Macaques infected with cloned simian immunodeficiency virus show recurring nef gene alterations

Virology

Volumn 249, Issue 2, 1998, Pages 260-274

  Heidecker, G ^a   Munoz H ^a   Lloyd, P ^a   Hodge, D ^b   Ruscetti, F W ^b   Morton, W R ^c   Hu, S L ^c   Benveniste, R E ^b  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE ISOLATION; MACACA; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS GENE; VIRUS MUTATION;

EID: 0032581992     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9325     Document Type: Article

References (63)

1. Ahmad N., Venkatesan S. Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR. Science. 241:1988;1481-1485.
2. Arthur L. O., Bess J. W. Jr., Urban R. G., Strominger J. L., Morton W. R., Mann D. L., Henderson L. E., Benveniste R. E. Macaques immunized with HLA-DR are protected from challenge with Simian immunodeficiency virus. J. Virol. 69:1995;3117-3124.
3. Baur A. S., Sawai E. T., Dazin P., Fantl W. J., Cheng-Mayer C., Peterlin B. M. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity. 1:1994;373-384.
4. Benveniste R. E., Arthur L. O., Tsai C. C., Sowder R., Copeland T. D., Henderson L. E., Oroszlan S. Isolation of a lentivirus from a macaque with lymphoma: comparison with HTLV-III/LAV and other lentiviruses. J. Virol. 60:1986;483-490.
5. Benveniste R. E., Morton W. R., Clark E. A., Tsai C. C., Ochs H. D., Ward J. M., Kuller L., Knott W. B., Hill R. W., Gale M. J. Inoculation of baboons and macaques with Simian immunodeficiency virus/Mne, a primate lentivirus closely related to human immunodeficiency virus type 2. J. Virol. 62:1988;2091-2101.
6. Benveniste R. E., Raben D., Hill R. W., Knott W. B., Drummond J. E., Arthur L. O., Jahrling P. B., Morton W. R., Henderson L. E., Heidecker G. Molecular characterization and comparison of Simian immunodeficiency virus isolates from macaques, mangabeys, and African green monkeys. J. Med. Primatol. 18:1989;287-303.
7. Benveniste R. E., Hill R. W., Eron L. J., Csaikl U. M., Knott W. B., Henderson L. E., Sowder R. C., Nagashima K., Gonda M. A. Characterization of clones of HIV-1 infected HuT 78 cells defective in gag gene processing and of SIV clones producing large amounts of envelope glycoprotein. J. Med. Primatol. 19:1990;351-366.
8. Benveniste R. E., Roodman S. T., Hill R. W., Knott W. B., Ribas J. L., Lewis M. G., Eddy G. A. Infectivity of titered doses of Simian immunodeficiency virus clone E11S inoculated intravenously into rhesus macaques (Macaca mulatta. J. Med. Primatol. 23:1994;83-88.
9. Blumberg B., Epstein L., de Ronde A., Goudsmit J. HIV1 3′ ORF is open in pathological tissue and accelerates viral replication in primary lymphocytes. Res. Virol. 143:1992;63-65.
10. Chackerian B., Haigwood N. L., Overbaugh J. Characterization of a CD4-expressing macaque cell line that can detect virus after a single replication cycle and can be infected by diverse Simian immunodeficiency virus isolates. Virology. 213:1995;386-394.
11. Chowers M. Y., Pandori M. W., Spina C. A., Richman D. D., Guatelli J. C. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology. 212:1995;451-457.
12. Clerici M., Clark E. A., Polacino P., Axberg I., Kuller L., Casey N. I., Morton W. R., Shearer G. M., Benveniste R. E. T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques. AIDS. 8:1994;1391-1395.
13. de Ronde A., Klaver B., Keulen W., Smit L., Goudsmit J. Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes. Virology. 188:1992;391-395.
14. Deacon N. J., Tsykin A., Solomon A., Smith K., Ludford-Menting M., Hooker D. J., McPhee D. A., Greenway A. L., Ellett A., Chatfield C. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science. 270:1995;988-991.
15. Du Z., Ilyinskii P. O., Sasseville V. G., Newstein M., Lackner A. A., Desrosiers R. C. Requirements for lymphocyte activation by unusual strains of Simian immunodeficiency virus. J. Virol. 70:1996;4157-4161.
16. Fisher A. G., Ratner L., Mitsuya H., Marselle L. M., Harper M. E., Broder S., Gallo R. C., Wong-Staal F. Infectious mutants of HTLV-III with changes in the 3′ region and markedly reduced cytopathic effects. Science. 233:1986;655-659.
17. Foti M., Mangasarian A., Piguet V., Lew D. P., Krause K. H., Trono D., Carpentier J. L. Nef-medciated clathrin-coated pit formation. J. Cell Biol. 139:1997;37-47.
18. Franchini G., Robert-Guroff M., Ghrayeh J., Chang N. T., Wong-Stall F. Cytoplasmic localization of the HTLV-III 3′ orf protein in cultured T-cells. Virology. 155:1986;593-599.
19. Frischauf A. M., Lehrach H., Poustka A., Murray N. Lambda replacement vectors carrying polylinker sequences. J. Mol. Biol. 170:1983;827-842.
20. Garcia J. V., Miller A. D. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature. 350:1991;508-511.
21. Garcia J. V., Foster J. L. Structural and functional correlates between HIV-1 and SIV Nef isolates. Virology. 226:1996;161-166.
22. Greenberg M. E., Bronson S., Lock M., Neumann M., Pavlakis G. N., Skowronski J. Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J. 16:1997;6964-6976.
23. Grzesiek S., Bax A., Clore G. M., Gronenborn A. M., Hu J. S., Kaufman J., Palmer I., Stahl S. J., Wingfield P. T. The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nat. Struct. Biol. 3:1996;340-345.
24. Grzesiek S., Bax A., Hu J. S., Kaufman J., Palmer I., Stahl S. J., Tjandra N., Wingfield P. T. Refined solution structure and backbone dynamics of HIV-1 Nef. Protein Sci. 6:1997;1248-1263.
25. Guy B., Kieny M. P., Riviere Y., Le Peuch C., Dott K., Girard M., Montagnier L., Lecocq J. P. HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature. 330:1987;266-269.
26. Hammes S. R., Dixon E. P., Malim M. H., Cullen B. R., Greene W. C. Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor. Proc. Natl. Acad. Sci. USA. 86:1989;9549-9553.
27. Harris M. From negative factor to a critical role in virus pathogenesis: the changing fortunes of Nef. J. Gen. Virol. 77:1996;2379-2392.
28. Henderson L. E., Benveniste R. E., Sowder R., Copeland T. D., Schultz A. M., Oroszlan S. Molecular characterization of gag proteins from Simian immunodeficiency virus (SIVMne). J. Virol. 62:1988a;2587-2595.
29. Henderson L. E., Sowder R. C., Copeland T. D., Benveniste R. E., Oroszlan S. Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2. Science. 241:1988b;199-201.
30. Higgins D. G., Sharp P. M. Fast and sensitive multiple sequence alignments on a microcompouter. Comput. Appl. Biosci. 5:1989;151-153.
31. Higuchi R. PCR Technology. 1989;Stockton Press, New York. p. 31-38.
32. Hirsch V., Riedel N., Kornfeld H., Kanki P. J., Essex M., Mullins J. I. Cross-reactivity to human T-lymphotropic virus type III/lymphadenopathy-associated virus and molecular cloning of Simian T-cell lymphotropic virus type III from African green monkeys. Proc. Natl. Acad. Sci. USA. 83:1986;9754-9758.
33. Hu S. L., Abrams K., Barber G. N., Moran P., Zarling J. M., Langlois A. J., Kuller L., Morton W. R., Benveniste R. E. Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160. Science. 255:1992;456-459.
34. Kaminchik J., Bashan N., Pinchasi D., Amit B., Sarver N., Johnston M. I., Fischer M., Yavin Z., Gorecki M., Panet A. Expression and biochemical characterization of human immunodeficiency virus type 1 nef gene product. J. Virol. 64:1990;3447-3454.
35. Kestler H. W., Naidu Y. N., Kodama T., King N. W., Daniel M. D., Li Y., Desrosiers R. C. Use of infectious molecular clones of Simian immunodeficiency virus for pathogenesis studies. J. Med. Primatol. 18:1989;305-309.
36. Kestler H. W., Ringler D. J., Mori K., Panicali D. L., Sehgal P. K., Daniel M. D., Desrosiers R. C. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell. 65:1991;651-662.
37. Kim S., Ikeuchi K., Byrn R., Groopman J., Baltimore D. Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA. 86:1989;9544-9548.
38. +. J. Med. Primatol. 23:1994;397-409.
39. Lee C. H., Saksela K., Mirza U. A., Chait B. T., Kuriyan J. Crystal structure of the conserved core of HIV-1 Nef complexes with a Src family SH3 domain. Cell. 85:1996;931-942.
40. Luciw P. A., Chang-Mayer C., Levy J. A. Mutational analysis of the human immune deficiency virus: the ORF-B region down regulates virus replication. Proc. Natl. Acad. Sci. USA. 84:1987;1434-1438.
41. Luo T., Foster J. L., Garcia J. V. Molecular determinants of Nef function. J. Biomed. Sci. 4:1997;132-138.
42. Luo T., Garcia J. V. Regulation of Nef function. Res. Virol. 148:1997;64-68.
43. Mariani R., Skowronski J. CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals. Proc. Natl. Acad. Sci. USA. 90:1993;5549-5553.
44. Mariani R., Kirchhoff F., Greenough T. C., Sullivan J. L., Desrosiers R. C., Skowronski J. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J. Virol. 70:1996;7752-7764.
45. Messing J., Crea R., Seeburg P. H. A system for shotgun DNA sequencing. Nucleic Acids Res. 9:1981;309-321.
46. Michael N. L., Chang G., d'Arcy L. A., Ehrenberg P. K., Mariani R., Busch M. P., Birx D. L., Schwartz D. H. Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virus. J. Virol. 69:1995;4228-4236.
47. Niederman T. M., Garcia J. V., Hastings W. R., Luria S., Ratner L. Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells. J. Virol. 66:1992;6213-6219.
48. Niederman T. M., Hastings W. R., Luria S., Bandres J. C., Ratner L. HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells. Virology. 194:1993;338-344.
49. Overbaugh J., Rudensey L. M., Papenhausen M. D., Benveniste R. E., Morton W. R. Variation in Simian immunodeficiency virus env is confined to V1 and V4 during progression to Simian AIDS. J. Virol. 65:1991;7025-7031.
50. Pandori M. W., Fitch N. J., Craig H. M., Richman D. D., Spina C. A., Guatelli J. C. Prodicer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein. J. Virol. 70:1996;4283-4290.
51. Reinhart T. A., Rogan M. J., Haase A. T. RNA splice site utilization by Simian immunodeficiency viruses derived from sooty mangabey monkeys. Virology. 224:1996;338-344.
52. Rudensey L. M., Kimata J. T., Benveniste R. E., Overbaugh J. Progression to AIDS in macaques is associated with changes in the replication, tropism, a and cytopathic properties of the Simian immunodeficiency virus variant population. Virology. 207:1995;528-542.
53. Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
54. Shafferman A., Jahrling P. B., Benveniste R. E., Lewis M. G., Phipps T. J., Eden-McCutchan F., Sadoff J., Eddy G. A., Burke D. S. Protection of macaques with a Simian immunodeficiency virus envelope peptide vaccine based on conserved human immunodeficiency virus type 1 sequences. Proc. Natl. Acad. Sci. USA. 88:1991;7126-7130.
55. Shugars D. C., Smith M. S., Glueck D. H., Nantermet P. V., Seillier-Moiseiwitsch F., Swanstrom R. Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo. J. Virol. 67:1993;4639-4650.
56. Su L., Kaneshima H., Bonyhadi M. L., Lee R., Auten J., Wolf A., Du B., Rabin L., Hahn B. H., Terwilliger E., Mccune J. M. Identification of HIV-1 determinants for replication in vivo. Virology. 227:1997;45-52.
57. Terwilliger E. F., Langhoff E., Gabuzda D., Zazopoulos E., Haseltine W. A. Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA. 88:1991;10971-10975.
58. Tokunaga K. Function of human immunodeficiency virus type 1 nef gene product in virus replication. Hokkaido. Igaku. Zasshi. 71:1996;345-357.
59. Trono D. HIV accessory proteins: leading roles for the supporting cast. Cell. 82:1995;189-192.
60. Tsai C. C., Follis K. E., Grant R. F., Nolte R. E., Wu H., Benveniste R. E. Infectivity and pathogenesis of titered dosages of Simian immunodeficiency virus experimentally inoculated into longtailed macaques (Macaca fascicularis. Lab. Anim. Sci. 43:1993;411-416.
61. Wiskerchen M., Cheng-Mayer C. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. Virology. 224:1996;292-301.
62. Zhu G. W., Mukherjee S, . Sahni M., Narayan O., Stephens E. B. Prolonged infection in rhesus macaques with Simian immunodeficiency virus (SIVmac239) results in animal-specific and rarely tissue-specific selection of nef variantes. Virology. 220:1996;522-529.
63. Zhu T., Mo H., Wang N., Nam D. S., Cao Y., Koup R. A., Ho D. D. Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science. 261:1993;1179-1181.