Ca2+ entry but not Ca2+ release is necessary for desensitization of ET(A) receptors in airway epithelial cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 361, Issue 2, 2000, Pages 120-126

  Meyer, T ^a   Oles, M ^a   Pott, L ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Airway; Ca2+ signalling; Desensitization; Endothelin 1; Epithelial cell; Fura

Indexed keywords

ENDOTHELIN A RECEPTOR; 1 (2 (3 (4 METHOXYPHENYL)PROPOXY) 4 METHOXYPHENYLETHYL) 1H IMIDAZOLE; 1-(2-(3-(4-METHOXYPHENYL)PROPOXY)-4-METHOXYPHENYLETHYL)-1H-IMIDAZOLE; CALCIUM; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; IMIDAZOLE DERIVATIVE;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; HUMAN; HUMAN CELL; RECEPTOR DOWN REGULATION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; CALCIUM SIGNALING; CELL CULTURE; DRUG EFFECT; METABOLISM; PHYSIOLOGY; TRACHEA;

CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; ENDOTHELIN-1; HUMANS; IMIDAZOLES; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; TRACHEA;

EID: 0033621873     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900183     Document Type: Article

References (26)

1. Artalejo CR, Elhamdani A, Palfrey HC (1996) Calmodulin is the divalent cation receptor for rapid endocytosis, but not exocytosis, in adrenal chromaffin cells. Cell 16:195-205
2. 2+ signalling takes the local route. Curr Opin Neurobiol 2:302-307
3. i-transients in cardiac myocytes measured by means of a fast fura-2 technique. Cell Calcium 11:385-396
4. Bhowmick N, Narayan P, Puett D (1998) The endothelin subtype A receptor undergoes agonist-and antagonist-mediated internalization in the absence of signaling. Endocrinology 139: 3185-3192
5. Black PN, Ghatei MA, Takahashi K, Bretherton-Watt D, Krausz T, Dollery CT, Bloom SR (1989) Formation of endothelin by cultured airway epithelial cells. FEBS Lett 255:129-132
6. Bünemann M, Lee KB, Pals-Rylaarsdam R, Roseberry AG, Hosey MM (1999) Desensitization of G-protein-coupled receptors in the cardiovascular system. Annu Rev Physiol 61:169-192
7. A receptors. J Biol Chem 270: 10855-10860
8. DebBurman SK, Hosey MM (1995) Role of protein phosphorylation in the desensitization of muscarinic receptors. In: Wess J (ed) Molecular mechanism of muscarinic receptor function. Landes, Austin, pp 209-226
9. Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ (1997) Phosphorylation and desensitization of human endothelin A and B receptors - evidence for G protein-coupled receptor kinase specificity. J Biol Chem 272:17734-17743
10. 2+-permeable nonselective cation channel by endothelin-1 in A7r5 cells. Br J Pharmacol 124:1541-1549
11. 2+ channel blocker, LOE 908. Br J Pharmacol 126:1107-1114
12. Kobayashi S, Tang R, Wang B, Opgenorth T, Langenstroer P, Shapiro E, Lepor H (1994) Binding and functional properties of endothelin receptor subtypes in the human prostate. Mol Pharmacol 45:306-311
13. Krupnick JG, Benovic JL (1998) The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 38:289-319
14. McMillen MA, Sumpio BE (1995) Endothelins: polyfunctional cytokines. J Am Coll Surg 180:621-637
15. Merritt JE, Armstrong WP, Benham CD, Hallam TJ, Jacob R, Jaxa-Chamiec A, Leigh BK, McCarthy SA, Moores KE, Rink TJ (1990) SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem J 271:515-522
16. Ninomiya H, Yu X-Y, Uchida Y, Hasegawa S, Spannhake EW (1995) Specific binding of endothelin-1 to canine tracheal epithelial cells in culture. Am J Physiol 268:L424-L431
17. 2+ signals induced by endothelin-1 in a human bronchial epithelial cell line. Cell Calcium 21:221-231
18. A endothelin receptor-mediated negative chronotropic response in right atria-species difference and intracellular mechanisms. Br J Pharmacol 125:787-797
19. Pitcher JA, Freedman NJ, Lefkowitz RJ (1998) G protein-coupled receptor kinases. Annu Rev Biochem 67:653-692
20. Pollock DM, Keith TL, Highsmith RF (1995) Endothelin receptors and calcium signaling. FASEB J 9:1196-1204
21. Stephenson RP (1956) A modification of receptor theory. Br J Pharmacol 11:379-393
22. 2+ mobilization in smooth muscle cells by protein kinase C. Am J Physiol 266:C1560-C1567
23. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 322:411-415
24. Yang CM, Ong R, Chen Y-C, Hsieh J-T, Tsao H-L, Tsai C-T (1995) Effect of phorbol ester on phosphoinositide hydrolysis and calcium mobilization induced by endothelin-1 in cultured canine tracheal smooth muscle cells. Cell Calcium 17:129-140
25. Yankaskas JR, Haizlip JE, Conrad M, Koval D, Lazarowski E, Paradiso AM, Rinehart CA Jr, Sarkadi B, Schlegel R, Boucher RC (1993) Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype. Am J Physiol 264: C1219-C1230
26. - channels, resulting in spontaneous transient currents in guinea-pig tracheal myocytes. J Physiol (Lond) 513:711-718