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note
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2 was chosen as the optimal solvent for the reactions with 3 based on lower overall conversion obtained in benzene. When the reaction was carried out at room temperature, the RCM of substrate 2a was slower and the overall conversion of 2a into 5a after 15 h did not go beyond 38%.
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18
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0344455909
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note
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The NMR analysis of the crude mixtures show only the desired cyclized product and the starting material with no side products. No trace of dimers was detected.
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20
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0001077422
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