Effects of ischemia on discontinuous action potential conduction in hybrid pairs of ventricular cells

Circulation

Volumn 99, Issue 12, 1999, Pages 1623-1629

  Wilders, Ronald ^a,b   Verheijck, E Etienne ^a,b   Joyner, Ronald W ^c   Golod, David A ^c   Kumar, Rajiv ^c   Van Ginneken, Antoni C G ^b   Bouman, Lennart N ^b   Jongsma, Habo J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c EMORY UNIVERSITY   (United States)

Author keywords

Arrhythmia; Catecholamines; Conduction; Ischemia

Indexed keywords

ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CATECHOLAMINE RELEASE; GUINEA PIG; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART VENTRICLE; HYBRID CELL; ION CONDUCTANCE; ION CURRENT; NONHUMAN; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; REENTRY ARRHYTHMIA;

EID: 0033616924     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.12.1623     Document Type: Article

References (19)

1. Myerburg RJ, Kessler KM, Castellanos A. Interactions between structure and function in sudden cardiac death. In: Akhtar M, Myerburg RJ, Ruskin JN, eds. Sudden Cardiac Death. Philadelphia, Pa: Williams & Wilkins; 1994:32-47.
2. de Bakker JMT, van Capelle FJL, Janse MJ, Tasseron S, Vermeulen JT, de Jonge N, Lahpor JR. Slow conduction in the infarcted human heart: "zigzag" course of activation. Circulation. 1993;88:915-926.
3. Gardner PI, Ursell PC, Fenoglio JJ, Wit AL. Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts. Circulation. 1985;72:596-611.
4. Kienzle MG, Tan RC, Ramza BM, Young ML, Joyner RW. Alterations in endocardial activation of the canine papillary muscle early and late after myocardial infarction. Circulation. 1987;76:860-874.
5. Schömig A, Richardt G. Cardiac sympathetic activity in myocardial ischemia: release and effects of noradrenaline. Basic Res Cardiol. 1990; 85(suppl 1):9-30.
6. Podrid PJ, Fuchs T, Candinas R. Role of the sympathetic nervous system in the genesis of ventricular arrhythmia. Circulation. 1990;82(suppl I):I-103-I-113.
7. Sugiura H, Joyner RW. Action potential conduction between guinea pig ventricular cells can be modulated by calcium current. Am J Physiol. 1992;263:H1591-H1604.
8. Joyner RW, Kumar R, Wilders R, Jongsma HJ, Verheijck EE, Golod DA, Van Ginneken ACG, Wagner MB, Goolsby WN. Modulating L-type calcium current affects discontinuous cardiac action potential conduction. Biophys J. 1996;71:237-245.
9. Rohr S, Kucera JP. Involvement of the calcium inward current in cardiac impulse propagation: induction of unidirectional conduction block by nifedipine and reversal by Bay K 8644. Biophys J. 1997;72:754-766.
10. Shaw RM, Rudy Y. Ionic mechanisms of propagation in cardiac tissue: roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res. 1997;81: 727-741.
11. Cordeiro JM, Howlett SE, Ferrier GR. Simulated ischemia and reperfusion in isolated guinea pig ventricular myocytes. Cardiovasc Res. 1994;28:1794-1802.
12. Wilders R, Kumar R, Joyner RW, Jongsma HJ, Verheijck EE, Golod DA, Van Ginneken ACG, Goolsby WN. Action potential conduction between a ventricular cell model and an isolated ventricular cell. Biophys J. 1996;70:281-295.
13. Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential, I: simulations of ionic currents and concentration changes. Circ Res. 1994;74:1071-1096.
14. + current through K-ATP channels in isolated heart cells of the guinea-pig. J Physiol (Lond). 1992;454:339-357.
15. Varro A, Lathrop DA, Hester SB, Nanasi PP, Papp JG. Ionic currents and action potentials in rabbit, rat, and guinea pig ventricular myocytes. Basic Res Cardiol. 1993;88:93-102.
16. Sakmann B, Trube G. Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart. J Physiol (Lond). 1984;347:641-657.
17. max and the transient outward current. Circulation. 1992;85:1175-1188.
18. Boyden PA, Pinto JM. Reduced calcium currents in subendocardial Purkinje myocytes that survive in the 24-and 48-hour infarcted heart. Circulation. 1994;89:2747-2759.
19. Spach MS, Heidlage JF. The stochastic nature of cardiac propagation at a microscopic level: electrical description of myocardial architecture and its application to conduction. Circ Res. 1995;76:366-380.