Inhibition of Phosphatase Activity by Positively-charged Cyclodextrins

Organic Letters

Volumn 1, Issue 12, 1999, Pages 1945-1948

  Ghosh, Mousumi ^a   Sanders, Tanya C ^a   Zhang, Rui ^a   Seto, Christopher T ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; CYCLODEXTRIN; ENZYME INHIBITOR; NITROPHENOL; NITROPHENYL PHOSPHATE; ORGANOPHOSPHORUS COMPOUND; PHOSPHATASE; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE LAMBDA; PROTEIN-TYROSINE-PHOSPHATASE LAMBDA;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; KINETICS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ACID PHOSPHATASE; CYCLODEXTRINS; ENZYME INHIBITORS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; NITROPHENOLS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHOTYROSINE; PROTEIN-TYROSINE-PHOSPHATASE;

EID: 0033576440     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol990301h     Document Type: Article

References (23)

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11. For a demonstration that aminocyclodextrins can inhibit neurite growth by binding to glycosaminoglycan sulfates, see: Borrajo, A. M. P.; Gorin, B. I.; Dostaler, S. M.; Riopelle, R. J.; Thatcher, G. R. J. Bioorg. Med. Chem. Lett. 1997, 7, 1185.
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15. Addition of unmodified α- or β-cyclodextrin to the enzyme-catalyzed reactions has no effect on the reaction rate.
16. -1. See ref 3b.
17. -1.
18. Schneider, H.-J.; Hacket, F.; Rudiger, V.; Ikeda, H. Chem. Rev. 1998, 98, 1755.
19. The assignments of the resonances in the NMR spectra were performed using COSY spectra of the aryl phosphate - cyclodextrin complexes.
20. Sandstrom, J. Dynamic NMR Spectroscopy; Academic Press: New York, 1982.
21. -2) that is fully bound to cyclodextrin 1β, along with the fact that this acquisition which was recorded at room temperature is well below the coalescence point. See also ref 17.
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23. Reference 5 provides some related coalescence temperature data for similar aminocyclodextrin - aryl phosphate complexes.