Design, synthesis, and biological evaluation of spider toxin (argiotoxin-636) analogs as NMDA receptor antagonists

Pharmaceutical Research

Volumn 15, Issue 1, 1998, Pages 31-38

  Moe, Scott T ^a   Smith, Daryl L ^a   Chien, Yongwei ^a   Raszkiewicz, Joanna L ^a   Artman, Linda D ^a   Mueller, Alan L ^a  

^a NPS Pharmaceutical Inc   (United States)

Author keywords

Araxin(TM) compounds; Arg 636; Argiotoxin 636; Glutamate; Ischemic stroke; N methyl D aspartate; NMDA; Polyamine spider toxins

Indexed keywords

ARGIOTOXIN 636; ARGIOTOXIN 636 DERIVATIVE; CALCIUM; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; POLYAMINE DERIVATIVE; SPIDER VENOM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CAPILLARY GAS CHROMATOGRAPHY; CARDIOVASCULAR EFFECT; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; GRANULE CELL; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MASS SPECTROMETRY; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLOOD PRESSURE; DRUG DESIGN; HEART RATE; MALE; PHENYLACETATES; POLYAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPIDER VENOMS; SPIDERS;

EID: 0031935687     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011988317683     Document Type: Article

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