The effect of 17β-estradiol and α-tocopherol on the oxidation of LDL cholesterol from postmenopausal women and the minor effect of γ-tocopherol and melatonin

Menopause

Volumn 7, Issue 2, 2000, Pages 112-116

  Arteaga, Eugenio ^a   Rojas, Auristela ^a   Villaseca, Paulina ^a   Bianchi, Marcelo ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Antioxidants; Estradiol; Lipid peroxidation; Melatonin; Tocopherol; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; ESTRADIOL; GAMMA TOCOPHEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; MELATONIN; ANTIOXIDANT;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; FEMALE; HUMAN; HUMAN EXPERIMENT; LIPID PEROXIDATION; NORMAL HUMAN; POSTMENOPAUSE; BLOOD; MIDDLE AGED;

ANTIOXIDANTS; CHOLESTEROL, LDL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; HUMANS; LIPID PEROXIDATION; MELATONIN; MIDDLE AGED; VITAMIN E;

EID: 0033624861     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042192-200007020-00007     Document Type: Article

References (18)

1. Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated low-density lipoproteins, producing massive cholesterol deposition. Proc Natl Acad Sci USA 1979;76(1):333-7.
2. Witztum JL, Steinberg D. Role of oxidized low-density lipoprotein in atherogenesis. J Clin Invest 1991;88:1785-92.
3. Palinski W. Lipoprotein oxidation: mechanisms and implications for atherogenesis. In: Born GVR, Schwartz CJ, eds. New Horizons in Coronary Heart Disease. London: Current Science Ltd., 1993:13.1-13.12.
4. Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low-density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low-density lipoprotein phospholipids. Proc Natl Acad Sci U S A 1984;81(12):3883-7.
5. Esterbauer H, Puhl H, Dieber-Rotheneder M, Waeg G, Rabl H. Effect of antioxidants on oxidative modification of LDL. Ann Med 1991;23(5):573-81.
6. Subbiah MT, Kessel B, Agrawal M, Rajan R, Abplanalp W, Rymaszewski Z. Antioxidant potential of specific estrogens and lipid peroxidation. J Clin Endocrinol Metab 1993;77:1095-7.
7. Arteaga E, Rojas A, Villaseca P, Bianchi M, Arteaga A, Duran D. In vitro effect of estradiol, progesterone, testosterone and of combined estradiol/progestins on low density lipoprotein (LDL) oxidation in postmenopausal women. Menopause 1998;5:1-8.
8. Sack MN, Rader DJ, Cannon RO III. Oestrogen and inhibition of low-density lipoproteins in postmenopausal women. Lancet 1994;343:269-70.
9. Shwaery GT, Vita JA, Keaney JF Jr. Antioxidant protection of LDL by physiologic concentrations of estrogens is specific for 17-beta-estradiol. Atherosclerosis 1998;138:255-62.
10. Jha P, Flather M, Lonn E, Farkouh M, Yusuf S. The antioxidant vitamins and cardiovascular disease: a critical review of epidemiologic and clinical trial data. Ann Intern Med 1995;123:860-72.
11. Cagnoni ML, Lombardi A, Cerinic MC, Dedola GL, Pignone A. Melatonin for treatment of chronic refractory sarcoidosis. Lancet 1995;346(8984):1229-30.
12. Reiter RJ. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 1995;9:526-33.
13. Reppert SM, Weaver DR. Melatonin madness. Cell 1995;83:1050-62.
14. Arteaga E, Villaseca P, Rojas A, Arteaga A, Blanchi M. Comparación de la acción antioxidante de estriol y estradiol in vitro sobre lipoproteínas de baja densidad en mujeres post-menopáusicas. Rev Med Chile 1998;126:481-7.
15. Arteaga E, Villaseca P, Rojas A, Bianchi M, Arteaga A. Comparison of the in vitro antioxidant effect of estradiol, oestrone, oestriol, equiline, alpha tocopherol and melatonin on LDL-cholesterol in postmenopausal women. J Br Menopause Soc 1998;4(Suppl. 1):22-3.
16. Abuja PM, Liebmann P, Hayn M, Schauenstein K, Esterbauer H. Antioxidant role of melatonin in lipid peroxidation on human LDL. FEBS Lett 1997;413(2):289-93.
17. Reaven PD, Khouw A, Beltz WF, Parthasarathy S, Witztum JL. Effect of dietary antioxidant combinations in humans: protection of LDL by vitamin E but not by beta-carotene. Arterioscler Thromb 1993;13:590-600.
18. Mosca L, Rubenfire M, Mandel C, et al. Antioxidant nutrient supplementation reduces the susceptibility of low-density lipoprotein to oxidation in patients with coronary artery disease. J Am Coll Cardiol 1997;30(2):392-9.