Search for a Caenorhabditis elegans FMR1 homologue: Identification of a new putative RNA-binding protein (PRP-1) that hybridizes to the mouse FMR1 double K homology domain

American Journal of Medical Genetics

Volumn 84, Issue 3, 1999, Pages 283-285

  Shtang, Sharon ^a   Perry, Marc D ^a   Percy, Maire E ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b Neurogenetics Laboratory   (Canada)

Author keywords

C. elegans; FMR1 homologue; FMR1 protein; Fragile X syndrome; KH domains; RNA binding protein

Indexed keywords

HYBRID PROTEIN; POLYGLUTAMIC ACID; PROLINE; RNA BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; DNA HYBRIDIZATION; DNA LIBRARY; DNA PROBE; FRAGILE X SYNDROME; GENETIC LINKAGE; GENETIC SCREENING; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CHROMOSOME MAPPING; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PEPTIDES; RNA-BINDING PROTEINS;

EID: 0033612338     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19990528)84:3<283::AID-AJMG23>3.0.CO;2-3     Document Type: Article

References (15)

1. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. 1990. Basic local alignment search tool. J Mol Biol 215:403-410.
2. Ashley CT, Sutcliffe JS, Kunst CB, Leiner HA, Eichler EE, Nelson DL, Warren ST. 1993a. Human and murine FMR1: alternative splicing and translational initiation down-stream of the CGG-repeat. Nat Genet 4:244-251.
3. Ashley CT Jr, Wilkinson KD, Reines D, Warren ST. 1993b. FMR1 protein: conserved RNP family domains and selective RNA binding. Science 262:563-566.
4. Conrad R, Lea K, Blumenthal T. 1995. SL1 trans-splicing specified by AU-rich synthetic RNA inserted at the 5′ end of Caenorhabditis elegans pre-mRNA. RNA 1:164-170.
5. + mRNA in actively translating polyribosomes. Hum Mol Genet 6:1465-1472.
6. Currie JR, Brown WT. 1999. KH-domain-containing proteins of yeast: absence of a fragile X gene homologue. Am J Med Genet (in press).
7. Higgins DG, Thompson JD, Gibson TJ. 1996. Using CLUSTAL for multiple sequence alignments. Methods Enzymol 266:383-402.
8. Kenyon C. 1988. The nematode Caenorhabditis elegans. Science 240:1448-1453.
9. Khandjian EW, Corbin F, Woerly S, Rousseau F. 1996. The fragile X mental retardation gene is associated with ribosomes. Nat Genet 12:91-93.
10. Price DK, Zhang F, Ashley CT Jr, Warren ST. 1996. The chicken FMR1 gene is highly conserved with a CTT 5′-untranslated repeat and encodes an RNA-binding protein. Genomics 31:3-12.
11. Sambrook J, Fritsch EF, Maniatis T. 1989. In: Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
12. Siomi H, Choi M, Siomi MC, Nussbaum RL, Dreyfuss G. 1994. Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome. Cell 77:33-39.
13. Siomi H, Siomi MC, Nussbaum RL, Dreyfuss G. 1993. The protein product of the fragile X gene, FMR1, has characteristics of an RNA binding protein. Cell 74:291-298.
14. Siomi MC, Siomi H, Sauer WH, Srinivasan S, Nussbaum RL, Dreyfuss G. 1995. FXR1, an autosomal homology of the fragile X mental retardation gene. EMBO J 14:2401-2408.
15. Zhang Y, O'Connor JP, Siomi MC, Srinivasan S, Dutra A, Nussbaum RL, Dreyfuss G. 1995. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. EMBO J 14:5358-5366.