Sequential mono-N-arylation of piperazine nitrogens. Part 2: The role of hydrogen bonding

Tetrahedron Letters

Volumn 40, Issue 31, 1999, Pages 5661-5665

  Eckert, Jeffrey ^a   Chan, Tze Ming ^a   Osterman, Rebecca M ^a   Lambert, Joseph B ^b   Gala, Dinesh ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; HYDROGEN; NITROGEN; OXIDIZING AGENT; PIPERAZINE DERIVATIVE; PROTON;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; ELECTRON; HYDROGEN BOND; MODEL; NUCLEAR MAGNETIC RESONANCE; PARTIAL DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

EID: 0033618313     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01104-1     Document Type: Article

References (11)

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9. 3 were heated in DMSO at 100-110°C for 18 hours. All yields are unoptimized, isolated, and based on the halobenzenes. Satisfactory analytical data were obtained for the products.
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11. These measurements were conducted on Varian XL-400 spectrometer using the inversion recovery method at 25°C.