Synthesis and anti-HIV activity of some new aminoadamantane heterocycles

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 14, 1997, Pages 1887-1890

  Fytas, G ^a   Stamatiou, G ^a   Foscolos, G B ^a   Kolocouris, A ^a   Kolocouris, N ^a   Witvrouw, M ^b   Pannecouque, C ^b   De Clercq, E ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMANTANE DERIVATIVE; ANTIVIRUS AGENT;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; REACTION ANALYSIS;

EID: 0030743225     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00320-X     Document Type: Article

References (9)

1. (a) In Burger's Medicinal Chemistry; Wolff, M. E., Ed.; John Wiley & Sons: New York, 1981; Part II, pp 557-560.
2. (b) Hay, A. J. Semin. Virol. 1992, 3, 21.
3. Kolocouris, N.; Foscolos, G. B.; Kolocouris A.; Marakos, P.; Pouli, N.; Fytas, G.; Ikeda, S.; De Clercq, E. J. Med. Chem. 1994, 37, 2896.
4. Kolocouris, N.; Kolocouris A.; Foscolos G. B.; Fytas, G.; Neyts, J.; Padalko, E.; Balzarini, J.; Snoeck, R.; Andrei, G.; De Clercq, E. J. Med. Chem. 1996, 39, 3307.
5. Fytas, G.; Kolocouris, N.; Foscolos, G. B.; Vamvakides, A. Eur. J. Med. Chem. 1991, 26, 563.
6. 3, 50 MHz) δ 19.6 (4-piperidine C), 21.9 (5-piperidine C), 23.5 (3-piperidine C), 28.4 (3,5,7-adamantane C), 36.8 (4,6,10-adamantane C), 39.6 (2,8,9-adamantane C), 41.3 (1-adamantane C), 49.1 (6-piperidine C), 177.0 (2-piperidine C).
7. Astier, A.; Plat, M. Tetrahedron Lett. 1978, 2051.
8. Satisfactory analytical results were obtained for all new compounds. The spectral properties were in accord with the assigned structures.
9. Pauwels, R.; Balzarini, J.; Baba, M.; Snoeck, R.; Schols, D.; Herdewyn, P.; Desmyter, J.; De Clercq, E. J. Virol. Methods 1988, 20, 309.