Effects of endothelin-1 on duodenal bicarbonate secretion and mucosal integrity in rats

Chinese Journal of Physiology

Volumn 42, Issue 3, 1999, Pages 129-135

  Takeuchi, Koji ^a   Sugamoto, Shinichi ^a   Suzuki, Keizo ^a   Kawauchi, Shoji ^a   Furukawa, Osamu ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acid secretion; Duodenal lesion; Endothelin 1; HCO 3 secretion; Prostacyclin

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTIULCER AGENT; BICARBONATE; CYCLO(TRP ASP PRO VAL LEU); CYCLO(TRP-ASP-PRO-VAL-LEU); CYCLOPEPTIDE; DRUG DERIVATIVE; ENDOTHELIN 1; EPIRIZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTACYCLIN; TY 10957;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; DUODENUM; DUODENUM ULCER; INTESTINE MUCOSA; MALE; METABOLISM; PATHOLOGY; PH; RAT; SECRETION; SPRAGUE DAWLEY RAT; STOMACH ACID; VAGOTOMY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; ANTIHYPERTENSIVE AGENTS; BICARBONATES; DUODENAL ULCER; DUODENUM; ENDOTHELIN-1; EPIRIZOLE; EPOPROSTENOL; GASTRIC ACID; HYDROGEN-ION CONCENTRATION; INTESTINAL MUCOSA; MALE; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; VAGOTOMY;

EID: 0033618923     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Brown, J.F., Hanson, P.J. and Whittle, B.J.R. Nitric oxide donors increase mucus gel thickness in rat stomach. Eur. J. Pharmacol. 223: 103-104, 1992.
2. Chen, M.C., Amirian, D.A., Toomey, M., Sanders, M.J. and Soll, A. H. Prostanoid inhibit of canine parietal cells: Mediation by the inhibitory guanosine triphosphate-binding protein of adenylate cyclase. Gasrroenterology 94: 1121-1129, 1988.
3. De Nucci, G., Thomas, R., D'orleans-Juste, P., Antunes, E., Walder, C., Warner, T.D. and Vane, J.R. Press effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacycline and endothelium-derived relaxing factor. Proc. Natl. Acad. Sci. USA 85: 9797-9800, 1988.
4. Flemstrom, G. Gastroduodenal mucosal secretion of bicarbonate and mucus: Physiological control and stimulation by prostaglandins. Am. J. Med. 81: 18-22, 1986.
5. 3 H]BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype. Eur. J. Pharmacol. 274: 1-6, 1995.
6. Kato, S., Hirata, T. and Takeuchi, K. Nitric oxide, prostaglandin and sensory neurons in gastric mucosal blood flow response during acid secretion in rats. Gen. Pharmacol. 28: 513-519, 1997.
7. Koduru, S., Hirsch, A., McCuen, R. and Schubert, M. Endothelin, released from the fundus of the stomach, participates in the regulation of acid secrehon. Gastroenterology 114 (Abstract): A-182, 1998.
8. 2 on gastric secrehon. gastrin release, and mucosal blood flow in dogs. Dig. Dis. Sci. 25: 673-679, 1980.
9. Lerman, A., Hildebrand, F.C., Margulies, K.B., O'Marchu, B., Perrella, M.A., Heublein, D.M., Schwab, T.R. and Burnett, J.C. Endothelin: A new cardiovascular regulatory peptide. Mayo Clin. Proc. 65: 1441-1455, 1990.
10. Lippe, ThI. and Holzer, P. Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperemia due to acid back-diffusion. Br. J. Pharmacol. 105: 708-714, 1992.
11. MacNaughton, K., Cirino, G. and Wallace, J.L. Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach. Life Sci. 45: 1869-1876, 1989.
12. Masuda, E., Kawano, S., Nagano, K., Tsuji, S., Ishigami, Y., Tsujii, M., Hayashi, N., Fusamoto, H. and Kamata, T. Effect of intravascular ethanol on modulation of gastric mucosal integrity: possible role of endothelin-1. Am. J. Physiol. 262: G785-G790, 1992.
13. Miller, T.A. Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms. Am. J. Physiol. 245: G601-G623, 1983.
14. Moncada, S., Palmer, R.M.J. and Higgs, E.A. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109-142, 1993.
15. Morales, R. E., Johnson, B .R. and Szabo, S. Endothelin induces vascular and mucosal lesions, enhances the injury by HCI/ethanol. and antibody exerts gastroprotec-tion. FASEB J. 6: 2354-2360, 1992.
16. 3 receptors on gastric enterochromaffin-like cell carcinoid in afncan rodents. Gastroenterology 109: 341-347, 1995.
17. Okabe, S., Ishihara, Y., Inoo, H. and Tanaka, H. Mepirizole-induced duodenal ulcers in rats and their pathogenesis. Dig. Dis. Sci. 27: 242-249, 1982.
18. 2 derivative, on gastroduodenal lesions and secretory responses in the rat. Digestion 45: 61-71, 1990.
19. 2 . Eur J. Pharmacol. 252: 81-86, 1994.
20. Simson, J.N.L., Merhav, A. and Silen, W. Alkaline secretion by amphibian duodenum. III. Effects of DBcAMP, theophylline, and prostaglandins. Am. J. Physiol. 241: G528-G536, 1981.
21. Soll, A.H. and Whittle, B.J. Prostacyclin analogues inhibit canine parietal cell activity and cyclic AMP formation. Prostaglandins 21: 353-365, 1981.
22. Takeuchi, K., Niida, H., Ueshima, K. and Okabe, S. Determination of gastroduoenal alkaline response in the rat. J. Pharmacol. Method 24: 189-202, 1990.
23. - secretion in rats. J. Pharmacol. Exp. Ther. 266: 1512-1519, 1993.
24. - secretion by NG-nitro-L-arginine methyl ester an inhibitor of nitric oxide synthase in rats. Jpn. J. Pharmacol. 66: 295-302, 1994.
25. Takeuchi, K., Ohuchi, T. and Okabe, S. Effects of nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester on duodenal alkaline secretory and ulcerogenic responses induced by mepirizole in rats. Dig. Dis. Sci. 40: 670-677, 1995.
26. Takeuchi, K. and Okabe, S. Mechanism of gastric alkaline response in the stomach after damage: Roles of nitric oxide and prostaglandins. Dig. Dis. Sci. 40:865-871, 1995.
27. - secretory response to NG-nitro-L-arginine methyl ester in rats following repeated administration. J. Gastroent. Hepatology 11: 1164-1170, 1996.
28. Takeuchi, K., Yagi, K., Kato, S. and Ukawa, H. Role of prostaglandin E receptor subtypes in gastric and duodenal bicarbonate secretion in rats. Gastroenterology 113: 1553-1559, 1997.
29. Tanaka, H., Ueki, S., Ohno, T., Takeuchi, K. and Okabe, S. Pathogenic mechanisms involved in mepirizole-induced duodenal damage in the rat. Jpn. J. Pharmacol. 42: 383-396, 1986.
30. Ueshima, K., Takeuchi, K., Ohuchi, T and Okabe, S. Acid secretory and duodenal ulcerogenic responses induced by mepirizole in anesthetized rats. Dig. Dis. Sci. 39: 1625-1632, 1994.
31. Whittle, B.J.R/, Lopes-Bermonte, J. and Moncada, S. Regulation of gastric mucosal integrity by endogenous nitric oxide: Interaction with prostanoids and se sensory neuropeptides in the rat. Br. J. Pharmacol. 99: 607-611, 1990.
32. Whittle, B.J.R. and Lopez-Belmonte, J. Actions and interactions of endothelins, prostacyclin and nitric oxide in the gastric mucosa. J. Physiol. Pharmacol. 44: 91-107, 1993.
33. Yokotani, K., Okuma, Y. and Osumi, Y Inhibition of vagally mediated gastric acid secretion by activation of central prostanoid EP3 receptors in urethane-anesthetized rats. Br. J. Pharmacol. 117: 653-656, 1996.