Ribozymes - Why so many, why so few?

Molecules and Cells

Volumn 9, Issue 5, 1999, Pages 459-463

  Schmidt, Francis J ^a  

^a University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACID; RIBOZYME;

BINDING SITE; BIOGENESIS; BIOLOGICAL MODEL; CATALYSIS; CHEMISTRY; CLASSIFICATION; CONFORMATION; GENETIC SELECTION; MOLECULAR EVOLUTION; MOLECULAR WEIGHT; PHYSIOLOGY; REVIEW; TRANSACTIVATION;

BINDING SITES; BIOGENESIS; CATALYSIS; EVOLUTION, MOLECULAR; MODELS, GENETIC; MOLECULAR WEIGHT; NUCLEIC ACID CONFORMATION; NUCLEIC ACIDS; RNA, CATALYTIC; SELECTION (GENETICS); TRANS-ACTIVATION (GENETICS);

EID: 0033621214     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (21)

1. Anders, E., Shearer, C. K., Papike, J. J., Bell, J. F., Clemett, S. J., Zare, R. N., McKay, D. S., Thomas-Keprta, K. L., Romanek, C. S., Gibson, E. K. Jr., and Vali, H. (1996). Evaluating the evidence for past life on Mars [letters] Science 274, 2119-2125.
2. Beaudry, A. A. and Joyce, G. F. (1992) Directed evolution of an RNA enzyme. Science 257, 635-641.
3. Dange, V., Van Atta, R. B., and Hecht, S. M. (1990) A Mn2(+)-dependent ribozyme. Science 248, 585-588.
4. Eigen, M. (1992) Steps Toward Life. Oxford University Press, New York.
5. Ekland, E. H., Szostak, J. W., and Bartel, D. P. (1995) Structurally complex and highly active RNA ligases derived from random RNA sequences. Science 269, 364-370.
6. Ellington, A. D. and Szostak, J. W. (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346, 818-822.
7. Gold, L., Polisy, B., Uhlenbeck, O., and Yarus, M. (1995) Diversity of oligonucleotide functions. Ann. Rev. of Biochem. 64, 763-797.
8. Golden, B. L., Gooding, A. R., Podell, E. R., and Cech, T. R. (1998) A preorganized active site in the crystal structure of the Tetrahymena ribozyme. Science 282, 251-252.
9. Green, R. and Szostak, J. W. (1992) Selection of a ribozyme that functions as a superior template in a self-copying reaction. Science 258, 1910-1915.
10. Herschlag, D. and Cech, T. R. (1990) Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site. Biochemistry 29, 10159-10171.
11. Joyce, G. F. and Orgel, L. E. (1999) Prospects for understanding the RNA world, in The RNA World, Gesteland, R. E., Cech, T. R., and Atkins, J. F. (eds.), 2nd ed., pp. 49-77, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
12. Kazakov, S. and Altman, S. (1992) A trinucleotide can promote metal ion-dependent specific cleavage of RNA. Proc. Natl. Acad. Sci. USA 89, 7939-7943.
13. Landweber, L. F. and Pokrovskaya, I. D. (1999) Emergence of a dual-catalytic RNA with metal-specific cleavage and ligase activities: The spandrels of RNA evolution. Proc. Natl. Acad. Sci. USA 96, 173-178.
14. Narliker, G. H. and Herschlag, D. (1998) Direct demonstration of the catalytic role of binding interactions in an enzymatic reaction. Biochemistry 37, 9902-9911.
15. Pan, T. and Uhlenbeck, O. C. (1992) A small metalloribozyme with a two-step mechanism. Nature 358, 560-563.
16. Sabeti, P. C., Unrau, P. J., and Bartel, D. P. (1997) Accessing rare activities from random RNA sequences: The importance of the length of molecules in the starting pool. Chemistry & Biology. 4, 767-774.
17. Schopf, J. W. and Packer, B. M. (1987) Early Archean (3.3-billion to 3.5-billion-year-old) microfossils from Warrawoona group, Australia. Science 237, 70-73.
18. Seaborg, D. M. (1999) Evolutionary Feedback: A new mechanism for stasis and punctuated evolutionary change based on integration of the organism. J. Theoret. Biol. 198, 1-26.
19. Tuerk, C. and Gold, L. (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249, 505-510.
20. Vaish, H. K., Kore, A. R., and Eckstein, R. (1998) Recent developments in the hammerhead ribozyme field. Nucl. Acids Res. 26, 5237-5242.
21. van der Horst, G., Christian, A., and Inoue T. (1991) Reconstitution of a group I intron self-splicing reaction with an activator RNA. Proc. Natl. Acad. Sci. USA. 88, 184-188.