Voltage-dependency of the dopamine transporter in the rat substantia nigra

Neuroscience Letters

Volumn 260, Issue 2, 1999, Pages 105-108

  Hoffman, Alexander F ^a   Zahniser, Nancy R ^a   Lupica, Carl R ^a   Gerhardt, Greg A ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Baclofen; Brain slice; Dopamine transporter; In vivo electrochemistry; Substantia nigra; Whole cell patch clamp

Indexed keywords

BACLOFEN; DOPAMINE TRANSPORTER;

ANIMAL EXPERIMENT; ARTICLE; DOPAMINE UPTAKE; DOPAMINERGIC TRANSMISSION; HYPERPOLARIZATION; MALE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

ANIMALS; BACLOFEN; CARRIER PROTEINS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ELECTROCHEMISTRY; ELECTROPHYSIOLOGY; GABA AGONISTS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA;

EID: 0033613782     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00951-3     Document Type: Article

References (19)

1. Amara S.G., Kuhar M.J. Neurotransmitter transporters: recent progress. Annu. Rev. Neurosci. 16:1993;73-93.
2. Cass W.A., Gerhardt G.A. Direct in vivo evidence that D2 dopamine receptors can modulate dopamine uptake. Neurosci. Lett. 176:1994;259-263.
3. Dickinson S.D., Sabeti J., Larson G.A., Giardina K., Rubinstein M., Kelly M.A., Grandy D.K., Low M.J., Gerhardt G.A., Zahniser N.R. Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in the dorsal striatum. J. Neurochem. 72:1999;148-156.
4. Galli A., Petersen C.I., Deblaquiere M., Blakely R.D., DeFelice L.J. Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. J. Neurosci. 17:1997;3401-3411.
5. Hebert M.A., van Horne C.G., Hoffer B.J., Gerhardt G.A. Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis. J. Pharmacol. Exp. Ther. 279:1996;1181-1190.
6. Hoffman A.F., Gerhardt G.A. In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions. J. Neurochem. 70:1998;179-189.
7. Hoffman A.F., Lupica C.R., Gerhardt G.A. Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices. J. Pharmacol. Exp. Ther. 287:1998;487-496.
8. Kim K.M., Nakajima S., Nakajima Y. Dopamine and GABA receptors in cultured substantia nigra neurons: correlation of electrophysiology and immunocytochemistry. Neuroscience. 78:1997;759-769.
9. Krueger B.K. Kinetics and block of dopamine uptake in synaptosomes from rat caudate nucleus. J. Neurochem. 55:1990;260-267.
10. Lacey M.G., Mercuri N.B., North R.A. Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta. J. Physiol. 392:1987;397-416.
11. B and dopamine D2 receptors in rat substantia nigra neurones. J. Physiol. 401:1988;437-453.
12. Lacey M.G., Mercuri N.B., North R.A. Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids. J. Neurosci. 9:1989;1233-1241.
13. Lester H.A., Cao Y.W., Mager S. Listening to neurotransmitter reporters. Neuron. 17:1996;807-810.
14. Lupica C.R. Delta and mu enkephalins inhibit spontaneous GABA-mediated IPSCs via a cyclic AMP-independent mechanism in the rat hippocampus. J. Neurosci. 15:1995;737-749.
15. Meiergerd S.M., Patterson T.A., Schenk J.O. D2 receptors may modulate the function of the striatal transporter for dopamine: kinetic evidence from studies in vitro and in vivo. J. Neurochem. 61:1993;764-767.
16. Nirenberg M.J., Vaughan R.A., Uhl G.R., Kuhar M.J., Pickel V.M. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. J. Neurosci. 16:1996;436-447.
17. Reith M.E.A., Xu C., Chen N.H. Pharmacology and regulation of the neuronal dopamine transporter. Eur. J. Pharmacol. 324:1997;1-10.
18. Sonders M.S., Amara S.G. Channels in transporters, Curr. Opin. Neurobiol. 6:1996;294-302.
19. Sonders M.S., Zhu S.J., Zahniser N.R., Kavanaugh M.P., Amara S.G. Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants. J. Neurosci. 17:1997;960-974.