Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain Mne produce virions that are replication defective in vitro and in vivo

Virology

Volumn 253, Issue 2, 1999, Pages 259-270

  Gorelick, Robert J ^a   Benveniste, Raoul E ^b   Gagliardi, Tracy D ^a   Wiltrout, Theresa A ^a   Busch, Laura K ^a   Bosche, William J ^a   Coren, Lori V ^a   Lifson, Jeffrey D ^a   Bradley, Patricia J ^a   Henderson, Louis E ^a   Arthur, Larry O ^a  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; NUCLEOCAPSID PROTEIN; VIRUS PROTEIN; VIRUS RNA; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MURINE LEUKEMIA VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; ROUS SARCOMA ONCOVIRUS; SIMIAN IMMUNODEFICIENCY VIRUS; VIRION; VIRUS INFECTIVITY; VIRUS NUCLEOCAPSID; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA NEMESTRINA; MAMMALIA; MURINAE; MURINE LEUKEMIA VIRUS; ONCOVIRINAE; PRIMATES; RNA VIRUSES; ROUS SARCOMA VIRUS; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; SUS SCROFA;

EID: 0033585384     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9513     Document Type: Article

References (41)

1. Aldovini, A., and Young, R. A. (1990). Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus. J. Virol. 64, 1920-1926.
2. Aronoff, R., Hajjar, A. M., and Linial, M. L. (1993). Avian retroviral RNA encapsidation: Reexamination of functional 5′ RNA sequences and the role of nucleocapsid Cys-His motifs. J. Virol. 67, 178-188.
3. Benveniste, R. E., Arthur, L. O., Tsai, C.-C., Sowder, R., Copeland, T. D., Henderson, L. E., and Oroszlan, S. (1986). Isolation of a lentivirus from a macaque with lymphoma: Comparison with HTLV-III/LAV and other lentiviruses. J. Virol. 60, 483-490.
4. Benveniste, R. E., Heidecker, G., Greenwood, J., and Gonda, M. A. (1990). SIV(Mne), Genbank accession number: M32741. In "Human Retroviruses and AIDS, 1990: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences" (G. Myers, J. A. Berzofsky, A. B. Rabson, T. F. Smith, and F. Wong-Staal, Eds.), pp. I-A-64-I-A-76. Los Alamos National Laboratory, Los Alamos, New Mexico.
5. Benveniste, R. E., Kuller, L., Roodman, S. T., Hu, S. L., and Morton, W. R. (1993). Long-term protection of macaques against high-dose type D retrovirus challenge after immunization with recombinant vaccinia virus expressing envelope glycoproteins. J. Med. Primatol. 22, 74-79.
6. Benveniste, R. E., Morton, W. R., Clark, E. A., Tsai, C. C., Ochs, H. D., Ward, J. M., Kuller, L., Knott, W. B., Hill, R. W., Gale, M. J., and Thouless, M. E. (1988). Inoculation of baboons and macaques with simian immunodeficiency virus/Mne, a primate lentivirus closely related to human immunodeficiency virus type 2. J. Virol. 62, 2091-2101.
7. Benveniste, R. E., Roodman, S. T., Hill, R. W., Knott, W. B., Ribas, J. L., Lewis, M. G., and Eddy, G. A. (1994). Infectivity of titered doses of simian immunodeficiency virus clone E11S inoculated intravenously into rhesus macaques (Macaca mulatta). J. Med. Primatol. 23, 83-88.
8. Berg, J. M. (1986). Potential metal-binding domains in nucleic acid binding proteins. Science 232, 485-487.
9. Bess, J. W., Jr., Powell, P. J., Issaq, H. J., Schumack, L. J., Grimes, M. K., Henderson, L. E., and Arthur, L. O. (1992). Tightly bound zinc in human immunodeficiency virus type 1, human T-cell leukemia virus type I, and other retroviruses. J. Virol. 66, 840-847.
10. Casas-Finet, J. R., Urbaneja, M. A., McGrath, C., Gorelick, R. J., Bosche, W. J., Kane, B. P., Arthur, L. O., Henderson, L. E., Lee, B. M., DeGuzman, R. N., and Summers, M. F. (1997a). Conformational heterogeniety in HIV-1 nucleocapsid protein p7. Biophys. J. 72, A133.
11. Casas-Finet, J. R., Urbaneja, M. A., Nower, P. N., Gorelick, R. J., Bosche, W. J., Kane, B. P., Johnson, D., and Henderson, L. E. (1997b). Functional properties of point-mutated MoMuLV nucleocapsid (NC) protein p10. FASEB J. 11, A981.
12. Chaffee, S., Leeds, J. M., Matthews, T. J., Weinhold, K. J., Skinner, M., Bolognesi, D. P., and Hershfield, M. S. (1988). Phenotypic variation in the response to the human immunodeficiency virus among derivatives of the CEM T and WIL-2 B cell lines. J. Exp. Med. 168, 605-621.
13. Covey, S. N. (1986). Amino acid sequence homology in gag region of reverse transcribing elements and the coat protein gene of cauliflower mosaic virus. Nucleic Acids Res. 14, 623-633.
14. DeGuzman, R. N., Wu, Z. R., Stalling, C. C., Pappalardo, L., Borer, P. N., and Summers, M. F. (1998). Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element. Science 279, 384-388.
15. Dorfman, T., Luban, J., Goff, S. P., Haseltine, W. A., and Gottlinger, H. G. (1993). Mapping of functionally important residues of a cysteinehistidine box in the human immunodeficiency virus type 1 nucleocapsid protein. J. Virol. 76, 6159-6169.
16. Dupraz, P., Oertle, S., Meric, C., Damay, P., and Spahr, P.-F. (1990). Point mutations in the proximal Cys-His box of Rous sarcoma virus nucleocapsid protein. J. Virol. 64, 4978-4987.
17. Fu, W., Gorelick, R. J., and Rein, A. (1994). Characterization of human immunodeficiency virus type 1 dimeric RNA from wild-type and protease-defective virions. J. Virol. 68, 5013-5018.
18. Fu, W., and Rein, A. (1993). Maturation of dimeric viral RNA of Moloney murine leukemia virus. J. Virol. 67, 5443-5449.
19. Gibson, U. E. M., Heid, C. A., and Williams, P. M. (1996). A novel method for real time quantitative RT PCR. Genome Res. 6, 995-1001.
20. Gonda, M. A., Aaronson, S. A., Ellmore, N., Zeve, V. H., and Nagashima, K. (1976). Ultrastructural studies of surface features of human normal and tumor cells in tissue culture by scanning and transmission electron microscopy. J. Natl. Cancer. Inst 56, 245-263.
21. Gorelick, R. J., Chabot, D. J., Ott, D. E., Gagliardi, T. D., Rein, A., Henderson, L. E., and Arthur, L. O. (1996). Genetic analysis of the zinc finger in the moloney murine leukemia virus nucleocapsid domain: Replacement of zinc-coordinating residues with other zinc-coordinating residues yields noninfectious particles containing genomic RNA. J. Virol. 70, 2593-2597.
22. Gorelick, R. J., Chabot, D. J., Rein, A., Henderson, L. E., and Arthur, L. O. (1993). The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent. J. Virol. 67, 4027-4036.
23. Gorelick, R. J., Henderson, L. E., Hanser, J. P., and Rein, A. (1988). Point mutants of Moloney murine leukemia virus that fail to package viral RNA: Evidence for specific RNA recognition by a "zinc finger-like" protein sequence. Proc. Natl. Acad Sci. USA 85, 8420-8424.
24. Gorelick, R. J., Nigida, S. M., Jr., Bess, J. W., Jr., Arthur, L. O., Henderson, L. E., and Rein, A. (1990). Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. J. Virol. 64, 3207-3211.
25. Heid, C. A., Stevens, J., Livak, K. J., and Williams, P. M. (1996). Real time quantitative PCR. Genome Res. 6, 986-994.
26. Heidecker, G., Munoz, H., Hodge, L. D., Ruscetti, F. W., Morton, W. R., Hu, S. L., and Benveniste, R. E. (1998). Macaques infected with cloned simian immunodeficiency virus show recurring nef gene alterations. Virology 249, 260-274.
27. Henderson, L. E., Benveniste, R. E., Sowder, R., Copeland, T. D., Schultz, A. M., and Oroszlan, S. (1988). Molecular characterization of Gag proteins from simian immunodeficiency virus (SIVMne). J. Virol. 62, 2587-2595.
28. Korber, B., Foley, B., Leitner, T., McCutchan, F., Hahn, B., Mellors, J. W., Myers, G., and Kuiken, C., Eds. (1997). "Human retroviruses and AIDS 1997: A compilation and analysis of nucleic acid and amino acid sequences," p. II-B-6. Los Alamos National Laboratory, Los Alamos, New Mexico.
29. Krishna, N. K., Campbell, S., Vogt, V. M., and Wills, J. W. (1998). Genetic determinants of Rous sarcoma virus particle size. J. Virol. 72, 564-577.
30. + depletion and AIDS. J. Med. Primatol. 23, 397-409.
31. Maurer, B., Bannert, H., Darai, G., and Flugel, R. M. (1988). Analysis of the primary structure of the long terminal repeat and the gag and pol genes of the human spumaretrovirus. J. Virol. 62, 1590-1597.
32. Meric, C., Gouilloud, E., and Spahr, P.-F. (1988). Mutations in Rous sarcoma virus nucleocapsid protein p12 (NC): Deletions of Cys-His boxes. J. Virol. 62, 3328-3333.
33. Poon, D. T., Li, G., and Aldovini, A. (1998). Nucleocapsid and matrix protein contributions to selective human immunodeficiency virus type 1 genomic RNA packaging. J. Virol. 72, 1983-1993.
34. Poon, D. T. K., Wu, J., and Aldovini, A. (1996). Charged amino acid residues of human immunodeficiency virus type 1 nucleopcapsid p7 involved in RNA packaging and infectivity. J. Virol. 70, 6607-6616.
35. Rein, A., Harvin, D. P., Mirro, J., Ernst, S. M., and Gorelick, R. J. (1994). Evidence that a central domain of nucleocapsid protein is required for RNA packaging in murine leukemia virus. J. Virol. 68, 6124-6129.
36. Sakalian, M., Wills, J. W., and Vogt, V. M. (1994). Efficiency and selectivity of RNA packaging by Rous sarcoma virus Gag deletion mutants. J. Virol. 68, 5969-5981.
37. Southern, P. J., and Berg, P. (1982). Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1, 327-341.
38. Stewart, L., Schatz, G., and Vogt, V. M. (1990). Properties of avian retrovirus particles defective in viral protease. J. Virol. 64, 5076-5092.
39. Suryanarayana, K., Wiltrout, T. A., Vasquez, G. M., Hirsch, V. M., And Lifson, J. D. (1998). Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction. AIDS Res. Hum. Retroviruses 14, 183-189.
40. Tanchou, V., Decimo, D., Pechoux, C., Lener, D., Rogemond, V., Berthoux, L., Ottmann, M., and Darlix, J. L. (1998). Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replication. J. Virol. 72, 4442- 4447.
41. Tsai, C. C., Follis, K. E., Grant, R. F., Nolte, R. E., Wu, H., and Benveniste, R. E. (1993). Infectivity and pathogenesis of titered dosages of simian immunodeficiency virus experimentally inoculated into longtailed macaques (Macaca fascicularis). Lab. Anim. Sci. 43, 411-416.