-
1
-
-
0026611521
-
1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines
-
1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines. J Med Chem 1992, 35: 2274-83.
-
(1992)
J Med Chem
, vol.35
, pp. 2274-2283
-
-
Sauerberg, P.1
Olesen, P.H.2
Nielsen, S.3
-
2
-
-
10544237867
-
-
Heterocyclic cpds. and their preparation and use. EP 687265, WO 9420495
-
Sauerberg, P., Olesen, P.H., Mich, C.H. (Novo Nordisk A/S). Heterocyclic cpds. and their preparation and use. EP 687265, WO 9420495.
-
-
-
Sauerberg, P.1
Olesen, P.H.2
Mich, C.H..3
-
3
-
-
10544255532
-
-
Piperidine cpds. and their preparation and use. EP 384288, US 5260311, US 5264444, US 5284859, US 5328925
-
Sauerberg, P., Olesen, P.H. (Novo Nordisk A/S). Piperidine cpds. and their preparation and use. EP 384288, US 5260311, US 5264444, US 5284859, US 5328925.
-
-
-
Sauerberg, P.1
Olesen, P.H..2
-
4
-
-
10544227526
-
-
Heterocyclic chemistry. WO 9429303
-
Osborne, L.M., Shipley, L.A., Treppendahl, S., Petersen, T.G. (Novo Nordisk A/S). Heterocyclic chemistry. WO 9429303.
-
-
-
Osborne, L.M.1
Shipley, L.A.2
Treppendahl, S.3
Petersen, T.G..4
-
5
-
-
0022645755
-
The cholinergic hypothesis - Ten years on
-
Perry, E.K. The cholinergic hypothesis - Ten years on. Brit Med Bull 1986, 42: 63-9.
-
(1986)
Brit Med Bull
, vol.42
, pp. 63-69
-
-
Perry, E.K.1
-
6
-
-
0020657372
-
Presynaptic cholinergic dysfunctions in patients with dementia
-
Sims, N.R., Bowen, D.M., Smith, C.C.T., Neary, D., Thomas, D.J., Davison, A.N. Presynaptic cholinergic dysfunctions in patients with dementia. J Neurochem 1983, 40: 503-9.
-
(1983)
J Neurochem
, vol.40
, pp. 503-509
-
-
Sims, N.R.1
Bowen, D.M.2
Smith, C.C.T.3
Neary, D.4
Thomas, D.J.5
Davison, A.N.6
-
7
-
-
0023949333
-
Acetylcholine and Alzheimer's disease
-
Perry, E.K. Acetylcholine and Alzheimer's disease. Brit J Psychiatry 1988, 152: 737-40.
-
(1988)
Brit J Psychiatry
, vol.152
, pp. 737-740
-
-
Perry, E.K.1
-
10
-
-
0026702873
-
1 selective muscarinic agonist hexyloxy-TZTP
-
1 selective muscarinic agonist hexyloxy-TZTP. Bioorg Med Chem Lett 1992, 2: 809-14.
-
(1992)
Bioorg Med Chem Lett
, vol.2
, pp. 809-814
-
-
Sauerberg, P.1
Olesen, P.H.2
Suzdak, P.D.3
Sheardown, M.J.4
Mitch, C.H.5
Quimby, S.J.6
Ward, J.S.7
Bymaster, F.P.8
Sawyer, B.D.9
Shannon, H.E.10
-
11
-
-
0027938808
-
1 selective muscarinic receptor agonist xanomeline
-
1 selective muscarinic receptor agonist xanomeline. Bioorg Med Chem Lett 1994, 4: 2205-10.
-
(1994)
Bioorg Med Chem Lett
, vol.4
, pp. 2205-2210
-
-
Quimby, S.J.1
Shannon, H.E.2
Bymaster, F.P.3
Sauerberg, P.4
Olesen, P.H.5
Sheardown, M.J.6
Suzdak, P.D.7
Mitch, C.H.8
-
12
-
-
0026656274
-
Steric and electronic requirements for muscarinic receptor-stimulated phosphoinositide turnover in the CNS in a series of arecoline bioisosteres
-
Ngur, D., Roknich, S., Mitch, C.H., Quimby, S.J., Ward, J.S., Merritt, L., Sauerberg, P., Messer, W.S. Jr., Hoss, W. Steric and electronic requirements for muscarinic receptor-stimulated phosphoinositide turnover in the CNS in a series of arecoline bioisosteres. Biochem Biophys Res Commun 1992, 187: 1389-94.
-
(1992)
Biochem Biophys Res Commun
, vol.187
, pp. 1389-1394
-
-
Ngur, D.1
Roknich, S.2
Mitch, C.H.3
Quimby, S.J.4
Ward, J.S.5
Merritt, L.6
Sauerberg, P.7
Messer Jr., W.S.8
Hoss, W.9
-
15
-
-
10544246261
-
1 receptor agonist - Preclinical update
-
E. Giacobini and R. Becker (Eds.), Birkhauser, Boston
-
1 receptor agonist - Preclinical update. In: Alzheimer Disease. Therapeutic Strategies. Advances in Alzheimer Disease Therapy, E. Giacobini and R. Becker (Eds.), Birkhauser, Boston, 1994, 229-33.
-
(1994)
Alzheimer Disease. Therapeutic Strategies. Advances in Alzheimer Disease Therapy
, pp. 229-233
-
-
Shannon, H.E.1
Bymaster, F.P.2
Calligaro, D.O.3
-
16
-
-
0345353530
-
Tacrine, but not RS86 or xanomeline, attenuate delay-induced deficits in the rat T-maze
-
Abst 49
-
Davey, P.T., East, S.Z., Rogers, D.C. Tacrine, but not RS86 or xanomeline, attenuate delay-induced deficits in the rat T-maze. J Psychopharmacol 1995, 9(3, Suppl.): Abst 49.
-
(1995)
J Psychopharmacol
, vol.9
, Issue.3 SUPPL.
-
-
Davey, P.T.1
East, S.Z.2
Rogers, D.C.3
-
17
-
-
10544253279
-
Muscarinic agonists increase hippocampal phosphatidyl inositol turnover in vivo and attenuate hemicholinium-3-induced amnesia in mice
-
Abst 773.7
-
Ward, K.M., Chapin, D.S., Nowakowski, J.T., Forman, J.T., Nason, D.M., Villalobos, A., Liston, D.R. Muscarinic agonists increase hippocampal phosphatidyl inositol turnover in vivo and attenuate hemicholinium-3-induced amnesia in mice. Soc Neurosci Abst 1995, 21(1-3): Abst 773.7.
-
(1995)
Soc Neurosci Abst
, vol.21
, Issue.1-3
-
-
Ward, K.M.1
Chapin, D.S.2
Nowakowski, J.T.3
Forman, J.T.4
Nason, D.M.5
Villalobos, A.6
Liston, D.R.7
-
18
-
-
10544252864
-
Absorption, distribution, metabolism, and elimination of radiolabeled xanomeline in healthy male subjects
-
Abst P-117-14
-
DeLong, A.F., Bonate, P.L., Gillespie, T., Henry, D.P., Satterwhite, J.H., Henry, D.P. Absorption, distribution, metabolism, and elimination of radiolabeled xanomeline in healthy male subjects. Neuropsychopharmacology 1994, 10(3S, Part 2): Abst P-117-14.
-
(1994)
Neuropsychopharmacology
, vol.10
, Issue.3 S AND PART 2
-
-
DeLong, A.F.1
Bonate, P.L.2
Gillespie, T.3
Henry, D.P.4
Satterwhite, J.H.5
Henry, D.P.6
-
20
-
-
0041868571
-
Differences in the metabolism of xanomeline, a candidate drug in the treatment of Alzheimer's disease, in rat and monkey via oral and subcutaneous administration
-
(Aug 27-31, Seattle) Abst 271
-
Shipley, L.A., Cornpropst, J.D., Skaggs, T.G., Brown, T.J., Lindsay, T.J., Gillespie, T.A. Differences in the metabolism of xanomeline, a candidate drug in the treatment of Alzheimer's disease, in rat and monkey via oral and subcutaneous administration. 4th Int ISSX Meet (Aug 27-31, Seattle) 1995, Abst 271.
-
(1995)
4th Int ISSX Meet
-
-
Shipley, L.A.1
Cornpropst, J.D.2
Skaggs, T.G.3
Brown, T.J.4
Lindsay, T.J.5
Gillespie, T.A.6
-
21
-
-
0027475738
-
1 agonist, LY246708, an investigational agent with potential for the treatment of Alzheimer's disease, in human plasma
-
1 agonist, LY246708, an investigational agent with potential for the treatment of Alzheimer's disease, in human plasma. J Chromatogr-Biomed Appl 1993, 613: 365-70.
-
(1993)
J Chromatogr-Biomed Appl
, vol.613
, pp. 365-370
-
-
Hamilton, C.L.1
Kirkwood, J.A.2
Carter, G.3
Williams, R.S.4
-
23
-
-
0028915398
-
Determination of xanomeline (LY246708 tartrate), an investigational agent for the treatment of Alzheimer's disease, in rat and monkey plasma by capillary gas chromatography with nitrogen-phosphorus detection
-
Brown, T.J., Shipley, L.A. Determination of xanomeline (LY246708 tartrate), an investigational agent for the treatment of Alzheimer's disease, in rat and monkey plasma by capillary gas chromatography with nitrogen-phosphorus detection. J Chromatogr B-Biomed Appl 1995, 665: 337-44.
-
(1995)
J Chromatogr B-Biomed Appl
, vol.665
, pp. 337-344
-
-
Brown, T.J.1
Shipley, L.A.2
-
24
-
-
1542476885
-
Analysis of xanomeline, a potential drug for Alzheimer's disease, by electrospray ionization tandem mass spectrometry
-
Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry
-
Gillespie, T.A., Lindsay, T.J., Cornpropst, J.D., Bonate, P.L., Skaggs, T.G., DeLong, A.F., Shipley, L.A. Analysis of xanomeline, a potential drug for Alzheimer's disease, by electrospray ionization tandem mass spectrometry. ACS Symp Ser 1996, 619(Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry): 315-29.
-
ACS Symp Ser 1996
, vol.619
, pp. 315-329
-
-
Gillespie, T.A.1
Lindsay, T.J.2
Cornpropst, J.D.3
Bonate, P.L.4
Skaggs, T.G.5
DeLong, A.F.6
Shipley, L.A.7
-
26
-
-
10544237450
-
1-specific cholinergic agonist, in patients with Alzheimer's disease
-
Abst P-117-15
-
1-specific cholinergic agonist, in patients with Alzheimer's disease. Neuropsychopharmacology 1994, 10(3S, Part 2): Abst P-117-15.
-
(1994)
Neuropsychopharmacology
, vol.10
, Issue.3 S AND PART 2
-
-
Cutler, N.R.1
Sramek, J.J.2
Seifert, R.D.3
Conrad, J.J.4
Wardle, T.S.5
Dies, F.6
Hurley, D.J.7
Thoren, L.M.8
-
27
-
-
0029081632
-
The safety and tolerance of xanomeline tartrate in patients with Alzheimer's disease
-
Sramek, J.J., Hurley, D.J., Wardle, T.S., Satterwhite, J.H., Hourani, J., Dies, F., Cutler, N.R. The safety and tolerance of xanomeline tartrate in patients with Alzheimer's disease. J Clin Pharmacol 1995, 35: 800-6.
-
(1995)
J Clin Pharmacol
, vol.35
, pp. 800-806
-
-
Sramek, J.J.1
Hurley, D.J.2
Wardle, T.S.3
Satterwhite, J.H.4
Hourani, J.5
Dies, F.6
Cutler, N.R.7
-
28
-
-
8244239544
-
1 agonist in mild and moderate Alzheimer's disease
-
Abst S-16-4
-
1 agonist in mild and moderate Alzheimer's disease. Eur Neuropsychopharmacol 1995, 5(3): Abst S-16-4.
-
(1995)
Eur Neuropsychopharmacol
, vol.5
, Issue.3
-
-
Bodick, N.C.1
Offen, W.2
-
30
-
-
7144251729
-
1-selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of patients with mild to moderate Alzheimer's disease
-
(July 24-29, Osaka) Abst 557
-
1-selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of patients with mild to moderate Alzheimer's disease. 5th Int Conf Alzheimer's Dis Relat Disord (July 24-29, Osaka) 1996, Abst 557.
-
(1996)
5th Int Conf Alzheimer's Dis Relat Disord
-
-
Bodick, N.1
Offen, W.2
-
31
-
-
10544250054
-
1 muscarinic agonist xanomeline improves both cognitive and behavioral deficits in Alzheimer's disease
-
Abst O-20-4
-
1 muscarinic agonist xanomeline improves both cognitive and behavioral deficits in Alzheimer's disease. Eur Neuropsychopharmacol 1996, 6(Suppl. 3): Abst O-20-4.
-
(1996)
Eur Neuropsychopharmacol
, vol.6
, Issue.3 SUPPL.
-
-
Bodick, N.1
Offen, W.2
-
35
-
-
10544245879
-
-
Antipsychotic method. WO 9505174
-
Bymaster, F.P., Shannon, H.E. (Novo Nordisk A/S). Antipsychotic method. WO 9505174.
-
-
-
Bymaster, F.P.1
Shannon, H.E..2
-
36
-
-
10544233980
-
-
A method of treating gastrointestinal motility disorders. WO 9517185
-
Greenwood, B. (Novo Nordisk A/S). A method of treating gastrointestinal motility disorders. WO 9517185.
-
-
-
Greenwood, B..1
-
37
-
-
10544233955
-
11C-TZTP derivatives for the visualization of muscarinic receptors in the human brain in vivo
-
April 10-14, Nice
-
11C-TZTP derivatives for the visualization of muscarinic receptors in the human brain in vivo. 4th Int Nice/Springfield Symp Adv Alzheimer Ther (April 10-14, Nice) 1996, 72.
-
(1996)
4th Int Nice/Springfield Symp Adv Alzheimer Ther
, pp. 72
-
-
Nybäck, H.1
Farde, L.2
Halldin, C.3
Karlsson, P.4
Nakashima, Y.5
Bymaster, F.P.6
Shannon, H.E.7
Sauerberg, P.8
-
38
-
-
10544237088
-
The effects of muscarinic agonist xanomeline on human sleep
-
Abst 432
-
Lucas, R., Idzikowski, C. The effects of muscarinic agonist xanomeline on human sleep. Neurobiol Aging 1994, 15(Suppl. 1): Abst 432.
-
(1994)
Neurobiol Aging
, vol.15
, Issue.1 SUPPL.
-
-
Lucas, R.1
Idzikowski, C.2
-
39
-
-
10544240175
-
Plasma amyloid β protein (Aβ) in patients with probable Alzheimer's disease (AD): Relationship to cholinomimetic therapy
-
(July 24-29, Osaka) Abst 287
-
Pomara, N., Tun, H., Bernstein, S., Imbimbo, B.P. Plasma amyloid β protein (Aβ) in patients with probable Alzheimer's disease (AD): Relationship to cholinomimetic therapy. 5th Int Conf Alzheimer's Dis Relat Disord (July 24-29, Osaka) 1996, Abst 287.
-
(1996)
5th Int Conf Alzheimer's Dis Relat Disord
-
-
Pomara, N.1
Tun, H.2
Bernstein, S.3
Imbimbo, B.P.4
-
45
-
-
0342752894
-
A bridging study of xanomeline tartrate in Alzheimer's disease (AD)
-
Abst 49
-
Cutler, N.R., Sramek, J.J., Seifert, R.D., Conrad, J.J., Wardle, T.S., Hurley, D.J., Thoren, L.M. A bridging study of xanomeline tartrate in Alzheimer's disease (AD). Biol Psychiatry 1994, 35(9): Abst 49.
-
(1994)
Biol Psychiatry
, vol.35
, Issue.9
-
-
Cutler, N.R.1
Sramek, J.J.2
Seifert, R.D.3
Conrad, J.J.4
Wardle, T.S.5
Hurley, D.J.6
Thoren, L.M.7
-
46
-
-
10544246231
-
1-specific cholinergic agonist, in patients with Alzheimer's disease
-
Abst 428
-
1-specific cholinergic agonist, in patients with Alzheimer's disease. Neurobiol Aging 1994, 15(Suppl. 1): Abst 428.
-
(1994)
Neurobiol Aging
, vol.15
, Issue.1 SUPPL.
-
-
Cutler, N.R.1
Sramek, J.J.2
Seifert, R.D.3
Conrad, J.J.4
Wardle, T.S.5
-
48
-
-
10544232058
-
Absorption, distribution, metabolism, and elimination of radiolabeled xanomeline in healthy male subjects
-
Abst 431
-
DeLong, A.F., Bonate, P.L., Gillespie, T., Henry, D.P., Satterwhite, J.H. Absorption, distribution, metabolism, and elimination of radiolabeled xanomeline in healthy male subjects. Neurobiol Aging 1994, 15(Suppl. 1): Abst 431.
-
(1994)
Neurobiol Aging
, vol.15
, Issue.1 SUPPL.
-
-
DeLong, A.F.1
Bonate, P.L.2
Gillespie, T.3
Henry, D.P.4
Satterwhite, J.H.5
-
49
-
-
10544244791
-
1 agonist: Early clinical study
-
May 11-15, Springfield
-
1 agonist: Early clinical study. 3rd Int Springfield Symp Adv Alzheimer Ther (May 11-15, Springfield) 1994, 77.
-
(1994)
3rd Int Springfield Symp Adv Alzheimer Ther
, pp. 77
-
-
Bodick, N.1
DeLong, A.2
Henry, D.3
Lucas, R.4
Satterwhite, J.5
Farde, L.6
Cutler, N.7
-
50
-
-
0006475412
-
1-specific cholinergic agonist, in patients with Alzheimer's disease
-
Abst PII-86
-
1-specific cholinergic agonist, in patients with Alzheimer's disease. Clin Pharmacol Ther 1994, 55(2): Abst PII-86.
-
(1994)
Clin Pharmacol Ther
, vol.55
, Issue.2
-
-
Sramek, J.J.1
Cutler, N.R.2
Seifert, R.D.3
Conrad, J.J.4
Wardle, T.S.5
Hurley, D.J.6
Thoren, L.M.7
-
52
-
-
0342752895
-
1 agonist: Early clinical studies
-
E. Giacobini and R. Becker (Eds.), Birkhauser, Boston
-
1 agonist: Early clinical studies. In: Alzheimer Disease. Therapeutic Strategies. Advances in Alzheimer Disease Therapy, E. Giacobini and R. Becker (Eds.), Birkhauser, Boston, 1994, 234-8.
-
(1994)
Alzheimer Disease. Therapeutic Strategies. Advances in Alzheimer Disease Therapy
, pp. 234-238
-
-
Bodick, N.C.1
DeLong, A.F.2
Bonate, P.L.3
-
53
-
-
10544230408
-
1 agonist for the treatment of Alzheimer's disease
-
Abst S-206-867
-
1 agonist for the treatment of Alzheimer's disease. Neuropsychopharmacology 1994, 10(3S, Part 1): Abst S-206-867.
-
(1994)
Neuropsychopharmacology
, vol.10
, Issue.3 S AND PART 1
-
-
Bodick, N.1
-
54
-
-
10544229530
-
Absorption, distribution, metabolism, and elimination of radiolabeled xanomeline in healthy male subjects
-
Alzheimer's and Parkinson's Diseases
-
DeLong, A.F., Bonate, P.L., Gillespie, T., Henry, D.P., Satterwhite, J.H. Absorption, distribution, metabolism, and elimination of radiolabeled xanomeline in healthy male subjects. Adv Behav Biol 1995, 44(Alzheimer's and Parkinson's Diseases): 463-8.
-
(1995)
Adv Behav Biol
, vol.44
, pp. 463-468
-
-
DeLong, A.F.1
Bonate, P.L.2
Gillespie, T.3
Henry, D.P.4
Satterwhite, J.H.5
-
55
-
-
10544242712
-
1-specific cholinergic agonist, in patients with Alzheimer's disease
-
(May 11-15, Springfield) Abst P33
-
1-specific cholinergic agonist, in patients with Alzheimer's disease. 3rd Int Springfield Symp Adv Alzheimer Ther (May 11-15, Springfield) 1994, Abst P33.
-
(1994)
3rd Int Springfield Symp Adv Alzheimer Ther
-
-
Cutler, N.R.1
Sramek, J.J.2
Seifert, R.D.3
Conrad, J.J.4
Wardle, T.S.5
Dies, F.6
Hurley, D.J.7
Thoren, L.M.8
-
56
-
-
10544243130
-
Absorption, distribution, metabolism, and elimination of radiolabeled xanomeline in healthy male subjects
-
(May 11-15, Springfield) Abst P34
-
DeLong, A.F., Bonate, P.L., Gillespie, T, Henry, D.P., Satterwhite, J.H. Absorption, distribution, metabolism, and elimination of radiolabeled xanomeline in healthy male subjects. 3rd Int Springfield Symp Adv Alzheimer Ther (May 11-15, Springfield) 1994, Abst P34.
-
(1994)
3rd Int Springfield Symp Adv Alzheimer Ther
-
-
DeLong, A.F.1
Bonate, P.L.2
Gillespie, T.3
Henry, D.P.4
Satterwhite, J.H.5
-
61
-
-
10544247561
-
New radioligands for PET-examination of central muscarinic receptors
-
Abst 433
-
Farde, L., Suhara, T., Halldin, C., Karlsson, P., Nybäck, H. New radioligands for PET-examination of central muscarinic receptors. Neurobiol Aging 1994, 15(Suppl. 1): Abst 433.
-
(1994)
Neurobiol Aging
, vol.15
, Issue.1 SUPPL.
-
-
Farde, L.1
Suhara, T.2
Halldin, C.3
Karlsson, P.4
Nybäck, H.5
-
65
-
-
10544255509
-
New radioligands for PET-examination of central muscarinic receptors
-
Abst P-117-12
-
Farde, L., Suhara, T., Halldin, C., Karlsson, P., Nybäck, H., Müller, L., Foged, C., Sauerberg, P., Lucas, R. New radioligands for PET-examination of central muscarinic receptors. Neuropsychopharmacology 1994, 10(3S, Part 2): Abst P-117-12.
-
(1994)
Neuropsychopharmacology
, vol.10
, Issue.3 S AND PART 2
-
-
Farde, L.1
Suhara, T.2
Halldin, C.3
Karlsson, P.4
Nybäck, H.5
Müller, L.6
Foged, C.7
Sauerberg, P.8
Lucas, R.9
-
70
-
-
34347278624
-
1 receptor agonist for Alzheimer's disease
-
Abst SAT-5-2
-
1 receptor agonist for Alzheimer's disease. Eur Neuropsychopharmacol 1995, 5(3): Abst SAT-5-2.
-
(1995)
Eur Neuropsychopharmacol
, vol.5
, Issue.3
-
-
Shannon, H.E.1
Bymaster, F.P.2
Calligaro, D.O.3
DeLapp, N.W.4
Mitch, C.H.5
Ward, J.S.6
Olesen, P.7
Sheardown, M.J.8
Swedberg, M.D.B.9
Sauerberg, P.10
|