Accumulation of glycolipids in mutant Chinese hamster ovary cells (Z65) with defective peroxisomal assembly and comparison of the metabolic rate of glycosphingolipids between Z65 cells and wild-type CHO-K1 cells

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1438, Issue 1, 1999, Pages 55-62

  Saito, Makiko ^a   Iwamori, Masao ^b   Lin, Bei ^a   Oka, Akira ^c   Fujiki, Yukio ^d   Shimozawa, Nobuyuki ^e   Kamoshita, Shigehiko ^f   Yanagisawa, Masayoshi ^a   Sakakihara, Yoichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e GIFU UNIVERSITY   (Japan)

^f NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

CHO mutant; Glycolipid; Peroxisome; Zellweger syndrome

Indexed keywords

CERAMIDE; CHOLESTEROL; FATTY ACID; GANGLIOSIDE; GLYCEROPHOSPHOLIPID; GLYCOLIPID; LONG CHAIN FATTY ACID; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; SPHINGOMYELIN; TRIACYLGLYCEROL;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL INCLUSION; CELL MIGRATION; CELL PROLIFERATION; CHINESE HAMSTER; CONTROLLED STUDY; DISORDERS OF PEROXISOMAL FUNCTIONS; FATTY ACID OXIDATION; FEMALE; LIPID COMPOSITION; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; METABOLIC RATE; NONHUMAN; OVARY CELL; PEROXISOME; PRIORITY JOURNAL;

ANIMALS; CHO CELLS; CRICETINAE; GLYCOLIPIDS; GLYCOSPHINGOLIPIDS; MUTATION; PEROXISOMAL DISORDERS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0033583582     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(99)00037-2     Document Type: Article

References (32)

1. P.B. Lazarow, H.W. Moser, Disorders of Peroxisomal Biogenesis, in: C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds.), The Metabolic and Molecular Basis of Inherited Diseases, McGraw-Hill, New York, 1995, pp. 2287-2324.
2. Tsukamoto T., Miura S., Fujiki Y. Restoration by a 35K membrane protein of peroxisome assembly in a peroxisome-deficient mammalian cell mutant. Nature. 350:1991;77-81.
3. Shimozawa N., Tsukamoto T., Suzuki Y., Orii T., Shirayoshi Y., Mori T., Fujiki Y. A human gene responsible for Zellweger syndrome that affects peroxisome assembly. Science. 255:1992;1132-1134.
4. Shimozawa N., Suzuki Y., Tomatsu S., Tsukamoto T., Osumi T., Fujiki Y., Kamijo K., Hashimoto T., Kondo N., Orii T. Correction by gene expression of biochemical abnormalities in fibroblasts from Zellweger patients. Pediatr. Res. 39:1996;812-815.
5. Fukuda S., Shimozawa N., Suzuki Y., Zhang Z., Tomatsu S., Tsukamoto T., Hashiguchi N., Osumi T., Masuno M., Imaizumi K., Kuroki Y., Fujiki Y., Orii T., Kondo N. Human peroxisome assembly factor-2 (PAF-2): a gene responsible for group C peroxisome biogenesis disorder in humans. Am. J. Hum. Genet. 59:1996;1210-1220.
6. Schtugens R.B.H., Heymans H.S.A., Wanders R.J.A., Van der Bosch H., Tager J.M. Peroxisomal disorders: a newly recognized group of genetic diseases. Eur. J. Pediatr. 144:1986;430-440.
7. Volpe J.J., Adams R.D. Cerebro-hepato-renal syndrome of Zellweger: An inherited disorder of neuronal migration. Acta Neuropathol. 20:1972;175-198.
8. Evrard P., Caviness V.S. Jr., Prats-Vinas J., Lyon G. The mechanism of arrest of neuronal migration in the Zellweger malformation: an hypothesis based upon cytoarchitectonic analysis. Acta Neuropathol. 41:1978;109-117.
9. Powers J.M., Moser H.W., Moser A.B., Upsur J.K., Bradford B.F., Pai S.G., Kohn P.H., Frias J., Tiffany C. Fetal cerebrohepatorenal (Zellweger) syndrome: dysmorphic, radiologic, biochemical, and pathologic findings in four affected fetuses. Hum. Pathol. 16:1985;610-620.
10. Powers J.M. The pathology of peroxisomal disorders with pathogenetic considerations. J. Neuropathol. Exp. Neurol. 54:1995;710-719.
11. Saito M., Iimori Y., Kamoshita S., Yanagisawa M., Sakakihara Y. Effects of perxosiomal β-oxidation antagonist on 2′,3′-cyclic-nucleotide 3′-phosphohydrase, membrane lipid compositions, and membrane fluidity in C-6 glial cells. Biochim. Biophys. Acta. 1235:1995;178-182.
12. Tsukamoto T., Yokota S., Fujiki Y. Isolation and characterization of Chinese hamster ovary cell mutants defective in assembly of peroxisomes. J. Cell. Biol. 110:1990;651-660.
13. Macgee J., Allen K.G. Preparation of methyl esters from the saponifiable fatty acids in small biological specimens for gas-liquid chromatographic analysis. J. Chromatogr. 100:1974;35-42.
14. Bartllet G.R. Phosphorus assay in column chromatography. J. Biol. Chem. 234:1959;466-468.
15. Y. Kishimoto, M. Hoshi, in: R. Freid (Ed.), Methods in Neurochemistry, Vol. 3, Marcel Dekker, New York, 1972, pp. 95-153.
16. Iwamori M., Sawada K., Hara Y., Nishino M., Fujisawa T., Imura H., Nagai Y. Neutral glycosphingolipids and gangliosides of bovine thyroid. J. Biochem. 91:1982;1875-1887.
17. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
18. Infante J.P., Huszagh V.A. On the molecular etiology of decresed arachdonic (20:4n-6), docosapentanoic (22:5n-6) and docosahexanoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders. Mol. Cell. Biochem. 168:1997;101-115.
19. Hannum Y.A., Bell R.M. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science. 243:1989;500-507.
20. Hakomori S.I. Bifunctional role of glycosphingolipids. J. Biol. Chem. 265:1990;18713-18716.
21. R.W. Ledeen, in: R.J. Margolis, R.K. Margolis (Eds.), Neurobiology of Glycoconjugates, Plenum Press, New York, 1989, p. 43.
22. Svennerholm L., Rynmark B.-M., Vilbergsson G., Fredman P., Gottfries J., Mansson J.-E., Percy A. Gangliosides in human fetal brain. J. Neurochem. 56:1991;1763-1768.
23. Schwarz A., Futerman A.H. Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth. J. Neurosci. 17:1997;2929-2938.
24. Uemura K., Sugiyama E., Taketomi T. Effects of an inhibitor of glucosylceramide synthase on glycosphingolipid synthesis and neurite outgrowth in murine neuroblastoma cell lines. J. Biochem. 110:1991;96-102.
25. Harel R., Faterman H. Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons. J. Biol. Chem. 268:1993;14476-14481.
26. Huang J.-Q., Trasler J.M., Igdoura S., Michaud J., Hanai N., Gravel R.A. Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases. Hum. Mol. Genet. 6:1997;1879-1885.
27. Hitoshi S., Kojima N., Kusunoki S., Inokuchi J., Kanazawa I., Tsuji S. Expression of the β-galactoside α1,2-fucosyltransferase gene suppresses axonal outgrowth of neuro2a neuroblastoma cells. J. Neurochem. 66:1996;1633-1640.
28. Merrill A.H. Jr., Jones D.D. An update of the enzymology and regulation of sphingomyelin metabolism. Biochim. Biophys. Acta. 1044:1990;1-12.
29. J.N. Kanfer, in: C.J. Hanahan (Ed.), Handbook of Lipid Research, Vol. 3, Plenum Press, New York, 1983, pp. 167-247.
30. Y. Kishimoto, in: P.D. Boyer (Ed.), The Enzymes, Vol. 11, Academic Press, Orlando, FL, 1983, pp. 357-407.
31. Rother J., van Ecthen G., Schwarzmann G., Sandhoff K. Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells. Biochem. Biophys. Res. Commun. 189:1992;14-20.
32. Ichikawa S., Sakiyama H., Suzuki G., Hidari I.P.J.K., Hirabayashi Y. Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis. Proc. Natl. Acad. Sci. USA. 93:1996;4638-4643.