A novel, thioacetal based linker for solid-phase synthesis

Tetrahedron Letters

Volumn 40, Issue 4, 1999, Pages 683-686

  Huwe, Christoph M ^a   Künzer, Hermann ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Combinatorial chemistry; Solid phase synthesis; Thioacetals

Indexed keywords

4 ACETYLBIPHENYL DERIVATIVE; [BIS(TRIFLUOROACETOXY)IODO]BENZENE; THIOACETAL DERIVATIVE; THIOCTIC ACID; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; BINDING AFFINITY; CHEMICAL REACTION KINETICS; DRUG MANUFACTURE; IMMOBILIZATION; ORGANIC CHEMISTRY; REACTION ANALYSIS; SOLID PHASE EXTRACTION; SYNTHESIS;

LATEOLABRAX JAPONICUS;

EID: 0033593298     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02580-5     Document Type: Article

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28. -1.
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33. 3): δ/ppm = 26.8, 35.6, 68.9, 114.2, 126.7, 128.6, 129.0, 130.4, 130.6, 137.8, 162.7, 196.8; HR-MS (EI): calcd 240.1150, found 240.1147.
34. Overall yield for the steps immobilization, derivatization, cleavage and purification, referred to theinitial loading of the aminomethyl resin given by the supplier (Rapp Polymere GmbH, Tübingen).