Effects of the 5HT(1A) agonist/antagonist BMY 7378 on light-induced phase advances in hamster circadian activity rhythms during aging

Journal of Biological Rhythms

Volumn 15, Issue 4, 2000, Pages 300-305

  Byku, Mirnela ^a   Gannon, Robert L ^a  

^a DOWLING COLLEGE   (United States)

Author keywords

Aging; Chronobiotic; Circadian rhythms; Raphe; Serotonin; Suprachiasmatic nucleus

Indexed keywords

CRICETINAE; RODENTIA;

8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; PIPERAZINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

AGING; ANIMAL; ARTICLE; CIRCADIAN RHYTHM; DRUG EFFECT; HAMSTER; HUMAN; LIGHT; MALE; MOTOR ACTIVITY; PHOTOPERIODICITY; PHYSIOLOGY; SYRIAN HAMSTER;

AGING; ANIMALS; CIRCADIAN RHYTHM; CRICETINAE; HUMANS; LIGHT; MALE; MESOCRICETUS; MOTOR ACTIVITY; PHOTOPERIOD; PIPERAZINES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0033624496     PISSN: 07487304     EISSN: None     Source Type: Journal    
DOI: 10.1177/074873000129001404     Document Type: Article

References (35)

1. Brock MA (1991) Chronobiology and aging. J Am Geriatr Soc 39:74-91.
2. Challet E, Scarbrough K, Penev PD, and Turek FW (1998) Roles of suprachiasmatic nuclei and intergeniculate leaflets in mediating the phase-shifting effects of a serotonergic agonist and their photic modulation during subjective day. J Biol Rhythms 12:410-421.
3. Czeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Rimmer DW, Ronda JM, Silva EJ, Allan JS, Emens JS, Dijk D-J, and Kronauer RE (1999) Stability, precision, and near-24-hour period of the human circadian pacemaker. Science 284:2177-2181.
4. Czeisler CA, Dumont M, Duffy JF, Steinberg JD, Richardson GS, Brown EN, Sanchez R, Rios CD, and Ronda JM (1992) Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet 340:933-936.
5. Davis FC and Viswanathan N (1998) Stability of circadian timing with age in Syrian hamsters. Am J Physiol 275(Regul Integr Comp Physiol 44):R960-R968.
6. Dijk D-J and Duffy JF (1999) Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics. Ann Med 31:130-140.
7. Dudley TE, DiNardo LA, and Glass JD (1998) Endogenous regulation of serotonin release in the hamster suprachiasmatic nucleus. J Neurosci 18:5045-5052.
8. Dudley TE, DiNardo LA, and Glass JD (1999) In vivo assessment of the midbrain raphe nuclear regulation of serotonin release in the hamster suprachiasmatic nucleus. J Neurophysiol 81:1469-1477.
9. 1A receptors in discrete regions of the circadian timing system in hamsters. Brain Res 829:39-45.
10. Edelstein K and Amir S (1999) The role of the intergeniculate leaflet in entrainment of circadian rhythms to a skeleton photoperiod. J Neurosci 19:372-380.
11. 1A agonists/antagonists potentiate light-induced phase shifts of hamster circadian activity rhythms. Trans Soc Neurosci 21:180.
12. Greuel JM and Glaser T (1992) The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur J Pharmacol 211:211-219.
13. Johnson RF, Moore RY, and Morin LP (1988) Loss of entrainment and anatomical plasticity after lesions of the hamster retinohypothalamic tract. Brain Res 460:297-313.
14. A receptor-activated current in cultured rat suprachiasmatic neurones. J Physiol 478:67-73.
15. Lovenberg TW, Baron BM, de Lecea L, Miller JD, Prosser RA, Rea MA, Foye PE, Racke M, Slone AL, Siegel BW, Danielson PE, Sutcliffe JG, and Erlander MG (1993) A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron 11:449-458.
16. Meyer-Bernstein EL and Morin LP (1996) Differential serotonergic innervation of the suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm modulation. J Neurosci 16:2097-2111.
17. Meyer-Bernstein EL and Morin LP (1999) Electrical stimulation of the median or dorsal raphe nuclei reduces light-induced fos protein in the suprachiasmatic nucleus and causes circadian activity rhythm phase shifts. Neuroscience 92:267-279.
18. Millan MJ, Canton H, Gobert A, Lejeune F, Rivet J-M, Bervoets K, Broccco M, Widdowson P, Mennini T, Audinot V, Honore P, Renouard A, Le Marouille-Girardon S, Verriele L, Gressier H, and Peglion J-L (1994) Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: A comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther 268:337-352.
19. Morin LP (1988) Age-related changes in hamster circadian period, entrainment, and rhythm splitting. J Biol Rhythms 3:237-248.
20. Morin LP (1994) The circadian visual system. Brain Res Rev 67:102-127.
21. Morin LP (1999) Serotonin and the regulation of mammalian circadian rhythmicity. Ann Med 31:12-33.
22. Mrosovsky N (1996) Locomotor activity and non-photic influences on circadian clocks. Biol Rev 71:343-372.
23. Penev PD, Turek FW, Wallen EP, and Zee PC (1997) Aging alters the serotonergic modulation of light-induced phase advances in golden hamsters. Am J Physiol 272(Regul Integr Comp Physiol 41):R509-R513.
24. Penev PD, Zee PC, Wallen EP, and Turek FW (1995) Aging alters the phase-resetting properties of a serotonin agonist on hamster circadian rhythmicity. Am J Physiol 268(Regul Integr Comp Physiol 37):R293-R298.
25. Rea MA, Barrera J, Glass JD, and Gannon RL (1995) Serotonergic potentiation of photic phase shifts of the circadian activity rhythm. Neuroreport 6:1289-1292.
26. Rosenberg RS, Zee PC, and Turek FW (1991) Phase response curves to light in young and old hamsters. Am J Physiol 261(Regul Integr Comp Physiol 30):R491-R495.
27. Scarbrough K, Losee-Olson S, Wallen EP, and Turek FW (1997) Aging and photoperiod affect entrainment and quantitative aspects of locomotor behavior in Syrian hamsters. Am J Physiol 272(Regul Integr Comp Physiol 41):R1219-R1225.
28. Schwartz WJ (1993) A clinician's primer on the circadian clock: Its localization, function, and resetting. Adv Intern Med 38:81-106.
29. Sumova A, Maywood ES, Selvage D, Ebling FJP, and Hastings MH (1996) Serotonergic antagonists impair arousal-induced phase shifts of the circadian system of the Syrian hamster. Brain Res 709:88-96.
30. Tominaga K, Shibata S, Ueki S, and Watanabe S (1992) Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters. Eur J Pharmacol 214:79-84.
31. Van Reeth O, Zhang Y, Zee PC, and Turek FW (1992) Aging alters feedback effects of the activity-rest cycle on the circadian clock. Am J Physiol 263(Regul Integr Comp Physiol 32):R981-R986.
32. Weber ET, Cannon RL, Cagle MA, and Rea MA (1997) Pindolol and propranolol attenuate light-induced phase shifts of the circadian activity rhythm in hamster via a putative serotonergic mechanism. Trans Soc Neurosci 23:240.
33. Weber ET, Gannon RL, and Rea MA (1998) Local administration of serotonin agonists blocks light-induced phase advances of the circadian activity rhythm in the hamster. J Biol Rhythms 13:209-218.
34. Ying SW and Rusak B (1997) 5-HT7 receptors mediate serotonergic effects on light-sensitive suprachiasmatic nucleus neurons. Brain Res 755:246-254.
35. Zee PC, Rosenberg RS, and Turek FW (1992) Effects of aging on entrainment and rate of resynchronization of circadian locomotor activity. Am J Physiol 263(Regul Integr Comp Physiol 32):R1099-R1103.