β-Amino acid facilitates macrocyclic ring closure in a combinatorial library

Tetrahedron Letters

Volumn 40, Issue 44, 1999, Pages 7757-7760

  Jefferson, Elizabeth A ^a   Swayze, Eric E ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOALCOHOL; BETA AMINO ACID; MACROCYCLIC COMPOUND; PEPTIDE LIBRARY; RESIN;

ARTICLE; CYCLIZATION; PARTIAL DRUG SYNTHESIS; SOLID STATE;

EID: 0033615793     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01658-5     Document Type: Article

References (24)

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20. + calcd 351.1305, obsd 351.1300.
21. 9. Fmoc β-amino acids can be obtained from the commerically available Fmoc-α-amino acids via the Erndt-Eistert reaction (Guichard, G.; Abele, S.; Seebach, D. Helvetica Chimica Acta 1998, 81, 187-206).
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24. 6) 8.71 (s, 1 H), 8.52 (d, 1 H, J=6.0 Hz), 8.38 (d, 1H, J=9.2 Hz), 8.23-8.31 (m, 3 H), 7.86 (d, 1H, J=6 Hz), 7.53 (d, 1 H, J=9.6 Hz), 4.40-4.45 (m, 1H), 4.35-4.31 (m, 1H), 4.09-4.12 (m, 2H), 3.98 (m, 1 H), 3.90-3.94 (m, 2 H), 1.43-1.67 (m, 3 H), 1.18 (d, J=6.8 Hz), 8.75 (dd, 6 H).