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Sulfenic acids (R-S-OH) are chemically unstable and are not known as free acids, but are known mostly from their derivatives, e.g. sulfenyl halides (R-S-Cl). Nevertheless, biological sulfenic acids are known, and in particular a cysteine sulfenic acid is the redox center in streptococcal NADH peroxidase (Stehle, T.; Ahmed, S. A.; Claiborne, A.; Schultz, G. E. J. Mol. Biol. 1991, 221, 1325-1344). The possibility of derivitization of a cofactor dithiolene might provide an expanation for the observations of Bastian et al. (Bastian, N. R.; Foster, M. J. P.; Pope, J. C. Biofactors 1995, 5, 5-10) of modified Mo(V) EPR and optical spectra in the presence of NO and related compounds.
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(1995)
Biofactors
, vol.5
, pp. 5-10
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Bastian, N.R.1
Foster, M.J.P.2
Pope, J.C.3
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77
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0002236433
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2-phenylsulfinyl ligands has been reported (Vasyutinskaya, E. A.; Eremenko, I. L.; Pasynskii, A. A.; Yanovskii, A. I.; Struchkov, Yu. T. Zh. Neorg. Khim. 1991, 36, 1707-1709).
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(1991)
Zh. Neorg. Khim.
, vol.36
, pp. 1707-1709
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Vasyutinskaya, E.A.1
Eremenko, I.L.2
Pasynskii, A.A.3
Yanovskii, A.I.4
Struchkov, Yu.T.5
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79
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0029159268
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Schultz, B. E.; Hille, R.; Holm, R. H. J. Am. Chem. Soc. 1995, 117, 827-828.
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(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 827-828
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Schultz, B.E.1
Hille, R.2
Holm, R.H.3
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81
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84920311076
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note
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We note that there is a clear difference between chemically unusual or novel and chemically unreasonable; the active sites of very many metalloproteins can be considered to be chemically unusual.
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