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84920310141
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Restoration of proteolytic activity was possible after purification of the monomer by nickel affinity chromatography, followed by dialysis.
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84920310140
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Under denaturing conditions, in the presence of 6 M urea and 2 mM catalyst, Pd-catalyzed deblocking afforded an active protease monomer having a specific activity 85% that of wild type (16 h incubation. 23°C). whereas the caged enzyme was inactive (Supporting Information. Figure 3).
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43
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That the formed dimer had a structure fundamentally analogous to that of the native enzyme can be appreciated by the full restoration of enzymic activity following irradiation of the caged dimer (Figure 2).
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