Nitric oxide, prostaglandin, and sensory neurons in gastric mucosal blood flow response during acid secretion in rats

General Pharmacology

Volumn 28, Issue 4, 1997, Pages 513-519

  Kato, Shinichi ^a   Hirata, Takuya ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acid secretion; Gastric mucosal blood flow; Nitric oxide; Pentagastrin; Prostaglandin; Protection; Sensory neuron

Indexed keywords

ARGININE; GLYCINE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PENTAGASTRIN; PROSTAGLANDIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH ACID SECRETION; STOMACH MUCOSA;

ANIMALS; CAPSAICIN; CYCLOOXYGENASE INHIBITORS; ENZYME INHIBITORS; GASTRIC ACID; GASTRIC MUCOSA; H(+)-K(+)-EXCHANGING ATPASE; INDOMETHACIN; MALE; NEURONS, AFFERENT; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEPRAZOLE; PENTAGASTRIN; PROSTAGLANDINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030914646     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00350-3     Document Type: Article

References (29)

1. Gerber J. G. and Nies A. S. (1980) The role of prostaglandins in histamine-induced gastric vasodilation in the dog. J. Pharmacol. Exp. Ther. 213, 79-84.
2. Gerber J. G. and Guth P. H. (1989) Role of adenosine in the gastic mucosal blood flow response to pentagastrin in the rat. J. Pharmacol. Exp. Ther. 251, 550-556.
3. Gerkens J. F., Flexner C., Oates J. A. and Shand D. G. (1977) Prostaglandin and histamine involvement in the gastric vasodilator actions of pentagastrin. J. Pharmacol. Exp. Ther. 201, 421-426.
4. Holm-Rutili L. (1987) Effects of omeprazole on gastric mucosal microcirculation and acid secretion in the rat. Gastroentereology 92, 716-723.
5. Holm L. and Jagare A. (1992) Role of prostaglandins in regulation of gastric mucosal blood flow and acid secretion. Am. J. Physiol. 263, G446-G451.
6. Holzer P. and Guth P. H. (1991) Neuropeptide control of rat gastric mucosal blood flow: Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A. Circ. Res. 68, 100-105.
7. Holzer P., Livingston E. H. and Guth P. H. (1991) Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury. Gastroenterology 101, 416-424.
8. Holzer P., Lippe I. T., Jocic M., Wachter C., Erb R. and Heinemann A. (1993) Nitric oxide-dependent and independent hyperemia due to calcitonin gene-related peptides in the rat stomach. Br. J. Pharmacol. 110, 404-410.
9. +. Dig. Dis. Sci. 38, 1224-1232.
10. Kato S., Okabe S. and Takeuchi K. (1996) Pathways mediating pentagastrin-induced mucosal blood flow response in the rat stomachs. Dig. Dis. Sci. 41, 485-491.
11. Lippe I. T. and Holzer P. (1992) Participation of endothelium-derived nitric oxide but not prostacycline in the gastric mucosal hyperemia due to acid back-diffusion. Br. J. Pharmacol. 105, 708-714.
12. Livingston, E. H. and Holzer, P. (1993) Gastric hyperemia accompanying acid secretion is not mediated by sensory nerves. Dig. Dis. Sci. 38, 1190-1194.
13. Matsumoto J., Takeuchi K., Ueshima K. and Okabe S. (1992) Role of capsaicin-sensitive afferent neurons in mucosal blood flow response of rat stomach induced by mild irritants. Dig. Dis. Sci. 37, 1336-1344.
14. Mendez A., Casadevall M., Elizalde J. I., Del-Rivero M., Quintero E. and Pique J. M. (1996) Autoregulation of gastric mucosal blood flow takes place under certain circumstances. Gastroenterology 110, A346.
15. Nishizaki Y., Guth P. H., Kim G., Wayland H. and Kaunitz J. D. (1994) Pentagastrin enhances gastric mucosal defenses in vivo: Luminal acid-dependent and -independent effects. Am. J. Physiol. 267, G94-G104.
16. Perry M. A., Haedicke G. J., Bulkley G. B., Kivietys P. R. and Granger D. N. (1983) Relationship between acid secretion and blood flow in the canine stomach: Role of oxygen consumption. Gastroenterology 85, 529-534.
17. Pique J. M., Leung F. X., Tan H. W., Livingston E. H., Scremin O. U. and Guth P. H. (1988) Gastric mucosal blood flow response to stimulation and inhibition of gastric acid secretion. Gastroenterology 95, 642-650.
18. Pique J. M., Esplugues J. V. and Whittle B. J. R. (1991) Endogenous nitric oxide as mediator of gastric mucosal vasodilation during acid secretion. Gastroenterology 102, 168-174.
19. Salvemini D., Misko T. P., Masferrer J. L., Seibert K., Currie M. G. and Needleman P. (1993) Nitric oxide activates cyclooxygenase enzyme. Proc. Natl. Acad. Sci. USA 90, 7240-7244.
20. Stroff T., Plate S., Respondek M., Muller K. M. and Peskar B. M. (1995) Protection by gastrin in the rat stomach involves afferent neurons, calcitonin gene-related peptide, and nitric oxide. Gastroenterology 109, 89-97.
21. Svanes K., Varhang J. E., Holm P., Bakke A. and Romslo I. (1981) Effects of haemorrhagic shock on gastric mucosal blood flow and acid secretion in cats. Acta. Chir. Scand. 147, 81-88.
22. Takeuchi K., Ishihara Y., Okada M., Niida H. and Okabe S. (1988) A continuous monitoring of mucosal integrity and secretory activity in the rat stomach. Jpn. J. Pharmacol. 49, 235-244.
23. Takeuchi K., Niida H., Matsumoto J., Ueshima K. and Okabe S. (1991) Gastric motility changes in capsaicin-induced cytoprotection in the rat stomach. Jpn. J. Pharmacol. 55, 147-155.
24. Tepperman B. L. and Whittle B. J. R. (1992) Endogenous nitric oxide and sensory neuropeptides interact in the modulation of the rat gastric microcirculation. Br. J. Pharmacol. 105, 171-175.
25. Uchida S., Yano S. and Watanabe K. (1991) The role of capsaicin-sensitive afferent nerves in protective effect of capsaicin against absolute ethanol-induced gastric lesions in rats. Jpn. J. Pharmacol. 55, 279-282.
26. Walder C. E., Thiemermann C. and Vane J. R. (1990) Endothelium-derived relaxing factor participates in the increased blood flow in response to pentagastrin in the rat stomach mucosa. Proc. Roy. Soc. London. B. 241, 195-200.
27. Whittle B. J. R. (1983) The potentiation of taurocholate-induced rat gastric erosions following parenteral administration of cyclooxygenase inhibitor. Br. J. Pharmacol. 80, 545-551.
28. Whittle B. J. R., Lopez-Belmonte J. and Moncada S. (1990) Regulation of gastric mucosal integrity by endogenous nitric oxide: Interactions with prostanoids and sensory neuropeptides in the rat. Br. J. Pharmacol. 99, 607-611.
29. Whittle B. J. R., Lopez-Belmonte J. and Moncada S. (1992) Nitric oxide mediates rat mucosal vasodilation induced by intragastric capsaicin. Eur. J. Pharmacol. 218, 339-341.