Construction of sequence-selective peptide receptors from conformationally restricted eta- and theta-amino acids

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 18, 1999, Pages 2673-2678

  Ryan, Kevin ^a   Still, W Clark ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; TRIPEPTIDE;

ARTICLE; MOLECULAR RECOGNITION; PEPTIDE SYNTHESIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

AMINO ACIDS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; RECEPTORS, PEPTIDE;

EID: 0033588907     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00463-1     Document Type: Article

References (10)

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2. 2. Still, W. C. Acc. Chem. Res. 1996, 29, 155.
3. 3. Gellman, S. H. Acc. Chem. Res. 1998, 31, 173.
4. 1H NMR and FABMS.
5. 5. Reddy, D. R.; Thornton, E. R. J. Chem. Soc., Chem. Commun. 1992, 172.
6. 4NF in DMF (24 h).
7. 10
8. 3 potential sequences of the structure: Ac-AA3-AA2-AA1-HN-polystyrene, where AAn represents Gly and the d or 1 isomers of: Ala, Ser, Val, Pro, Asn, Gln, and Lys.
9. 9. Macromodel 6.0®: Mohamadi, F.; Richards, N. G. J.; Guida, W. C.; Liskamp, R.; Lipton, M.; Caulfield, C.; Chang, G.; Hendrickson, T.; Still, W. C. J. Comput. Chem. 1990, 11, 440. (MM2 forcefield, chloroform, 2000 Monte Carlo steps, 1000 minimization steps using PRCG method.)
10. 10. Ohlmeyer, M. H. J.; Swanson, R. N.; Dillard, L. W.; Reader, J. C.; Asouline, G.; Kobayashi, R.; Wigler, M.; Still, W. C. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 10922.