Pharmacokinetics of the anticoagulant 14C-DX-9065a in the healthy male volunteer after a single intravenous dose

Xenobiotica

Volumn 30, Issue 5, 2000, Pages 515-521

  Murayama, N ^a   McMahon, H ^a   Young, C G ^a   McCracken, N W ^a   Okamura, Y ^a   Hakusui, H ^a   Tanaka, M ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; ANTICOAGULANT AGENT; CARBON; NAPHTHALENE DERIVATIVE; PROPIONIC ACID DERIVATIVE;

ADULT; ARTICLE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; HUMAN; KIDNEY CLEARANCE; NORMAL HUMAN; URINARY EXCRETION; ANIMAL; BLOOD; FECES; HAPLORHINI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIDDLE AGED; RAT; TIME; URINE;

ADULT; ANIMALS; ANTICOAGULANTS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; HAPLORHINI; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; NAPHTHALENES; PROPIONIC ACIDS; RATS; TIME FACTORS;

EID: 0033623976     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982500237514     Document Type: Article

References (11)

1. X-ray structure of active site-inhibited clotting factor Xa
2. Physiological parameters in laboratory animals and humans
3. Inhibition of thrombin generation effectively prevents thrombus formation without aggravation of bleeding
4. DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for factor Xa.
5. DX-9065a, an orally active, specific inhibitor of factor Xa, inhibits thrombosis without affecting bleeding time in rats
6. Human pharmacokinetics, pharmacodynamics, and tolerability of activated factor Xa inhibitor DX-9065a
7. Proposed cation-π mediated binding by factor Xa: A novel enzymatic mechanism for molecular recognition
8. Antithrombotic and hemorrhagic effects of DX-9065a, direct and selective factor Xa inhibitor: Comparison with a direct thrombin inhibitor and antithrombin III-dependent anticoagulants
9. Radioimmunoassay method for DX-9065a, an anticoagulant agent. Development, evaluation and application to human plasma
10. Tolerability, pharmacokinetics and pharmacodynamics of DX-9065a, a new synthetic, potent and specific factor Xa inhibitor, in healthy male volunteers
11. Crystal structures of factor Xa specific inhibitors in complex with trypsin: Structural grounds for inhibition of factor Xa and selectivity against thrombin