Palladium-induced cyclizations for the synthesis of cis-2,5-disubstituted-3-methylenetetrahydrofurans: Studies of the C7-C22 core of amphidinolide K

Organic Letters

Volumn 1, Issue 8, 1999, Pages 1303-1305

  Williams, David R ^a   Meyer, Kevin G ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIDINOLIDE K; FURAN DERIVATIVE; FUSED HETEROCYCLIC RINGS; MACROLIDE; PALLADIUM; TETRAHYDROFURAN;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

BICYCLO COMPOUNDS, HETEROCYCLIC; CATALYSIS; FURANS; MACROLIDES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PALLADIUM;

EID: 0033592477     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol990255l     Document Type: Article

References (23)

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23. 3 complexes lead to our cis- and trans2,5-tetrahydrofuran products. However, cyclizations proceeding from isomers as exemplified in i and ii are less favorable than those depicted from 9 and 14 owing to the development of 1,3-nonbonded interactions in transition states leading to C-O bond formation.