Derivatized cyclodextrins as peptidomimetics: Influence on neurite growth

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 9, 1997, Pages 1185-1190

  Borrajo, Alison M P ^a   Gorin, Boris I ^a   Dostaler, Suzanne M ^a   Riopelle, Richard J ^a   Thatcher, Gregory R J ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLODEXTRIN DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BIOASSAY; CHICKEN; COLORIMETRY; CONTROLLED STUDY; DRUG SYNTHESIS; IN VITRO STUDY; NERVE CELL; NERVE FIBER GROWTH; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

EID: 0030984729     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00180-7     Document Type: Article

References (24)

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6. 2 for 4 days Excess amines were removed under vacuum and the residue obtained, dissolved in deionized water (10 mL) and stirred with Cl form anion exchange resin The resin was removed by filtration and the filtrate concentrated under vacuum to yield an oil which was dialysed against three changes of 2 L of Tris-HCl (1 mM, pH 8.6) using Spectra-Por CE resin (cut-off MW = 500) The tubing contents were concentrated under vacuum to give a viscous brown oil (yield 24 mg).
7. 2 for 4 days Excess amines were removed under vacuum and the residue obtained, dissolved in deionized water (10 mL) and stirred with Cl form anion exchange resin The resin was removed by filtration and the filtrate concentrated under vacuum to yield an oil which was dialysed against three changes of 2 L of Tris-HCl (1 mM, pH 8.6) using Spectra-Por CE resin (cut-off MW = 500) The tubing contents were concentrated under vacuum to give a viscous brown oil (yield 24 mg).
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21. Heterogeneous CD sulfates have been examined as therapeutics, for example in treatment of angiogenesis [Folkman, J.; Weisz, P. B.; Joullie, M. M.; Li, W. W.; Ewing, W. R. Science 1989, 243, 1490; Sakairi, N.; Kuzuhara, H.; Okamoto, T.; Yajima, M.; Bioorg. Med. Chem. 1996, 4, 2187] and AIDS therapy [Moriya, T.; Kurita, H., Matsumoto, K.; Otake, T.; Mori, H., Morimoto, M.; Ueba, N.; Kunita, N. J. Med. Chem. 1991, 34, 2301]. One PACD has been examined recently in molecular recognition of nucleotides [Eliseev, A V.; Schneider, H. J .J. Am. Chem. Soc. 1994, 116, 6081]. Important in this last work as in most postulated therapeutic applications of CDs is encapsulation or binding within the hydrophobic cavity.
22. Heterogeneous CD sulfates have been examined as therapeutics, for example in treatment of angiogenesis [Folkman, J.; Weisz, P. B.; Joullie, M. M.; Li, W. W.; Ewing, W. R. Science 1989, 243, 1490; Sakairi, N.; Kuzuhara, H.; Okamoto, T.; Yajima, M.; Bioorg. Med. Chem. 1996, 4, 2187] and AIDS therapy [Moriya, T.; Kurita, H., Matsumoto, K.; Otake, T.; Mori, H., Morimoto, M.; Ueba, N.; Kunita, N. J. Med. Chem. 1991, 34, 2301]. One PACD has been examined recently in molecular recognition of nucleotides [Eliseev, A V.; Schneider, H. J .J. Am. Chem. Soc. 1994, 116, 6081]. Important in this last work as in most postulated therapeutic applications of CDs is encapsulation or binding within the hydrophobic cavity.
23. Heterogeneous CD sulfates have been examined as therapeutics, for example in treatment of angiogenesis [Folkman, J.; Weisz, P. B.; Joullie, M. M.; Li, W. W.; Ewing, W. R. Science 1989, 243, 1490; Sakairi, N.; Kuzuhara, H.; Okamoto, T.; Yajima, M.; Bioorg. Med. Chem. 1996, 4, 2187] and AIDS therapy [Moriya, T.; Kurita, H., Matsumoto, K.; Otake, T.; Mori, H., Morimoto, M.; Ueba, N.; Kunita, N. J. Med. Chem. 1991, 34, 2301]. One PACD has been examined recently in molecular recognition of nucleotides [Eliseev, A V.; Schneider, H. J .J. Am. Chem. Soc. 1994, 116, 6081]. Important in this last work as in most postulated therapeutic applications of CDs is encapsulation or binding within the hydrophobic cavity.
24. Heterogeneous CD sulfates have been examined as therapeutics, for example in treatment of angiogenesis [Folkman, J.; Weisz, P. B.; Joullie, M. M.; Li, W. W.; Ewing, W. R. Science 1989, 243, 1490; Sakairi, N.; Kuzuhara, H.; Okamoto, T.; Yajima, M.; Bioorg. Med. Chem. 1996, 4, 2187] and AIDS therapy [Moriya, T.; Kurita, H., Matsumoto, K.; Otake, T.; Mori, H., Morimoto, M.; Ueba, N.; Kunita, N. J. Med. Chem. 1991, 34, 2301]. One PACD has been examined recently in molecular recognition of nucleotides [Eliseev, A V.; Schneider, H. J .J. Am. Chem. Soc. 1994, 116, 6081]. Important in this last work as in most postulated therapeutic applications of CDs is encapsulation or binding within the hydrophobic cavity.