Detection of scrapie agent in the peripheral nervous system of a diseased sheep

Neurobiology of Disease

Volumn 3, Issue 3, 1996, Pages 191-195

  Groschup, Martin H ^a   Weiland, Frank ^a   Straub, Otto Christian ^a   Pfaff, Eberhard ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INOCULATION; MOUSE; MUSCLE; NERVE TRACT; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRION; PRIORITY JOURNAL; SCRAPIE AGENT; SHEEP DISEASE; TISSUE HOMOGENATE; VIRUS DETECTION; VIRUS INFECTIVITY; VIRUS TITRATION;

EID: 0030174980     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.1996.0019     Document Type: Article

References (20)

1. Belt, P. B. G. M., Muilemann, I. H., Schreuder, B. E. C., Ruijter, J. B., Gielkens, A. L. J., & Smits, M. A. (1995) Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie. J. Gen. Virol. 76, 509-517.
2. Bruce, M. E., & Dickinson, A. G. (1979) Biological stability of different classes of scrapie agent. In: Slow Transmissible Diseases of the Nervous System (S. B. Prusiner and W. Hadlow, Eds.), pp. 71-86. Academic Press, New York.
3. Bruce, M. E., & Dickinson, A. G. (1987) Biological evidence that scrapie agent has an independant genome. J. Gen. Virol. 68, 79-89.
4. Clark, A. M., & Moar, J. A. E. (1992) Scrapie: A clinical assessment. Vet. Rec. 130, 377-378.
5. Detwiler, L. A. (1992) Scrapie. Rev. Sci. Tech./Off. Int. Epizoot. 11, 491-537.
6. Foster, J. D., McKelvey, W. A., Mylne, M. J., Williams, A., Hunter, N., Hope, J., & Fraser, H. (1992) Studies on maternal transmission of scrapie in sheep by embryo transfer. Vet. Rec. 130, 341-343.
7. Foster, J. D., Bruce, M., McConnell, I., Chree, A., & Fraser, H. (1996) Detection of BSE infectivity in brain and spleen of experimentally infected sheep. Vet. Rec. 138, 546-555.
8. Fraser, H., & Foster, J. D. (1994) Transmission of mice, sheep and goats and bioassay of bovine tissues. In: Transmissible Spongiform Encephalopathies - A Consultation on BSE with the Scientific Veterinary Committee of the Commission of the European Communities, Brussels, September 14-15, 1994, pp. 145-159.
9. Fraser, H., Bruce, M. E., Chree, A., McConnell, I., & Wells, G. A. H. (1992) Transmission of bovine spongiform encephalopathy and scrapie to mice. J. Gen. Virol. 73, 1891-1997.
10. Groschup, M. H., Langeveld, J., & Pfaff, E. (1994) The major species specific epitope of prion protein of ruminants. Arch. Virol. 136, 423-431.
11. Hadlow, J. W., Race, R. E., Kennedy, R. C., & Eklund, C. M. (1979) Natural infection of the sheep with scrapie virus. In: Slow Transmissible Diseases of the Nervous System (S. B. Prusiner and W. J. Hadlow, Eds.), Vol. 2, pp. 331-356. Academic Press, New York.
12. Hadlow, W. J., Kennedy, R. C., Race, R. E., & Eklund, C. M. (1980) Virologic and neurohistologic findings in dairy goats affected with natural scrapie. Vet. Pathol. 17, 187-199.
13. Hadlow, W. J., Kennedy, R. C., & Race, R. E. (1982) Natural infection of Suffolk sheep with scrapie virus. Infect. Dis. 146, 657-664.
14. Kimberlin, R. H. (1976) Experimental scrapie in the mouse: A review of an important model disease. Sci. Prog. 6, 461-481.
15. Kimberlin, R. H., & Walker, C. A. (1980) Pathogenesis of mouse scrapie: Evidence for neural spread of infection to the CNS. J. Gen. Virol. 51, 183-187.
16. Kimberlin, R. H., Field, H. J., & Walker, C. A. (1983) Pathogenesis of mouse scrapie: Evidence for spread of infection from central to peripheral nervous system. J. Gen. Virol. 64, 713-716.
17. Pattison, I. H., Hoare, M. N., & Jebbett, J. N. (1972) Spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie-affected sheep. Vet. Rec. 9, 465-468.
18. Prusiner, S. B. (1982) Novel proteinaceous infectious particles cause scrapie. Science 216, 136-144.
19. Wilesmith, J. W., Ryan, J. B. M., & Atkinson, M. J. (1991) Bovine spongiform encephalopathy: Epidemiological studies on the origin. Vet. Rec. 128, 199-203.
20. Will, R. G., Ironside, J. W., Zeidler, M., Cousens, S. N., Estibeiro, K., Alperovitch, A., Poser, S., Pocchiari, M., Hofman, A., & Smith, P. G. (1996) A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 34, 921-925.