An expeditious route to novel 1,4,2-benzodiazaphosphepin-5-one 2-oxide analogues

Journal of Organic Chemistry

Volumn 64, Issue 22, 1999, Pages 8156-8160

  Karp, Gary M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE;

ALKYLATION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION; DRUG SYNTHESIS;

EID: 0033615626     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9908400     Document Type: Article

References (38)

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36. No effort has been made to determine the equilibrium position between the sodium salt of the phosphonamidate + EtOH ↔ phosphonamidate + NaOEt.
37. The author would like to thank one of the reviewers for comments concerning the role that additional NaH plays in the tandem cyclization/alkylation of 6b. Additional experiments indicated that 9 is obtained as the sole product in instances where NaH is kept near stoichiometric so as to avoid the formation of sodium ethoxide.
38. The 1,4,2-benzodiazaphosphepin-5-one 2-oxides and thioxides reported herein were evaluated for their herbicidal activity both in the whole plant and in vitro and were found to be much less active than the isosteric 1,4-benzodiazepine-2,5-diones.