Morphological clues from multilegged frogs: Are retinoids to blame?

Science

Volumn 284, Issue 5415, 1999, Pages 800-802

  Sessions, Stanley K ^a   Franssen, R Adam ^a   Horner, Vanessa L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

RETINOID;

ARTICLE; FROG; IMAGE ANALYSIS; LIMB MALFORMATION; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; TREMATODE;

ANIMALS; ANURA; FORELIMB; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HINDLIMB; LIMB BUD; RANIDAE; TREMATODE INFECTIONS; TRETINOIN; UNITED STATES;

EID: 0033617533     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.284.5415.800     Document Type: Article

References (34)

1. L. Van Valen, J. Herpetol. 8, 109 (1974).
2. S. K. Sessions and S. B. Ruth, J. Exp. Zool. 254, 38 (1990).
3. M. Ouellet et al., J. Wildl. Dis. 33, 95 (1997).
4. J. R. Helgen, G. McKinnell, M. C. Gernes, in Status and Conservation of Midwestern Amphibians, M. J. Lanoo, Ed. (Univ. of Iowa Press, Iowa City, IA, 1998), pp. 288-297.
5. A. R. Blaustein et al., Proc. Natl. Acad. Sci. U.S.A. 94, 13735 (1997).
6. E. P. Volpe, Understanding evolution (Brown, Dubuque, IA, 1981).
7. V. French, P. J. Bryant, S. V. Bryant, Science 193, 969 (1976); S. V. Bryant, V. French, P. J. Bryant, ibid. 212, 993 (1981).
8. V. French, P. J. Bryant, S. V. Bryant, Science 193, 969 (1976); S. V. Bryant, V. French, P. J. Bryant, ibid. 212, 993 (1981).
9. The developmental consequences of both mechanical perturbation and retinoid treatment in developing and regenerating amphibian limbs may involve the same fundamental cellular mechanism (9).
10. S. V. Bryant and D. M. Gardiner, Dev. Biol. 152, 1 (1992).
11. S. R. Scadding and M. Maden, J. Embryol. Exp. Morphol. 91, 19 (1986); ibid., p. 35.
12. S. R. Scadding and M. Maden, J. Embryol. Exp. Morphol. 91, 19 (1986); ibid., p. 35.
13. M. Maden, Dev. Biol. 98, 409 (1983).
14. _, J. Embryol. Exp. Morphol. 63, 243 (1981).
15. M. A. Harmon et al., Proc. Natl. Acad. Sci. U.S.A. 92, 6157 (1995).
16. Certain other abnormalities have been described in RA-treated regenerating limbs of amphibians but only PD duplications are a unique, diagnostic effect of RA on regenerating limbs (9-11).
17. R. D. Riddle et al., Cell 75, 1401 (1993).
18. D. M. Gardiner et al., Development 121, 1731 (1995).
19. D. M. Gardiner and S. V. Bryant, Int. J. Dev. Biol. 40, 797 (1996).
20. M. Maden, Dev. Biol. 159, 379 (1993).
21. S. D. Thoms and D. L. Stocum, ibid. 103, 319 (1984); W-S. Kim and D. L. Stocum, ibid. 114, 170 (1986); S. K. Sessions, N. Wanek, S. V. Bryant, Am. Zool. 29, 73A (1989); D. C. Ludolph, J. A. Cameron, D. L. Stocum. Dev. Biol. 140, 41 (1990).
22. S. D. Thoms and D. L. Stocum, ibid. 103, 319 (1984); W-S. Kim and D. L. Stocum, ibid. 114, 170 (1986); S. K. Sessions, N. Wanek, S. V. Bryant, Am. Zool. 29, 73A (1989); D. C. Ludolph, J. A. Cameron, D. L. Stocum. Dev. Biol. 140, 41 (1990).
23. S. D. Thoms and D. L. Stocum, ibid. 103, 319 (1984); W-S. Kim and D. L. Stocum, ibid. 114, 170 (1986); S. K. Sessions, N. Wanek, S. V. Bryant, Am. Zool. 29, 73A (1989); D. C. Ludolph, J. A. Cameron, D. L. Stocum. Dev. Biol. 140, 41 (1990).
24. S. D. Thoms and D. L. Stocum, ibid. 103, 319 (1984); W-S. Kim and D. L. Stocum, ibid. 114, 170 (1986); S. K. Sessions, N. Wanek, S. V. Bryant, Am. Zool. 29, 73A (1989); D. C. Ludolph, J. A. Cameron, D. L. Stocum. Dev. Biol. 140, 41 (1990).
25. D. L. Stocum, Cell 67, 5 (1991).
26. R. G. Harrison, Organization and Development of the Embryo (Yale Univ. Press, New Haven, CT, 1969); S. V. Bryant, D. M. Gardiner, K. Muneoka, Am. Zool. 27, 675 (1987).
27. R. G. Harrison, Organization and Development of the Embryo (Yale Univ. Press, New Haven, CT, 1969); S. V. Bryant, D. M. Gardiner, K. Muneoka, Am. Zool. 27, 675 (1987).
28. L. S. Honig and D. S. Summerbell, J. Embryol. Exp. Morphol. 87, 163 (1985); D. M. Gardiner and S. V. Bryant, J. Exp. Zool. 251, 47 (1989).
29. L. S. Honig and D. S. Summerbell, J. Embryol. Exp. Morphol. 87, 163 (1985); D. M. Gardiner and S. V. Bryant, J. Exp. Zool. 251, 47 (1989).
30. We have identified the trematode as a species of the psilostomid genus Ribeiroia.
31. P. T. Johnson, thesis (Stanford University, 1998).
32. P. T. J. Johnson et al., Science 284, 802 (1999); S. K. Sessions et al., unpublished data.
33. P. T. J. Johnson et al., Science 284, 802 (1999); S. K. Sessions et al., unpublished data.
34. Supported by Trustee Grants from Hartwick College, a grant from the Oregon Community Foundation, and a donation from Mr. and Mrs. Carleton Stewart. We thank A. Blaustein, M. Kuhlmann, and D. Wake for helpful comments and suggestions, A. Blaustein, J. Bowerman, R. Fitzmorris, D. Maddison, S. Ruth, M. Sredl (Arizona Game and Fish), P. Warny, and S. Wray (Oregon Fish and Game) provided specimens. P. Johnson shared results with us.