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Volumn 9, Issue 20, 1999, Pages 2969-2972

Structure and antimalarial activity of adducts of 11-azaartemisinin with conjugated terminal acetylenes

Author keywords

[No Author keywords available]

Indexed keywords

11 AZARTEMISININ; 11 AZARTEMISININ 2A; 11 AZARTEMISININ 3A; 11 AZARTEMISININ 3B; 11 AZARTEMISININ 3C; ACETYLENE DERIVATIVE; ARTEMISININ DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0033581556     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00506-5     Document Type: Article
Times cited : (18)

References (13)
  • 10
    • 0009517346 scopus 로고    scopus 로고
    • Purchased from Lancaster Synthesis Inc.
    • Purchased from Lancaster Synthesis Inc.
    • Tetrahedron Lett.
  • 12
    • 0009547334 scopus 로고    scopus 로고
    • Typical experimental procedure: To a solution of 2a (27 mg, 0.1 mmol) in anhydrous acetonitrile (2 mL) were added at room temperature DMAP (20 mg) and methyl propiolate (30 mg, 0.36 mmol). Color developed immediately (yellow to red). After 15∼20 min at room temperature, an examination of the reaction by thin layer revealed that 2a had completely disappeared and a less polar product had formed. The reaction mixture was concentrated on a rotovap and the residue purified by column chromatography on silica gel
    • Typical experimental procedure: To a solution of 2a (27 mg, 0.1 mmol) in anhydrous acetonitrile (2 mL) were added at room temperature DMAP (20 mg) and methyl propiolate (30 mg, 0.36 mmol). Color developed immediately (yellow to red). After 15∼20 min at room temperature, an examination of the reaction by thin layer revealed that 2a had completely disappeared and a less polar product had formed. The reaction mixture was concentrated on a rotovap and the residue purified by column chromatography on silica gel.
    • J. Org. Chem.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.