-
1
-
-
0028138379
-
Toward an integrated discovery and development program in Alzheimer's disease: The amyloid hypothesis
-
Greenberg, B. and Murphy, M. 1994. Toward an integrated discovery and development program in Alzheimer's disease: The amyloid hypothesis. Neurobiol. Aging 15:S105-109.
-
(1994)
Neurobiol. Aging
, vol.15
, pp. S105-109
-
-
Greenberg, B.1
Murphy, M.2
-
2
-
-
0028123071
-
Alzheimer's disease: A central role for amyloid
-
Selkoe, D. 1994. Alzheimer's disease: a central role for amyloid. J. Neuropathol. Exp. Neurol. 53:438-447.
-
(1994)
J. Neuropathol. Exp. Neurol.
, vol.53
, pp. 438-447
-
-
Selkoe, D.1
-
3
-
-
0026760261
-
Production of the Alzheimer amyloid β protein by normal proteolytic processing
-
Shoji, M., Golde, T., Ghiso, J., Cheung, T., Estus, S., Shaffer, L., Cai, X-D., McKay, D., Tintner, R., Frangione, B., and Younkin, S. 1992. Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 258:126-129.
-
(1992)
Science
, vol.258
, pp. 126-129
-
-
Shoji, M.1
Golde, T.2
Ghiso, J.3
Cheung, T.4
Estus, S.5
Shaffer, L.6
Cai, X.-D.7
McKay, D.8
Tintner, R.9
Frangione, B.10
Younkin, S.11
-
4
-
-
0026646604
-
Amyloid β-peptide is produced by cultured cells during normal metabolism
-
Haass, C., Schlossmacher, M., Hung, A., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B., Lieberburg, I., Koo, E., Schenk, D., Teplow, D., and Selkoe, D. 1992. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature London 359:322-325.
-
(1992)
Nature London
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.2
Hung, A.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.6
Lieberburg, I.7
Koo, E.8
Schenk, D.9
Teplow, D.10
Selkoe, D.11
-
5
-
-
0026646605
-
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
-
Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M., Whaley, J., Swindle-Hurst, C., McCormack, R., Wolfert, R., Selkoe, D., Lieberburg, I., and Schenk, D. 1992. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature London 359:325-327.
-
(1992)
Nature London
, vol.359
, pp. 325-327
-
-
Seubert, P.1
Vigo-Pelfrey, C.2
Esch, F.3
Lee, M.4
Dovey, H.5
Davis, D.6
Sinha, S.7
Schlossmacher, M.8
Whaley, J.9
Swindle-Hurst, C.10
McCormack, R.11
Wolfert, R.12
Selkoe, D.13
Lieberburg, I.14
Schenk, D.15
-
6
-
-
0030601055
-
Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: Association with high density lipoproteins
-
Koudinov, A., Koudinova, N., Kumar, A., Beavis, R., and Ghiso, J. 1996. Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins. Biochem. Biophys. Res. Commun. 223:592-597.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.223
, pp. 592-597
-
-
Koudinov, A.1
Koudinova, N.2
Kumar, A.3
Beavis, R.4
Ghiso, J.5
-
7
-
-
0032559575
-
Alzheimer's amyloid β interaction with normal human plasma high density lipoprotein: Association with apolipoprotein and lipids
-
Koudinov, A. R., Berezov, T. T., Kumar, A., and Koudinova, N. V. 1998. Alzheimer's amyloid β interaction with normal human plasma high density lipoprotein: association with apolipoprotein and lipids. Clin. Chim. Acta 270:75-84.
-
(1998)
Clin. Chim. Acta
, vol.270
, pp. 75-84
-
-
Koudinov, A.R.1
Berezov, T.T.2
Kumar, A.3
Koudinova, N.V.4
-
8
-
-
0031148272
-
Soluble amyloid beta protein is secreted by HepG2 cells as an apolipoprotein
-
Koudinov, A. R. and Koudinova, N. V. 1997. Soluble amyloid beta protein is secreted by HepG2 cells as an apolipoprotein. Cell Biol. Internat. 25:265-271.
-
(1997)
Cell Biol. Internat.
, vol.25
, pp. 265-271
-
-
Koudinov, A.R.1
Koudinova, N.V.2
-
9
-
-
0021704422
-
Plasma lipoproteins: Apolipoprotein structure and function
-
Mahley, R., Innerarity, T., Rail, S., and Weisgraber, K. 1984. Plasma lipoproteins: apolipoprotein structure and function. J. Lipid Res. 25:1277-1294.
-
(1984)
J. Lipid Res.
, vol.25
, pp. 1277-1294
-
-
Mahley, R.1
Innerarity, T.2
Rail, S.3
Weisgraber, K.4
-
12
-
-
0022622788
-
Brain trace elements in Alzheimer's disease
-
Ehmann, W. D., Markesbery, W. R., Alauddin, M., Hossain, T. I., and Brubaker, E. H. 1986. Brain trace elements in Alzheimer's disease. Neurotoxicology 7:197-206.
-
(1986)
Neurotoxicology
, vol.7
, pp. 197-206
-
-
Ehmann, W.D.1
Markesbery, W.R.2
Alauddin, M.3
Hossain, T.I.4
Brubaker, E.H.5
-
14
-
-
0029090578
-
Breakdown of membrane phospholipids in Alzheimer's disease-involvement of excitatory amino-acid receptors
-
Farooqui, A. A., Wells, K., and Horrocks, L. A. 1995. Breakdown of membrane phospholipids in Alzheimer's disease-involvement of excitatory amino-acid receptors. Mol. Chem. Neuropathol. 25:155-173.
-
(1995)
Mol. Chem. Neuropathol.
, vol.25
, pp. 155-173
-
-
Farooqui, A.A.1
Wells, K.2
Horrocks, L.A.3
-
15
-
-
0026524681
-
Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol
-
Mason, R. P., Shoemaker, W. J., Shajenko, L., Chambers, T. E., and Herbette, L. G. 1992. Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol. Neurobiology Aging 13:413-418.
-
(1992)
Neurobiology Aging
, vol.13
, pp. 413-418
-
-
Mason, R.P.1
Shoemaker, W.J.2
Shajenko, L.3
Chambers, T.E.4
Herbette, L.G.5
-
16
-
-
0026513962
-
Evidence for a membrane defect in Alzheimer disease brain
-
Nithsch, R. M., Blusztajn, J. K., Pittas, A. G., Slack, B. E., and Wurtman, R. J. 1992. Evidence for a membrane defect in Alzheimer disease brain. Proc. Natl. Acad. Sci. USA. 89:1671-1675.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 1671-1675
-
-
Nithsch, R.M.1
Blusztajn, J.K.2
Pittas, A.G.3
Slack, B.E.4
Wurtman, R.J.5
-
17
-
-
0030915855
-
Oxidative stress hypothesis in Alzheimer's disease
-
Markesbery, W. R. 1997. Oxidative stress hypothesis in Alzheimer's disease. Free Rad. Biol. Med. 23:134-147.
-
(1997)
Free Rad. Biol. Med.
, vol.23
, pp. 134-147
-
-
Markesbery, W.R.1
-
18
-
-
0028129137
-
Evidence of an oxidative challenge in the Alzheimer's brain
-
Balasz, L. and Leon, M. 1994. Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem. Res. 19:1131-1137.
-
(1994)
Neurochem. Res.
, vol.19
, pp. 1131-1137
-
-
Balasz, L.1
Leon, M.2
-
19
-
-
0014935332
-
Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain
-
Bazan, N. G. Jr. 1970. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim. Biophys. Acta. 218:1-10.
-
(1970)
Biochim. Biophys. Acta.
, vol.218
, pp. 1-10
-
-
Bazan, N.G.1
-
20
-
-
0023929599
-
The uteroplacental ischemic rat embryo: A. Lactic acid accumulation and prostaglandin formation in the fetal brain
-
Magal, E., Goldin, E., Harel, S., and Yavin, E. 1988. The uteroplacental ischemic rat embryo: A. Lactic acid accumulation and prostaglandin formation in the fetal brain. J. Neurochem. 51: 75-80.
-
(1988)
J. Neurochem.
, vol.51
, pp. 75-80
-
-
Magal, E.1
Goldin, E.2
Harel, S.3
Yavin, E.4
-
21
-
-
0031048426
-
Death in early postmitotic cerebral cortex cells after transient oxygen and glucose deprivation is apoptotic
-
Yavin, E. and Marie-Billia, D. 1997. Death in early postmitotic cerebral cortex cells after transient oxygen and glucose deprivation is apoptotic. J. Neurosci. Res. 47:471-478.
-
(1997)
J. Neurosci. Res.
, vol.47
, pp. 471-478
-
-
Yavin, E.1
Marie-Billia, D.2
-
22
-
-
0018128226
-
Lipid extraction of tissues with a low toxicity solvent
-
Hajra, A. and Radin, N. 1978. Lipid extraction of tissues with a low toxicity solvent. Anal. Biochem. 90:420-426.
-
(1978)
Anal. Biochem.
, vol.90
, pp. 420-426
-
-
Hajra, A.1
Radin, N.2
-
23
-
-
70449158340
-
A simple method for the isolation and purification of total lipids from animal tissues
-
Folch, J., Lees, M., and Sloane-Stanley, G. H. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-509.
-
(1957)
J. Biol. Chem.
, vol.226
, pp. 497-509
-
-
Folch, J.1
Lees, M.2
Sloane-Stanley, G.H.3
-
24
-
-
0033232919
-
Unilateral GluR2(B) hippocampal knockdown: A possible novel partial seizure model in young rat
-
Friedman, L. K., Koudinov, A. R. 1999. Unilateral GluR2(B) hippocampal knockdown: a possible novel partial seizure model in young rat. J. Neurosci. 19, 9412-9425.
-
(1999)
J. Neurosci.
, vol.19
, pp. 9412-9425
-
-
Friedman, L.K.1
Koudinov, A.R.2
-
25
-
-
0030726780
-
Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth
-
Araki, W., Wurtman, R. J. 1997. Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth. Proc Natl Acad Sci U S A, 94:11946-11950.
-
(1997)
Proc Natl Acad Sci u s a
, vol.94
, pp. 11946-11950
-
-
Araki, W.1
Wurtman, R.J.2
-
26
-
-
0024598955
-
Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of corpus striatum
-
Ulus, I. H, Wurtman, R. J., Mauron, C., Blusztajn, J. K. 1989. Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of corpus striatum. Brain Res. 484:217-26
-
(1989)
Brain Res.
, vol.484
, pp. 217-226
-
-
Ulus, I.H.1
Wurtman, R.J.2
Mauron, C.3
Blusztajn, J.K.4
-
27
-
-
0020040981
-
Eicosanoids: Prostaglandins, thromboxane, leukotrienes and other derivatives of carbon- 20 unsaturated fatty acids
-
Wolfe, L. S. 1982. Eicosanoids: Prostaglandins, thromboxane, leukotrienes and other derivatives of carbon- 20 unsaturated fatty acids. J. Neurochem. 38:1-14.
-
(1982)
J. Neurochem.
, vol.38
, pp. 1-14
-
-
Wolfe, L.S.1
-
28
-
-
0343881470
-
Involvement of arachidonic acid and platelet-activating factor in the response of the nervous system to ischemia and convulsions. In Lipid mediators in ischemic brain damage and experimental epilepsy
-
Bazan, N. G. 1990. Involvement of arachidonic acid and platelet-activating factor in the response of the nervous system to ischemia and convulsions. In Lipid mediators in ischemic brain damage and experimental epilepsy. New Trends Lipid Mediators Res. 4:241-252.
-
(1990)
New Trends Lipid Mediators Res.
, vol.4
, pp. 241-252
-
-
Bazan, N.G.1
-
29
-
-
0017745032
-
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum
-
Takai, Y., Kishimoto, A., Inoue, M., and Nishizuka, Y. 1977. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum. J. Biol. Chem. 252:7603-7609.
-
(1977)
J. Biol. Chem.
, vol.252
, pp. 7603-7609
-
-
Takai, Y.1
Kishimoto, A.2
Inoue, M.3
Nishizuka, Y.4
-
30
-
-
0022854828
-
Synaptic plasticity and protein kinase C
-
Routtenberg, A. 1986. Synaptic plasticity and protein kinase C. Prog. Brain Res, 69:411-435.
-
(1986)
Prog. Brain Res
, vol.69
, pp. 411-435
-
-
Routtenberg, A.1
-
31
-
-
26544443671
-
Regulation of PKC and MAPK-related phosphorylation cascades by β amyloid 1-40 during oxygen deprivation in rat cerebral neurons
-
Kuperstein, F., Koudinova, N., and Yavin, E. 1998. Regulation of PKC and MAPK-related phosphorylation cascades by β amyloid 1-40 during oxygen deprivation in rat cerebral neurons. Neurosci Lett. 51, S24.
-
(1998)
Neurosci Lett.
, vol.51
, pp. S24
-
-
Kuperstein, F.1
Koudinova, N.2
Yavin, E.3
-
32
-
-
24844432104
-
Redistribution of phosphatidylethanolamine and phosphatidylserine precedes reperfusion-induced apoptosis
-
Maulik, N., Kagan, V. E., Tyurin, V. A., and Das, D. K. 1998. Redistribution of phosphatidylethanolamine and phosphatidylserine precedes reperfusion-induced apoptosis. Am. J. Physiol. 274:H242-248.
-
(1998)
Am. J. Physiol.
, vol.274
, pp. H242-248
-
-
Maulik, N.1
Kagan, V.E.2
Tyurin, V.A.3
Das, D.K.4
-
33
-
-
0030833577
-
Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: Implications for cerebral amyloid angiopathy
-
Urmoneit, B., Prikulis, I., Wihl, G., Durso, D., Frank, R., Heeren, J., Belsiegel, U., Prior, R. 1997. Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: Implications for cerebral amyloid angiopathy. Lab Investig. 77:157-166.
-
(1997)
Lab Investig.
, vol.77
, pp. 157-166
-
-
Urmoneit, B.1
Prikulis, I.2
Wihl, G.3
Durso, D.4
Frank, R.5
Heeren, J.6
Belsiegel, U.7
Prior, R.8
-
34
-
-
0033559412
-
Expression of human apolipoprotein e reduces amyloid-beta deposition in a mouse model of Alzheimer's disease
-
Holtzman, D. M., Bales, K. R., Wu, S., Bhat, P., Parsadanian, M., Pagan, A. M., Chang, L. K., Sun, Y. L., Paul, S. M. 1999. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease J. Clin. Investig. 103:R15-R21.
-
(1999)
J. Clin. Investig.
, vol.103
, pp. R15-R21
-
-
Holtzman, D.M.1
Bales, K.R.2
Wu, S.3
Bhat, P.4
Parsadanian, M.5
Pagan, A.M.6
Chang, L.K.7
Sun, Y.L.8
Paul, S.M.9
-
35
-
-
0031022729
-
Lipid peroxides are generated by fetal rat brain after episodes of global ischemia in utero
-
Glozman, S., and Yavin, E. 1997. Lipid peroxides are generated by fetal rat brain after episodes of global ischemia in utero. Neurochem. Res. 22:201-208.
-
(1997)
Neurochem. Res.
, vol.22
, pp. 201-208
-
-
Glozman, S.1
Yavin, E.2
-
36
-
-
0029803962
-
Prostacyclin accumulates in a rat model of uteroplacental insufficiency: Implications for intrauterine growth retardation
-
Hophy, M., Harel, S., and Yavin, E. 1996. Prostacyclin accumulates in a rat model of uteroplacental insufficiency: Implications for intrauterine growth retardation. Reprod. Fertil. Dev. 8:895-901.
-
(1996)
Reprod. Fertil. Dev.
, vol.8
, pp. 895-901
-
-
Hophy, M.1
Harel, S.2
Yavin, E.3
-
37
-
-
0027171266
-
Oxidants, antioxidants and the degenerative diseases of aging
-
Ames, B. N., Shigenage, M. K., and Hagen, T. M. 1993. Oxidants, antioxidants and the degenerative diseases of aging. Proc Natl Acad Sci USA. 90:7915-7922.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7915-7922
-
-
Ames, B.N.1
Shigenage, M.K.2
Hagen, T.M.3
-
38
-
-
0031981072
-
Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress
-
Smith, M. A., Hirai, K., Hsiao, K., Pappola, M., and Perry, G. 1998. Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress. J. Neurochem. 70:2212-2215.
-
(1998)
J. Neurochem.
, vol.70
, pp. 2212-2215
-
-
Smith, M.A.1
Hirai, K.2
Hsiao, K.3
Pappola, M.4
Perry, G.5
-
39
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu, Sn, superoxide dismutase mutation
-
Gurney, M. E., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y. et al. 1994. Motor neuron degeneration in mice that express a human Cu, Sn, superoxide dismutase mutation. Science 264:1 772-1775.
-
(1994)
Science
, vol.264
, pp. 1772-1775
-
-
Gurney, M.E.1
Chiu, A.Y.2
Dal Canto, M.C.3
Polchow, C.Y.4
-
40
-
-
0023818756
-
[31P] nuclear magnetic resonance study of the brain in Alzheimer's disease
-
Pettegrew, J. W., Moossy, J., Withers, G., McKeag, D., and Panchalingam, K. 1988. [31P] nuclear magnetic resonance study of the brain in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 47:235-248.
-
(1988)
J. Neuropathol. Exp. Neurol.
, vol.47
, pp. 235-248
-
-
Pettegrew, J.W.1
Moossy, J.2
Withers, G.3
McKeag, D.4
Panchalingam, K.5
-
41
-
-
0029665411
-
Quantitative H-1 and P-31 MRS of PCA extracts of postmortem Alzheimer's disease brain
-
Klunk, W. E., Panchalingam, K., McClure, R. J., and Pettegrew, J. W. 1996. Quantitative H-1 and P-31 MRS of PCA extracts of postmortem Alzheimer's disease brain. Neurobiology Aging 17:349-357.
-
(1996)
Neurobiology Aging
, vol.17
, pp. 349-357
-
-
Klunk, W.E.1
Panchalingam, K.2
McClure, R.J.3
Pettegrew, J.W.4
|