7-Nitroindazole prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- induced ATP loss in the mouse striatum

Brain Research

Volumn 839, Issue 1, 1999, Pages 41-48

  Royland, Joyce E ^a   Delfani, Kioumars ^b   Langston, J William ^a   Janson, Ann Marie ^b   Di Monte, Donato A ^a  

^a PARKINSON S INSTITUTE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Dopamine; Mitochondria; Monoamine oxidase; MPP+; Nitric oxide; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 7 NITROINDAZOLE; ADENOSINE TRIPHOSPHATE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; ENERGY METABOLISM; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CORPUS STRIATUM; ENERGY METABOLISM; ENZYME INHIBITORS; INDAZOLES; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITROARGININE;

EID: 0033592133     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01689-3     Document Type: Article

References (31)

1. Babbedge R.C., Bland-Ward P.A., Hart S.L., Moore P.K. Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br. J. Pharmacol. 110:1993;225-228.
2. Castagnoli K., Palmer S., Anderson A., Bueters T., Castagnoli N. Jr. The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Chem. Res. Toxicol. 10:1997;364-368.
3. Chadi G., Møller A., Rosen L., Janson A.M., Agnati L.A., Goldstein M., Ogren S.O., Pettersson R.F., Fuxe K. Protective actions of human recombinant basic fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion. Exp. Brain Res. 97:1993;145-158.
4. Chan P., DeLanney L.E., Irwin I., Langston J.W., Di Monte D. Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain. J. Neurochem. 57:1991;348-351.
5. Chan P., Di Monte D.A., Langston J.W., Janson A.M. (+)MK-801 does not prevent MPTP-induced loss of nigral neurons in mice. J. Pharmacol. Exp. Ther. 280:1997;439-446.
6. + elimination in the mouse striatum. J. Pharmacol. Exp. Ther. 267:1993;1515-1520.
7. Chan P., Langston J.W., Irwin I., DeLanney L.E., Di Monte D.A. 2-Deoxyglucose enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced ATP loss in the mouse brain. J. Neurochem. 61:1993;610-616.
8. Chiba K., Trevor A., Castagnoli N. Jr. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem. Biophys. Res. Commun. 120:1984;574-578.
9. Cleeter M.W., Cooper J.M., Darley-Usmar V.M., Moncada S., Schapira A.H. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345:1994;50-54.
10. Denton T., Howard B.D. A dopaminergic cell line variant resistant to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J. Neurochem. 49:1987;622-630.
11. Di Monte D.A., Royland J.E., Anderson A., Castagnoli K., Castagnoli N. Jr., Langston J.W. Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity. J. Neurochem. 69:1997;1771-1773.
12. Di Monte D.A., Wu E.Y., DeLanney L.E., Irwin I., Langston J.W. Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes. J. Pharmacol. Exp. Ther. 261:1992;44-49.
13. G-nitroarginine in brain in vitro and in vivo. Biochem. Biophys. Res. Commun. 176:1991;1136-1141.
14. Gundersen H.J., Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. J. Microsc. 147:1987;229-263.
15. Heikkila R.E., Manzino L., Cabbat F.S., Duvoisin R.C. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature. 311:1984;467-468.
16. Huang P.L., Dawson T.M., Bredt D.S., Snyder S.H., Fishman M.C. Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 75:1993;1273-1286.
17. Janson A.M., Møller A. Chronic nicotine treatment counteracts nigral cell loss induced by a partial mesodiencephalic hemitransection: an analysis of the total number and mean volume of neurons and glia in substantia nigra of the male rat. Neuroscience. 57:1993;931-941.
18. Kilpatrick I.C., Jones M.W., Phillipson O.T. A semiautomated analysis method for catecholamines, indoleamines, and some prominent metabolites in microdissected regions of the nervous system: an isocratic HPLC technique employing coulometric detection and minimal sample preparation. J. Neurochem. 46:1986;1865-1876.
19. +): identification of a metabolite of MPTP, a toxin selective to the substantia nigra. Neurosci. Lett. 48:1984;87-92.
20. Lemasters J.J., Hackenbrock C.R. Continuous measurement of adenosine triphosphate with firefly luciferase luminescence. Methods Enzymol. 56:1979;530-544.
21. Lizasoain I., Moro M.A., Knowles R.G., Darley-Usmar V., Moncada S. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. Biochem. J. 314:1996;877-880.
22. Lowry O.H., Rosebrough J.J., Farr A.L., Randall R.J. Protein measurement with the Folin reagent. J. Biol. Chem. 193:1951;265-275.
23. Markey S.P., Johannessen J.N., Chiueh C.C., Burns R.S., Herkenham M.A. Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism. Nature. 311:1984;464-467.
24. Nicklas W.J., Vyas I., Heikkila R.E. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 36:1985;2503-2508.
25. Przedborski S., Jackson-Lewis V., Yokoyama R., Shibata T., Dawson V.L., Dawson T.M. Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc. Natl. Acad. Sci. U.S.A. 93:1996;4565-4571.
26. Radi R., Rodriguez M., Castro L., Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Arch. Biochem. Biophys. 308:1994;89-95.
27. Ramsay R.R., Singer T.P. Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria. J. Biol. Chem. 261:1986;7585-7587.
28. J.E. Royland, J.W. Langston, MPTP a dopaminergic neurotoxin, in: R.M. Kosrezewa (Ed.), Highly Selective Neurotoxins: Basic and Clinical Applications, Humana Press, NJ, 1998, pp. 141-194.
29. Schulz J.B., Matthews R.T., Muqit M.M., Browne S.E., Beal M.F. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J. Neurochem. 64:1995;936-939.
30. + levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice. Neurodegeneration. 5:1996;129-136.
31. Walters T.L., Irwin I., Delfani K., Langston J.W., Janson A.M. Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP. Exp. Neurol. 156:1999;62-70.