Synthesis of 6-allyl and 6-heteroarylindoles by palladium catalyzed Stille cross-coupling reaction

Tetrahedron Letters

Volumn 40, Issue 31, 1999, Pages 5701-5703

  Benhida, Rachid ^a   Lecubin, Florence ^a   Fourrey, Jean Louis ^a   Castellanos, Lucrecia Rivas ^b   Quintero, Leticia ^b  

^a CNRS   (France)

^b Universidade de Puebla   (Mexico)

Author keywords

Heteroarylindoles; Palladium catalysts; Stille cross coupling

Indexed keywords

INDOLE DERIVATIVE; ORGANOTIN COMPOUND; PALLADIUM;

ARTICLE; CATALYSIS; CATALYST; CROSS LINKING; PARTIAL DRUG SYNTHESIS;

EID: 0033618297     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01094-1     Document Type: Article

References (5)

1. For a review see: Toyota, M.; Ihara, M. Nat. Prod. Rep. 1998, 15, 327-340.
2. Hegde, V. R.; Dai, P.; Patel, M.; Gullo, V. P. Tetrahedron Lett. 1998, 39, 5683-5684 and references cited therein.
3. Carbonnelle, A.-C.; Zamora, E. G.; Beugelmans, R.; Roussi, G. Tetrahedron Lett. 1998, 39, 4467-4470 and references cited therein.
4. Stille, J. K. Angew. Chem., Int. Ed. Engl. 1986, 25, 508-524.
5. 2 gave the same results with longer reaction time) in dry DMF (10 ml) was maintained under an inert atmosphere at the temperature as indicated. The mixture was diluted with EtOAc (50 ml) and filtered over Celite. After removal of the solvent, the residue was purified by flash chromatography (silica gel, EtOAc/heptane) to provide the 6-substituted indoles.