Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme

Journal of Molecular Biology

Volumn 291, Issue 3, 1999, Pages 531-536

  Bachhawat, Nandita ^a   Mande, Shekhar C ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

INO1; Inositol; Inositol 1 phosphate synthase; Mycobacterium tuberculosis; Sequence threading

Indexed keywords

INOSITOL; MYOINOSITOL 1 PHOSPHATE SYNTHASE;

AMINO ACID SEQUENCE; ARTICLE; ASSAY; BIOSYNTHESIS; EUKARYOTE; GENE CONSTRUCT; GENE EXPRESSION; MOLECULAR CLONING; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; YEAST;

MYCOBACTERIUM TUBERCULOSIS;

EID: 0033588069     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.2980     Document Type: Article

References (30)

1. Altschul S. F., Madden T. L., Madden A. A., Schaffer A. A., Zhang J., Zhang Z., Miller W., Lipman D. J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucl. Acids. Res. 25:1997;3389-3402.
2. Bachhawat N., Ouyang Q., Henry S. A. Functional characterization of an inositol-sensitive upstream activation sequence in yeast. J. Biol. Chem. 270:1995;25087-25095.
3. Besra G. S., Morehouse C. B., Rittner C. M., Waechter C. J., Brennan P. J. Biosynthesis of mycobacterial lipoarabinomannan. J. Biol. Chem. 272:1997;18460-18466.
4. Bornemann C., Jardine C. M. A., Spies H. S. C., Steenkamp D. J. Biosynthesis of mycothiol: elucidation of the sequence of steps in Mycobacterium smegmatis. Biochem. J. 325:1997;623-629.
5. Chan J., Fan X., Hunter S. W., Brennan P. J., Bloom B. R. Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect. Immun. 59:1991;1755-1761.
6. Chatterjee D., Hunter S. W., Michael M., Brennan P. J. Lipoarabinomannan. multiglycosylated form of the mycobacterial mannosylphophatidylinositols. J. Biol. Chem. 267:1992;6228-6233.
7. Chen I., Charalompous F. C. Biochemical studies on inositol. VII. Biosynthesis of inositol by a soluble enzyme system. J. Biol. Chem. 239:1964;1905-1910.
8. Chen I., Charalompous F. C. Inositol-1-phosphate as intermediate in the conversion of glucose-6-phosphate to inositol. Biochem. Biophys. Res. Commun. 19:1965;144-149.
9. Cole S. T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 393:1998;537-544.
10. Culbertson M. R., Henry S. A. Inositol-requiring mutants of Saccharomyces cerevisiae. Genetics. 80:1975;23-40.
11. Fischer D., Eisenberg D. Protein fold recognition using sequence-derived prediction. Protein Sci. 5:1996;947-955.
12. Greenberg M. L., Reiner B., Henry S. A. Regulatory mutations of inositol biosynthesis in yeast: isolation of inositol excreting mutants. Genetics. 100:1982;19-33.
13. Gumber S. C., Loewus M. W., Loewus F. A. myo -Inositol-1-phosphate synthase from Pine pollen: sulfhydryl involvement at the active site. Arch. Biochem. Biophys. 231:1984;372-377.
14. Hofmann K., Bucher P., Falquet L., Bairoch A. The PROSITE database, its status in 1999. Nucl. Acids. Res. 27:1999;215-219.
15. Hunter S. W., Brennan P. J. Evidence for the presence of a phosphatidylinositol anchor on the lipoarabinomannan and lipomannan of Mycobacterium tuberculosis. J. Biol. Chem. 265:1990;9272-9279.
16. Ito H., Fukuda Y., Murata K., Kimura A. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:1983;163-168.
17. Khoo K., Dell A., Morris H. R., Brennan P. J., Chatterji D. Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains ofMycobacterium. J. Biol. Chem. 270:1995;12380-12389.
18. Kozloff L. M., Turner M. A., Arellano F., Lute M. Phosphatidylinositol, a phospholipid of ice-nucleating bacteria. J. Bacteriol. 173:1991;2053-2060.
19. Kraulis P. J. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallog. 90:1991;946-950.
20. Majumdar A. L., Johnson M. D., Henry S. A. 1L- myo -inositol-1-phosphate synthase. Biochim. Biophys. Acta. 1348:1997;245-256.
21. Mumberg D., Muller R., Funk M. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgroups. Gene. 156:1995;119-122.
22. Newton G. L., Arnold K., Price M. S., Sherrill C., Delcardayre S. B., Aharonowitz Y., Cohen G., Davies J., Fahey R. C., Davis C. Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. J. Bacteriol. 178:1996;1990-1995.
23. Parish T., Liu J., Nikaido H., Stoker N. G. A Mycobacterium smegmatis mutant with a defective inositol monophosphatase gene homolog has altered envelope permeability. J. Bacteriol. 179:1997;7827-7833.
24. Pittner F., Tovarova I. I., Kornitskaya E. Y., Khokhlov A. S., Hoffmann-Ostenhof O. myo -Inositol-1-phosphate synthase from Streptomyces griseus. Mol. Cell. Biochem. 25:1979;43-46.
25. Salman M., Lonsdale J. T., Besra G. S., Brennan P. J. Phosphatidylinositol synthesis in mycobacteria. Biochem. Biophys. Acta. 1436:1999;437-450.
26. Sambrook J., Fritch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
27. Scapin G., Reddy S. G., Blanchard J. S. Three dimensional structure of meso -diaminopimelic acid dehydrogenase from Corynebacterium glutamicum. Biochem. 35:1996;13540-13551.
28. Schlesinger L. S., Hull S. R., Kaufman T. M. Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages. J. Immunol. 152:1994;4070-4079.
29. Sibley L. D., Hunter S. W., Brennan P. J., Krahenbuhl J. L. Mycobacterial lipoarabinomannan inhibits gamma-interferon mediated activation of macrophages. Infect. Immun. 56:1988;1232-1236.
30. Wierenga R. K., Terpstra P., Hol W. G. J. Prediction of the occurrence of the ADP-binding βαβ fold in proteins using an amino acid sequence fingerprint. J. Mol. Biol. 187:1986;101-107.