Probing the folding pathways of long R3 insulin-like growth factor-I (LR3IGF-I) and IGF-I via capture and identification of disulfide intermediates by cyanylation methodology and mass spectrometry

Journal of Biological Chemistry

Volumn 274, Issue 53, 1999, Pages 37598-37604

  Yang, Ying ^a,c   Wu, Jiang ^a,d   Watson, J Throck ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; GLUTATHIONE PEROXIDASE; LONG R3 INSULIN LIKE GROWTH FACTOR 1; SOMATOMEDIN C; SOMATOMEDIN C DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL MODIFICATION; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYANIDES; DISULFIDES; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN FOLDING; RECOMBINANT PROTEINS;

EID: 0033621322     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.53.37598     Document Type: Article

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