Synthesis, structural characterization and antitumor activity evaluations of copper complex with tetraazamacrocyclic ligand

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 8, 1999, Pages 1087-1092

  Kong, Deyuan ^a   Qin, Chen ^a   Meng, Linhua ^a   Xie, Yuyuan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,7,10 TETRAKIS(2 CYANOETHYL) 1,4,7,10 TETRAAZACYCLODODECANE; COPPER COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DNA CLEAVAGE; DRUG STRUCTURE; SYNTHESIS; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; COPPER; DNA, SUPERHELICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; K562 CELLS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; ORGANOMETALLIC COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 0033583528     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00139-0     Document Type: Article

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22. 3. Z=1, R=0.063, Rw=0.067, GOF=1.70. The data were collected on a Rigaku AFC 7R diffractometer at 293K. The structure was solved by direct methods and expanded using Fourier techniques. The data were corrected for Lorenz and polarization effects. Atomic coordinates, bond angles, bond lengths and thermal parameters assisted to this complex have been deposited at the Cambridge Crystallographic Data Center in CIF file. CCDC number: 112691.