Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 20, 1999, Pages 3057-3060

  Ohyama, Masayoshi ^a   Tanaka, Toshiyuki ^b   Ito, Tetsuro ^b   Iinuma, Munekazu ^b   Bastow, Kenneth F ^a   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Gifu Prefectural Institute of Health and Environmental Sciences   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; AMPELOPSIN; HOPEAPHENOL; OLIGOMER; PALLIDOL HEXAACETATE; PHENOL DERIVATIVE; RESVERATROL; UNCLASSIFIED DRUG;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; CYTOTOXICITY TEST; DRUG DOSE; DRUG SCREENING; HUMAN; HUMAN CELL; TUMOR CELL LINE;

ACETATES; BIOPOLYMERS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; STILBENES; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0033581561     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00520-X     Document Type: Article

References (16)

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15. 3): (-)-Ampelopsin A hexaacetate (1a): δ 2.03 (3H, s), 2.27 (6H, s), 2.29 (9H, s), 4.24 (1H, d, J = 10 Hz), 5.26 (1H, d, J = 5 Hz), 5.97 (1H, d, J = 10 Hz), 6.56 (1H, d, J = 2 Hz), 6.68 (1H, d, J = 5 Hz), 6.76 (1H, d, J = 2 Hz), 6.79 (1H, br s), 7.05 (2H, d, J = 8 Hz), 7.08 (2H, d, J = 8 Hz), 7.22 (2H, d, J = 8 Hz); Pallidol hexaacetate (2a): δ 1.69 (6H, s), 2.28 (6H, s), 2.30 (6H, s), 4.17 (2H, t like m), 4.44 (2H, t like m), 6.76 (2H, d, J = 2 Hz), 6.88 (2H, d, J = 2 Hz), 7.05 (4H, d, J = 9 Hz), 7.16 (2H, d, J = 9 Hz); Isoampelopsin F hexaacetate (3a): δ 1.56, 2.14, 2.25, 2.26, 2.30, 2.36 (3H each, s), 3.58 (1H, d, J = 6 Hz), 3.89 (1H, s), 4.18 (1H, s), 4.70 (1H, d, J = 6 Hz), 5.74 (1H, d, J = 2 Hz), 5.80 (1H, dd, J = 8, 2 Hz), 6.68 (1H, dd, J = 8, 2 Hz), 6.75 (1H, d, J = 2 Hz), 6.78 (1H, d, J = 2 Hz), 6.92 (2H, d, J = 8 Hz), 7.10 (2H, d, J = 8 Hz), 7.40 (1H, dd, J = 8, 2 Hz); ε-Viniferin pentaacetate (4a): δ 2.27 (9H, s), 2.30, 2.34 (3H each, s), 4.60 (1H, d, J = 7 Hz), 5.60 (1H, d, J = 7 Hz), 6.53 (1H, d, J = 15 Hz), 6.65 (1H, d, J = 2 Hz), 6.85 (2H, d, J = 2 Hz), 6.92 (1H, d, J = 15 Hz), 6.98 (2H, d, J = 9 Hz), 7.10 (2H, d, J = 9 Hz), 7.18 (2H, d, J = 9 Hz), 7.34 (2H, d, J = 9 Hz); Gnetin E heptaacetate (5a): δ 1.77 (3H, s), 1.92 (3H, d, J = 5 Hz), 2.27 (6H, s), 2.31 (9H, s), 4.49 (2H, m), 5.53 (1H, dd, J = 9, 2 Hz), 5.66 (1H, dd, J = 8, 2 Hz), 6.47 (1H, d, J = 3 Hz), 6.68 (1H, br s), 6.76 (2H, d, J = 2 Hz), 6.80 (1H, d, J = 2 Hz), 6.88 (1H, d, J = 2 Hz), 7.02 (1H, d, J = 3 Hz), 7.11 (10H, m), 7.31 (2H, dd, J = 8, 2 Hz), 7.40 (2H, dd, J = 8, 2 Hz), 7.52 (2H, d, J = 8 Hz); Hopeaphenol decaacetate (10a): δ 1.89, 2.13, 2.26, 2.29, 2.30 (6H each, s), 4.07 (2H, br s), 4.19 (2H, d, J = 10 Hz), 4.94 (2H, d, J = 2 Hz), 5.12 (2H, br s), 6.00 (2H, d, J = 10 Hz), 6.13 (2H, d, J = 2 Hz), 6.88 (4H, d, J = 8 Hz), 6.92 (2H, br s), 7.07 (4H, d, J = 8 Hz), 7.08 (4H, d, J = 8 Hz), 7.13 (2H, d, J = 2 Hz), 7.23 (4H, d, J = 8 Hz).
16. Rubinstein, L. V; Shoemaker, R. H.; Paull, K. D.; Simo, R. M.; Tosini, S.; Skehan, P.; Scudiero, P. A.; Monks, A.; Boyd, M. R. J. Natl.cancer Inst. 1990, 82, 1113.