A selective retinoid with high activity against an androgen-resistant prostate cancer cell type

International Journal of Cancer

Volumn 80, Issue 2, 1999, Pages 272-278

  Lu, Xian Ping ^a,c   Fanjul, Andrea ^a,b   Picard, Nathalie ^a,d   Shroot, Braham ^c,d   Pfahl, Magnus ^a,b  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

^b MAXIA Pharmaceuticals Inc   (United States)

^c Galderma Research Inc   (United States)

^d Galderma R and D   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; RETINOIC ACID DERIVATIVE; RETINOID;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; TREATMENT FAILURE; TREATMENT INDICATION;

ANDROGENS; APOPTOSIS; CELL DIVISION; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; PROSTATIC NEOPLASMS; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0033579930     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990118)80:2<272::AID-IJC17>3.0.CO;2-X     Document Type: Article

References (32)

1. BOYLAN, J.F., LOHNES, D., TANEJA, R., CHAMBON, P. and GUDAS, L.J., Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hox-a1 expression and differentiation upon retinoic acid treatment. Proc. nat. Acad. Sci.(Wash.), 90, 9601-9605 (1993).
2. CARROLL, A.G., VOELLER, H.J, SUGARS, L. and GELMANN, P., p53 oncogene mutations in three human prostate cancer cell lines. Prostate, 23, 123-134 (1993).
3. DAWSON, M.I., HOBBS, P.D., STEIN, R.B., BERGER, T.S. and HEYMAN, R.A., In: M.A. Livrea and L. Packer (eds.) Retinoids: new trends in research and clinical applications, pp. 205-221, M. Dekker, New York (1992).
4. DELESCLUSE, C., CAVEY, M.T., MARTIN, B., BERNARD, B.A., REICHERT, U., MAIGNAN, J., DARMON, M. and SHROOT, B., Selective high affinity retinoic acid receptor alpha or beta-gamma ligands. Mol. Pharmacol., 40, 556-562 (1991).
5. FANJUL, A.N., DELIA, D., PIEROTTI, M.A., RIDEOUT, D., QIU, J. and PFAHL, M., 4-Hydroxyphenyl retinamide is a highly selective activator of retinoid receptors. J. biol. Chem. 271, 22441-22446 (1996).
6. FANJUL, A., HOBBS, P.D., JONG, L., CAMERON, J.F., HARLEV, E., GRAUPNER, G., LU, X.-P., DAWSON, M.I. and PFAHL, M., A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature (Lond.), 372, 107-111 (1994).
7. GRAUPNER, G., MALLE, G., MAIGNAN, J., LANG, G., PRUNIERAS, M. and PFAHL, M., 6′-Substituted naphthalene-2-carboxylic acid analogs, a new class of retinoic acid receptor subtype-specific ligands. Biochem. biophys. Res. Comm., 179, 1554-1561 (1991).
8. GRIGNANI, F. and 14 OTHERS, Fusion proteins of the retinoic acid receptorα recruit histone deacelylase in promyelocytic leukaemia. Nature (Lond.), 391, 815-818 (1998).
9. HANKS, G.E., MEYERS, C.E. and SCARDINO, P.T., Cancer. In: V.T. DeVita, Jr., S. Hellman and S.A. Rosenberg (eds.), Principles and practice of oncology (4th ed.), Vol. 1, pp. 1073-1113, Lippincott, Philadelphia (1993).
10. LA VISTA-PICARD, N., HOBBS, P.D., PFAHL, M., DAWSON, M.I. and PFAHL, M., The receptor-DNA complex determines the retinoid response: a mechanism for the diversification of the ligand signal. Mol. cell. Biol., 16, 4137-4146 (1996).
11. LEE, M.-O., DAWSON, M., PICARD, N., HOBBS, P. and PFAHL, M., A novel class of retinoid antagonists and their mechanism of action. J. biol. Chem., 271, 11897-11903 (1996).
12. LEE, M.-O., HOBBS, P.D., ZHANG, X.-K., DAWSON, M.I. and PFAHL, M., A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter. Proc. nat. Acad. Sci. (Wash.), 91, 5632-5636 (1994).
13. LEHMANN, J.M., DAWSON, M.I., HOBBS, P.D., HUSMANN, M. and PFAHL, M., Identification of retinoids with nuclear receptor subtype-selective activities. Cancer Res., 51, 4804-4809 (1991).
14. LEHMANN, J.M., JONG, L., FANJUL, A., CAMERON, J.F., LU, X.-P., HAEFNER, P., DAWSON, M.I. and PFAHL, M., Retinoids selective for retinoid X receptor response pathways. Science, 258, 1944-1946 (1992).
15. LIANG, P. and PARDEE, A.B., Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science, 257, 967-971 (1992).
16. LIN, R., NAGY, L., INOUE, S., SHAO, W., MILLER, W.H. and EVANS, R.M., Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature (Lond.), 391, 811-814 (1998).
17. LOHNES, D., KASTNER, P., DIERICH, A., MARK, M., LEMEUR, M. and CHAMBON, P., Function of retinoic acid receptor gamma in the mouse. Cell, 73, 643-658 (1993)
18. LU, X.-P., FANJUL, A., PICARD, N., PFAHL, M., RUNGTA, D., NARED-HOOD, K., CARTER, B., PIEDRAFITA, F.J., TANG, S., FABBRIZIO, E. and PFAHL, M., Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo. Nature (Med.), 3, 686-690 (1997).
19. MUKHERJEE, R., DAVIES, P.J.A., CROMBIE, D.L., BISCHOFF, E.D., CESARIO, R.M., JOW, L., HAMANN, L.G., BOEHM, M.F., MANDON, C.E., NADZAN, A.M., PATERNITI, J.R., JR. and HEYMAN, R.A., Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature (Lond.), 386, 407-410 (1997).
20. NAGPAL, S., SAUNDERS, M., KASTNER, P., DURAND, B., NAKSHATRI, H. and CHAMBON, P., Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors. Cell, 70, 1007-1019 (1992).
21. PFAHL, M., Vertebrate receptors: molecular biology, dimerization and response elements. In: G. Richards (ed.), Seminars in cell biology, Vol. 5, pp. 202-211, Academic Press, London (1994).
22. PIEDRAFITA, F.J. and PFAHL, M., Retinoid induced apoptosis and SP-1 cleavage occur independently of transcription and required caspase activation. Mol. cell. Biol., 17, 6384-6358 (1997).
23. PIENTA, K.J., NGUYET, N.M. and LEHR, J.E., Treatment of prostate cancer in the rat with the synthetic retinoid fenretinide. Cancer Res., 53, 393-403 (1993).
24. POLLARD, M., LUCKERT, P.H. and SPORN, M.B., Prevention of primary prostate cancer in Lobund-Wistar rats by N-(4-hydroxyphenyl)retinamide. Cancer Res., 51, 3610-3611 (1991).
25. REICHERT, U. and 12 OTHERS, In: B.A. Bernard and B. Shroot (eds.), Pharmacology and the skin: from molecular biology to therapeutics, pp. 117-127, Karger, Basel (1993).
26. SCHADENDORF, D. and 13 OTHERS, Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenogrofts in vivo. J. Cell Biol., 135, 1889-1898 (1996).
27. 1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene, 11, 493-504 (1995).
28. SMITH, M.A., PARKINSON, D.R., CHESON, B.D. and FRIEDMAN, M.A., Retinoids in cancer therapy. J. clin .Oncol., 10, 839-864 (1992).
29. STRICKLAND, S. and MAHDAVI, V., The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell, 15, 393-403 (1978).
30. WILLS, K.N., ZHANG, X.-K. and PFAHL, M., Coordinate expression of functionally distinct thyroid hormone receptor alpha isoforms during neonatal brain development. Mol. Endocrinol., 5, 1109-1119 (1991).
31. YAROVOI, S.V., LU, X.P., PICARD, N., RUNGTA, D., RIDEOUT, D. and PFAHL, M., Selective activation of an apoptotic retinoid precursor in macrophage cell lines. J. biol. Chem., 273 (1998). (In press).
32. ZHANG, X.-K., LIU, Y. and PFAHL, M., A specific defect in the retinoic acid response associated with human lung cancer cell lines. Cancer Res., 54, 5663-5669 (1994).