Both the rate and spectrum of loss of heterozygosity differ between human lymphoblastoid cells derived from various donors

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 423, Issue 1-2, 1999, Pages 1-10

  De Nooij van Dalen, Arnolda G ^a   Giphart, Marius J ^b   Lohman, Paul H M ^a   Giphart Gassler, Micheline ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Chromosome loss; HLA; LOH; Microsatellite; Recombination

Indexed keywords

HLA ANTIGEN;

ALLELE; ARTICLE; CELL LINE; CELL TRANSFORMATION; CHROMOSOME 6; CHROMOSOME LOSS; CONTROLLED STUDY; GENE DELETION; GENE DUPLICATION; GENE INACTIVATION; GENE MUTATION; GENETIC RECOMBINATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; PHENOTYPE; POLYPLOIDY; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

AGED; AGED, 80 AND OVER; CELL LINE, TRANSFORMED; CELLS, CULTURED; CHROMOSOME DELETION; CLONE CELLS; DNA; HLA-A2 ANTIGEN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LOSS OF HETEROZYGOSITY; LYMPHOCYTES;

EID: 0033601848     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00204-8     Document Type: Article

References (35)

1. A.G. Knudson Jr., Genetics of human cancer, Annu. Rev. Genet. 20 (1986) 231-251.
2. A.G. Knudson, Antioncogenes and human cancer, Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 10914-10921.
3. E.J. Stanbridge, Human tumor suppressor genes, Annu. Rev. Genet. 24 (1990) 615-657.
4. W. Cavenee, T.P. Dryja, R.A. Philips, W.F. Benedict, R. Godbout, B.L. Gallie, A.L. Murphree, L.C. Strong, R.L. White, Expression of recessive alleles by chromosomal mechanisms in retinoblastoma, Nature 305 (1983) 784-799.
5. A.G. de Nooij-van Dalen, V.H.A. van Buuren-van Seggelen, P.H.M. Lohman, M. Giphart-Gassler, Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro, Genes, Chromosomes and Cancer 21 (1998) 98-102.
6. D.W. Yandell, T.P. Dryja, J.B. Little, Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells, Mutat. Res. 229 (1990) 98-102.
7. D.K. Klinedinst, N.R. Drinkwater, Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells, Mutat. Res. 250 (1991) 365-374.
8. C.Y. Li, D.W. Yandell, J.B. Little, Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro, Somatic Cell Mol. Genet. 18 (1992) 77-87.
9. E.G. Lichtenauer-Kaligis, I. van der Velde-van Dijke, H. den Dulk, P. van de Putte, M. Giphart-Gassler, J.G. Tasseron-de Jong, Genomic position influences spontaneous mutagenesis of an integrated retroviral vector containing the hprt cDNA as target for mutagenesis, Hum. Mol. Genet. 2 (1993) 173-182.
10. L.E. Smith, A.J. Grosovsky, Genetic instability on chromosome 16 in a human B lymphoblastoid cell line, Somatic Cell Mol. Genet. 19 (1993) 515-527.
11. S.L. Nelson, C.R. Giver, A.J. Grosovsky, Spectrum of X-ray induced mutations in the human hprt gene, Carcinogenesis 15 (1994) 119-122.
12. A.G. de Nooij-van Dalen, V.H.A. van Buuren-van Seggelen, A. Mulder, K. Gelsthorpe, J. Cole, P.H.M. Lohman, M. Giphart-Gassler, Isolation and molecular characterization of spontaneous mutants of lymphoblastoid cells with extended loss of heterozygosity, Mutat. Res. 374 (1997) 51-62.
13. A.A. Morley, S.A. Grist, D.R. Turner, A. Kutlaca, G. Bennett, Molecular nature of in vivo mutations in human cells at the autosomal HLA-A locus, Cancer Res. 50 (1990) 4584-4587.
14. S.E. Luria, M. Delbruck, Mutations of bacteria from virus sensitivity to virus resistence, Genetics 28 (1943) 491-511.
15. R.L. Capizzi, J.W. Jameson, A table for the estimation of the spontaneous mutation rate of cells in culture, Mutat. Res. 17 (1973) 147-148.
16. L.J. Kennedy, S.G.E. Marsh, J. Bodmer, Cytotoxic monoclonal antibodies, in: B. Dupont, Immunobiology of HLA, Springer-Verlag, New-York, 1987, pp 301-305.
17. J. Bodmer. J.H. Moses. S.G.E. Marsh. Report on the monoclonal antibodies used in the Seventh International Histocompatibility Workshop, Vol. 1, 1992, pp. 264-279.
18. C. Dib, S. Faure, C. Fizames, D. Samson, N. Drouot, A. Vignal, P. Millasseau, S. Marc, J. Hazan, E. Seboun, M. Lathrop, G. Gyapay, J. Morissette, J. Weissenbach, A comprehensive genetic map of the human genome based on 5,264 microsatellites, Nature 380 (1996) 152-154.
19. V.C. Sheffield, J.L. Weber, K.H. Buetow, J.C. Murray, D.A. Even, K. Wiles, J.M. Gastier, J.C. Pulido, C. Yandava, S.L. Sunden et al., A collection of tri- and tetranucleotide repeat markers used to generate high quality, high resolution human genome-wide linkage maps, Hum. Mol. Genet. 4 (1995) 1837-1844.
20. M.H. Polymeropoulos, D.S. Rath, H. Xiao, C.R. Merril, Tetranucleotide repeat polymorphism at the human coagulation factor XIII A subunit gene (F13A1), Nucleic Acids Res. 19 (1991) 4306.
21. E.T. Hojo, P.C. van Diemen, F. Darroudi, A.T. Natarajan, Spontaneous chromosomal aberrations in Fanconi anaemia, ataxia telangiectasia fibroblast and Bloom's syndrome lymphoblastoid cell lines as detected by conventional cytogenetic analysis and fluorescence in situ hybridisation (FISH) technique, Mutat. Res. 334 (1995) 59-69.
22. E.C. Jazwinska, W.R. Pyper, M.J. Burt, J.L. Francis, S. Goldwurm, S.I. Webb, S.C. Lee, J.W. Halliday, L.W. Powell, Haplotype analysis in australian hemochromatosis patients: evidence for a predominant ancestral haplotype exclusively associated with hemochromatosis, Am. J. Hum. Genet. 56 (1995) 428-433.
23. H.L. Liber, D.W. Yandell, J.B. Little, A comparison of mutation induction at the tk and hprt loci in human lymphoblastoid cells; quantitative differences are due to an additional class of mutations at the autosomal tk locus, Mutat. Res. 216 (1989) 9-17.
24. S.A. Amundson, F. Xia, K. Wolfson, H.L. Liber, Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor, Mutat. Res. 286 (1993) 233-241.
25. S. Taketani, M.S. Krangel, D. Pious, J.L. Strominger, Structural analysis of HLA-A2 antigen from immunoselected mutant 8.6.1: further definition of an HLA-A2-specific serological determinant, J. Immunol. 131 (1983) 2935-2938.
26. C. Layet, B. Kahn Perles, P. Pontarotti, P. Ferrier, J. Sire, F.A. Lemonnier, Creation of an HLA-A2 / HLA-Aw69 alloantigenic determinant on an HLA-A3 molecule by site-directed mutagenesis, J. Immunol. 138 (1987) 2197-2201.
27. R.D. Salter, C. Clayberger, C.E. Lomen, A.M. Krensky, P. Parham, In vitro mutagenesis at a single residue introduces B and T cell epitopes into a class I HLA molecule, J. Exp. Med. 166 (1987) 283-288.
28. K.T. Hogan, S.L. Brown, Localization and characterization of serologic epitopes on HLA-A2, Hum. Immunol. 33 (1992) 185-192.
29. F. Xia, S.A. Amundson, J.A. Nickoloff, H.L. Liber, Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation, Mol. Cell. Biol. 14 (1994) 5850-5857.
30. F. Xia, X. Wang, Y.-H. Wang, N. Tsang, D.W. Yandell, K.T. Kelsey, H.L. Liber, Altered p53 status correlates with differences in sensitivity to radiation-induced mutation in two closely related human lymphoblastoid cell lines, Cancer Res. 55 (1995) 231-239.
31. F. Xia, H.L. Liber, The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line, Mutat. Res. 373 (1997) 87-97.
32. D.R. Turner, S.A. Grist, M. Janatipour, A.A. Morley, Mutations in human lymphocytes commonly involve gene duplication and resemble those seen in cancer cells, Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 3189-3192.
33. R.H. Lekanne-Deprez, N.A. Groen, D. Louz, A. Hagemeijer, E. Van Drunen, J.W. Koper, C.J. Avezaat, D. Bootsma, T.H. van der Kwast, E.C. Zwarthoff, Constitutional DNA-level aberrations in chromosome 22 in a patient with multiple mengiomas, Genes, Chromosome and Cancer 9 (1994) 124-128.
34. B. Pederson, J. Koch, K.B. Hansen, J. Hindkjaer, C. Lindbjerg Andersen, The monosomy 7 clone in interphase and metaphase cell population: a combined chromosome and primed in situ labeling study, Acta Heamatol. 97 (1997) 216-221.
35. K. Han, E.J. Oh, Y.S. Kim, Y.G. Kim, K.Y. Lee, C.S. Kang, B.K. Kim, W.I. Kim, S.I. Shim, S.M. Kim, Chromosomal numerical aberrations in gastric carcinoma: analysis of eighteen cases using in situ hybridization, Cancer Genet. Cytogenet. 92 (1996) 122-129.