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Volumn 9, Issue 24, 1999, Pages 3465-3470

Synthesis of 2-(2-adamantyl)piperidines and structure anti-influenza virus A activity relationship study using a combination of NMR spectroscopy and molecular modeling

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PIPERIDINE DERIVATIVE;

EID: 0033590277     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00631-9     Document Type: Article
Times cited : (25)

References (16)
  • 6
    • 84920340785 scopus 로고    scopus 로고
    • Ph.D Thesis (1995)
    • Kolocouris, A. Ph.D Thesis (1995).
    • Kolocouris, A.1
  • 10
    • 85038060574 scopus 로고    scopus 로고
    • note
    • 3, 75 MHz) δ 25.3 (4-C), 27.0 (5-C), 28.0, 28.1, 28.3, 28.7 (7′,5′,3′,1′-C), 30.8 (3-C), 32.2, 32.5 (4′,9′-C), 38.4 (6′-C), 39.1, 39.5 (8′,10′-C), 47.7 (6-C), 49.9 (2′-C), 56.0 (2-C). Spectra and elemental analysis of all the synthesized compounds were in accord with their structure.
  • 14
    • 0033587175 scopus 로고    scopus 로고
    • - orientation around C2-C2′ bond. Conformers A-D with an anti orientation around C2-C2′ bond were found to have the lowest energy content. For further details see
    • - orientation around C2-C2′ bond. Conformers A-D with an anti orientation around C2-C2′ bond were found to have the lowest energy content. For further details see: Mavromoustakos, T.; Kolocouris, A.; Zervou, M.; Roumelioti, P.; Matsoukas, J. M.; Weisemann, R. J. Med. Chem. 1999, 42, 1714-1722.
    • (1999) J. Med. Chem. , vol.42 , pp. 1714-1722
    • Mavromoustakos, T.1    Kolocouris, A.2    Zervou, M.3    Roumelioti, P.4    Matsoukas, J.M.5    Weisemann, R.6
  • 15
    • 33845379406 scopus 로고
    • Calculations of the relative energies of conformations A-D were performed using MM2 calculations. These calculations give the most consistent results with experimental data for six-membered nitrogen heterocycles as describen by. The MM+ force field provided by the Hyperchem was used. This force field is an extension of MM2 force field
    • Calculations of the relative energies of conformations A-D were performed using MM2 calculations. These calculations give the most consistent results with experimental data for six-membered nitrogen heterocycles as describen by Profeta, S.; Allinger, N. L. J. Am. Chem. Soc. 1985, 107, 1907-1918. The MM+ force field provided by the Hyperchem was used. This force field is an extension of MM2 force field.
    • (1985) J. Am. Chem. Soc. , vol.107 , pp. 1907-1918
    • Profeta, S.1    Allinger, N.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.