Solid phase synthesis of 2-substituted benzofurans via the palladium-catalysed heteroannulation of acetylenes

Tetrahedron Letters

Volumn 38, Issue 13, 1997, Pages 2311-2314

  Fancelli, Daniele ^a   Fagnola, Maria Chiara ^b   Severino, Dino ^a   Bedeschi, Angelo ^b  

^a Med Chem Dept   (Italy)

^b Discovery Research Oncology   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOFURAN DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; METHODOLOGY; REACTION ANALYSIS;

EID: 0031592575     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00301-8     Document Type: Article

References (24)

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23. 2O and dried in vacuo. 2-Phenyl-benzofuran-5-carboxylic acid 7c The resin bound benzofuran derivative 6c was treated with i-PrOH (1.3 ml) and 1N aqueous NaOH (3.3 ml). The resulting mixture was heated at 50°C for 8 hours with occasional shaking, and then left at room temperature overnight The solid support was removed by filtration, the pH of the residual hydroalcoholic solution was adjusted to about 7 with 5N aqueous HCl, and the 2-phenyl-benzofuran-5-carboxylic acid 7c quantitatively assayed.
24. 4 buffer solution for 10 min; area integration at 220 nm.