Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase

Biochemistry

Volumn 38, Issue 38, 1999, Pages 12343-12357

  Harris, Thomas K ^a   Czerwinski, Robert M ^b   Johnson Jr , William H ^b   Legler, Patricia M ^a   Abeygunawardana, Chitrananda ^a   Massiah, Michael A ^a   Stivers, James T ^a   Whitman, Christian P ^b   Mildvan, Albert S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 OXALOCROTONATE TAUTOMERASE; ARGININE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

ALANINE; ARGININE; BINDING SITES; CATALYSIS; GLUTAMINE; ISOMERASES; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PSEUDOMONAS PUTIDA; RECOMBINANT PROTEINS; SORBIC ACID; STEREOISOMERISM; TITRIMETRY;

EID: 0033592378     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991116e     Document Type: Article

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