The impact of molecular biology on neuroscience

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 354, Issue 1392, 1999, Pages 2021-2025

  Crick, Francis ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Conditional knockouts; Neuronal cell types; New tools; The recording problem

Indexed keywords

ANIMALIA;

EID: 0033616137     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.1999.0541     Document Type: Article

References (16)

1. Baron, U., Schnappinger, D., Helbl. V, Gossen, M. & Hillen, W. 1999 Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proc. Natl Acad. Sci. USA 96, 1013-1018.
2. Cajal, S. R. Y. 1995 Histology of the nervous system, of man and invertebrates. Oxford University Press. (Translated by N. Swanson & L. W. Swanson.)
3. Crick, F. 1988 What mad pursuit. London: Penguin Books.
4. de Lima, A. D., Voigt, T. & Morrison, J. H. 1990 Morphology of the cells within the inferior temporal gyrus that project to the prefrontal cortex in the macaque monkey. J. Comp. Neurol. 296, 159-172.
5. Furth, P. A., St Onge, L., Boger, H., Gruss, P., Gossen, M, Kistner, A., Bujard, H. & Henninghausen, L. 1994 Temporal control of gene expression in transgenic mice by tetracycline-responsive promoter. Proc. Natl Acad. Sci. USA 91, 9302-9306.
6. Hoover, J. E. & Strick, P. L. 1999 The organization of cerebellar and basal ganglia outputs to primary motor cortex as revealed by retrograde transneuronal transport of herpes simplex virus type 1. J. Neurosci. 19, 1446-1463.
7. Izquierdo I. & Medina, J. H. 1998 On brain lesions, the milkman and Sigmunda. Trends Neurosci. 21, 423-426.
8. Jacob, F. 1977 Evolution and tinkering. Science 196, 1161-1166.
9. Johns, D. C., Marx, R., Mains, R. E., O'Rourke, B. & Marbán, E. 1999 Inducible genetic suppression of neuronal excitability. J. Neurosci. 19, 1691-1697.
10. Miesenböck, G., De Angelis, D. A. & Rothman, J. E. 1998 Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature 394, 192-195.
11. Nirenberg, S. & Cepko, C. 1993 Targeted ablation of diverse cell classes in the nervous system in vivo. J. Neurosci. 13, 3238-3251.
12. No, D.,Yao,T.-P. & Evans, R. M. 1996 Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl Acad. Sci. USA 93, 3346-3351.
13. Payne, B. R., Lomber S. G., Villa A. E. & Bullier J. 1996 Reversible deactivation of cerebral network components. Trends Neurosci. 19, 535-542.
14. Shockett, P., Difilippantonio, M., Hellman, N. & Schatz, D. G. 1995 A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc. Natl Acad. Sci. USA 92, 6522-6526.
15. Wilson M. A. & Tonegawa S. 1997 Synaptic plasticity, place cells and spatial memory: study with second generation knockouts. Trends Neurosci. 20, 102-106.
16. Yoshihara, Y. (and 13 others) 1999 A genetic approach to visualization of multisynaptic neural pathways using plant lectin transgene. Neuron 22, 33-41.