A new method for rapidly generating inhibitors of glyoxalase I inside tumor cells using S-(N-aryl-N-hydroxycarbamoyl)ethylsulfoxides

Journal of Medicinal Chemistry

Volumn 42, Issue 10, 1999, Pages 1823-1827

  Hamilton, Diana S ^a   Kavarana, Malcolm J ^a   Sharkey, Ellyn M ^a   Eiseman, Julie L ^b   Creighton, Donald J ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(N 4 CHLOROPHENYL N HYDROXYCARBAMOYL)ETHYLSULFOXIDE; (N 4 CHLOROPHENYL N HYDROXYCARBAMOYL)GLUTATHIONE; ENZYME INHIBITOR; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LACTOYLGLUTATHIONE LYASE; PRODRUG; SULFOXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL MEMBRANE PERMEABILITY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG STABILITY; DRUG SYNTHESIS; LEUKEMIA L 1210; MOUSE; NONHUMAN; REACTION ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL MEMBRANE PERMEABILITY; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; KINETICS; LACTOYLGLUTATHIONE LYASE; LEUKEMIA L1210; MICE; MICE, INBRED DBA; PLACENTA; PRODRUGS; TUMOR CELLS, CULTURED;

EID: 0033587108     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980712o     Document Type: Article

References (17)

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