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Volumn 40, Issue 5, 1999, Pages 819-822

Rigid aminoalcohol backbone as a highly defined chiral template for the preparation of optically active tertiary α-hydroxyl acids

Author keywords

[No Author keywords available]

Indexed keywords

OXYBUTYNIN;

EID: 0033613779     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02587-8     Document Type: Article
Times cited : (73)

References (32)
  • 22
    • 0013556250 scopus 로고    scopus 로고
    • 2 to amide (S,R)-16 provided low de (<2%) of 6 Therefore, conformationally locked acetonide ketoamide (S,R)-2a was considered (see reference 9b)
    • 2 to amide (S,R)-16 provided low de (<2%) of 6 Therefore, conformationally locked acetonide ketoamide (S,R)-2a was considered (see reference 9b).
  • 24
    • 0013557963 scopus 로고
    • Cyclohexyl keto acid was prepared by reacting cyclohexyl MgBr with diethyl oxalate to give 80-87% yield of ethyl cyclohexyl keto ester followed by basic hydrolysis. See reference: Weinstock, L. M.; Currie, R. B.; Lovell, A. V. Syn. Comm. 1981, 943.
    • (1981) Syn. Comm. , pp. 943
    • Weinstock, L.M.1    Currie, R.B.2    Lovell, A.V.3
  • 25
    • 0013560645 scopus 로고    scopus 로고
    • 4 reduction of (S,R)-2a. Recently Corey reported that isopropyl MgBr instead of addition to carbonyl group reduction was observed. See Corey, E. J.; Li, W.; Nagamitsu. Angew. Chem. Int. Ed. Engl. 1998, 37, 1677.
    • (1998) Angew. Chem. Int. Ed. Engl. , vol.37 , pp. 1677
    • Corey, E.J.1    Li, W.2    Nagamitsu3
  • 26
    • 0013489531 scopus 로고    scopus 로고
    • THF was the solvent of choice. For example, toluene and dioxane provided 60:40 dr and 80:20 dr respectively
    • (b) THF was the solvent of choice. For example, toluene and dioxane provided 60:40 dr and 80:20 dr respectively.
  • 29
    • 0013551050 scopus 로고    scopus 로고
    • 13b and enantiomeric excesses were determined by Chiralpak AS
    • 13b and enantiomeric excesses were determined by Chiralpak AS.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.