An efficient one-pot synthesis of (+)-deoxypyridinoline

Tetrahedron Letters

Volumn 40, Issue 51, 1999, Pages 8993-8994

  Adamczyk, Maciej ^a   Johnson, Donald D ^a   Reddy, Rajarathnam E ^a  

^a Department of Chemistry (9NM)   (United States)

Author keywords

Bone collagen; Deoxypyridinoline; Osteoporosis; Pyridinium compounds

Indexed keywords

COLLAGEN; DEOXYPYRIDINOLINE; PYRIDINIUM DERIVATIVE;

ARTICLE; BONE; DRUG SYNTHESIS;

EID: 0033579605     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01936-X     Document Type: Article

References (18)

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11. (b) Adamczyk, M.; Johnson, D. D.; Reddy, R. E. Tetrahedron 1999, 55, 63.
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13. 6, see: Adamczyk, M.; Akireddy, S. R.; Reddy, R. E. Tetrahedron: Asymmetry 1999, 10, 3107.
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15. 2, ether, 0-23°C, 3 h, then 48% HBr, ether, -20°C, 30 min, 54% yield).
16. Adamczyk, M.; Johnson, D. D.; Reddy, R. E. Tetrahedron: Asymmetry 1999, 10, 775.
17. Structure of the reaction intermediates, 4, 5, 6 and see also Ref. 4b. (equation presented)
18. t: 4.64 min, 99.7%, and the spectral properties were consistent with the reported data (Refs. 4b and 5).