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22
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0013556250
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2 to amide (S,R)-16 provided low de (<2%) of 6 Therefore, conformationally locked acetonide ketoamide (S,R)-2a was considered (see reference 9b)
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2 to amide (S,R)-16 provided low de (<2%) of 6 Therefore, conformationally locked acetonide ketoamide (S,R)-2a was considered (see reference 9b).
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23
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0000035304
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(b) Askin, D.; Wallace, J. P.; Vacca, J. P.; Reamer, R. A.; Volante, R. P.; Shinkai, I. J. Org. Chem. 1992, 57, 2771.
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Shinkai, I.6
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24
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0013557963
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Cyclohexyl keto acid was prepared by reacting cyclohexyl MgBr with diethyl oxalate to give 80-87% yield of ethyl cyclohexyl keto ester followed by basic hydrolysis. See reference: Weinstock, L. M.; Currie, R. B.; Lovell, A. V. Syn. Comm. 1981, 943.
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0013560645
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4 reduction of (S,R)-2a. Recently Corey reported that isopropyl MgBr instead of addition to carbonyl group reduction was observed. See Corey, E. J.; Li, W.; Nagamitsu. Angew. Chem. Int. Ed. Engl. 1998, 37, 1677.
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Corey, E.J.1
Li, W.2
Nagamitsu3
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26
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0013489531
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THF was the solvent of choice. For example, toluene and dioxane provided 60:40 dr and 80:20 dr respectively
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(b) THF was the solvent of choice. For example, toluene and dioxane provided 60:40 dr and 80:20 dr respectively.
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27
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0031005924
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(a) Zheng, N.; Armstrong, J. D.; McWilliams, C.; Volante, R.P. Tetrahedron Lett. 1997, 38, 2817.
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Zheng, N.1
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0030909045
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(b) Kress, H. M.; Yang, C.; Yasuda, N.; Grabowski, E. J. J. Tetrahedron Lett. 1997, 38, 2633.
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Kress, H.M.1
Yang, C.2
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Grabowski, E.J.J.4
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29
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0013551050
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13b and enantiomeric excesses were determined by Chiralpak AS
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13b and enantiomeric excesses were determined by Chiralpak AS.
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