A synthetic receptor for the Cbz-L-Ala-L-Ala-OH dipeptide sequence

Chemical Communications

Volumn , Issue 14, 1999, Pages 1335-1336

  Henley, Peter D ^a   Kilburn, Jeremy D ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDE; RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; RIGIDITY; SYNTHESIS;

EID: 0033591959     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/a903449h     Document Type: Article

References (19)

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18. The binding constants were calculated by fitting the data to a 1:1 binding isotherm using NMRTit HG software, kindly provided by Professor C. A. Hunter, University of Sheffield. See: A. P. Bisson, C. A. Hunter, J. C. Morales and K. Young, Chem. Eur. J., 1998, 4, 845.
19. In view of the selectivity of macrobicycle 13 for Cbz-L-Ala-L-Ala-OH over Cbz-D-Ala-D-Ala-OH (Table 1, entries 5 and 6), and for Cbz-L-Ala-OH over Cbz-D-Ala-OH (entries 2 and 3), the preference for Cbz-Gly-D-Ala-OH over Cbz-Gly-L-Ala-OH (entries 7 and 8) is somewhat surprising. The origin of this selectivity is unclear at this stage and will need to be examined in further studies.